Cited by 246Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressImmune Response and Inflammation

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NRROS negatively regulates reactive oxygen species during host defence and autoimmunity

Noubade, Rajkumar, Wong, Kit, Ota, Naruhisa, Rutz, Sascha, Eidenschenk, Celine, Valdez, Patricia A., Ding, Jiabing, Peng, Ivan, Sebrell, Andrew, Caplazi, Patrick, DeVoss, Jason, Soriano, Robert H., Sai, Tao, Lu, Rongze, Modrusan, Zora, Hackney, Jason, Ouyang, Wenjun·2014·Nature

DOI 10.1038/nature13152

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Abstract

Reactive oxygen species (ROS) produced by phagocytes are essential for host defence against bacterial and fungal infections. Individuals with defective ROS production machinery develop chronic granulomatous disease. Conversely, excessive ROS can cause collateral tissue damage during inflammatory processes and therefore needs to be tightly regulated. Here we describe a protein, we termed negative regulator of ROS (NRROS), which limits ROS generation by phagocytes during inflammatory responses. NRROS expression in phagocytes can be repressed by inflammatory signals. NRROS-deficient phagocytes produce increased ROS upon inflammatory challenges, and mice lacking NRROS in their phagocytes show enhanced bactericidal activity against Escherichia coli and Listeria monocytogenes. Conversely, these mice develop severe experimental autoimmune encephalomyelitis owing to oxidative tissue damage in the central nervous system. Mechanistically, NRROS is localized to the endoplasmic reticulum, where it directly interacts with nascent NOX2 (also known as gp91(phox) and encoded by Cybb) monomer, one of the membrane-bound subunits of the NADPH oxidase complex, and facilitates the degradation of NOX2 through the endoplasmic-reticulum-associated degradation pathway. Thus, NRROS provides a hitherto undefined mechanism for regulating ROS production--one that enables phagocytes to produce higher amounts of ROS, if required to control invading pathogens, while minimizing unwanted collateral tissue damage.

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Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
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Self-citation
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West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659
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Pollock, J. D., Williams, D. A., Gifford, M. A. C., Li, L. L., Du, X., Fisherman, J., Orkin, S. H., Doerschuk, C. M., & Dinauer, M. C. (1995) · Nature Genetics · doi:10.1038/ng0295-202 · Cited by 921
Independent filtering increases detection power for high-throughput experiments
Bourgon, R., Gentleman, R. C., & Huber, W. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914005107 · Cited by 731

Show all 39 references

Research works printed but not linked: 2

DeLeo, F. R. et al. Processing and maturation of flavocytochrome b558 include incorporation of heme as a prerequisite for heterodimer assembly. J. Biol. Chem. 275, 13986–13993 (2000) · DOI
Nikić, I. et al. A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. Nature Med. 17, 495–499 (2011) · DOI · Paper page

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Kong, C., Li, D., Hu, Y., Gao, P., Zhang, Y., Zhou, L., Ge, X., Guo, X., Han, J., & Yang, H. (2023) · Journal of Virology · doi:10.1128/jvi.01689-22 · Cited by 47
Ablation of serum response factor in hepatic stellate cells attenuates liver fibrosis
Kong, M., Hong, W., Shao, Y., Lv, F., Fan, Z., Li, P., Xu, Y., & Guo, J. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01831-8 · Cited by 47
Beyond bacterial killing: NADPH oxidase 2 is an immunomodulator
Trevelin, S. C., Shah, A. M., & Lombardi, G. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.02.009 · Cited by 49
Epigenetic activation of PERP transcription by MKL1 contributes to ROS-induced apoptosis in skeletal muscle cells
Li, Z., Chen, B., Dong, W., Xu, W., Song, M., Fang, M., Guo, J., & Xu, Y. (2018) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2018.07.011 · Cited by 46
Progress of stimulus responsive nanosystems for targeting treatment of bacterial infectious diseases
Yang, N., Sun, M., Wang, H., Hu, D., Zhang, A., Khan, S., Chen, Z., Chen, D., & Xie, S. (2024) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2024.103078 · Cited by 47
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Zhao, L.-L., Luo, J.-J., Cui, J., Li, X., Hu, R.-N., Xie, X.-Y., Zhang, Y., Ding, W., Ning, L., Luo, J., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c19019 · Cited by 47
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Zong, C., Zhang, H., Yang, X. F., Gao, L., Hou, J., Ye, F., Jiang, J., Yang, Y., Li, R., Han, Z., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0366-7 · Cited by 45
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Barth, E., Srivastava, A., Stojiljkovic, M. R., Frahm, C., Axer, H., Witte, O. W., & Marz, M. (2019) · Aging · doi:10.18632/aging.102345 · Cited by 47
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Byun, D. J., Lee, J., Ko, K., & Hyun, Y. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01447-z · Cited by 47
TRAF4 promotes lung cancer aggressiveness by modulating tumor microenvironment in normal fibroblasts
Kim, E., Kim, W., Lee, S., Chun, J., Kang, J., Park, G., Han, I., Yang, H. J., Youn, H., & Youn, B. (2017) · Scientific Reports · doi:10.1038/s41598-017-09447-z · Cited by 42
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Numaga‐Tomita, T., Oda, S., Shimauchi, T., Nishimura, A., Mangmool, S., & Nishida, M. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00056 · Cited by 42
How the phagocyte NADPH oxidase regulates innate immunity
Thomas, D. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.06.011 · Cited by 43
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Rolas, L., Boussif, A., Weiss, E., Lettéron, P., Haddad, O., Benna, J. E., Rautou, P., Moreau, R., & Périanin, A. (2017) · Gut · doi:10.1136/gutjnl-2016-313443 · Cited by 41
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Chen, J., Fang, G., Pang, L., Sheng, Y., Zhang, Q., Zhou, Y., Zhou, S., Lu, Y., Liu, Z., Zhang, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25727-9 · Cited by 41
Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats via sympathetic activation
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Liu, X., Zhang, J., Zeigler, A. C., Nelson, A. R., Lindsey, M. L., & Saucerman, J. J. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.1901444 · Cited by 38
LynA regulates an inflammation-sensitive signaling checkpoint in macrophages
Freedman, T. S., Tan, Y. X., Skrzypczynska, K. M., Manz, B. N., Sjaastad, F. V., Goodridge, H. S., Lowell, C. A., & Weiss, A. (2015) · eLife · doi:10.7554/elife.09183 · Cited by 36
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Gonzalez, A. L., Dungan, M. M., Smart, C. D., Madhur, M. S., & Doran, A. C. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0284 · Cited by 42
Autophagy proteins are not universally required for phagosome maturation
Cemma, M., Grinstein, S., & Brumell, J. H. (2016) · Autophagy · doi:10.1080/15548627.2016.1191724 · Cited by 40
Platelet granule release is associated with reactive oxygen species generation during platelet storage: A direct link between platelet pro-inflammatory and oxidation states
Ghasemzadeh, M., & Hosseini, E. (2017) · Thrombosis Research · doi:10.1016/j.thromres.2017.06.016 · Cited by 39
Structure-dependent antiviral activity of catechol derivatives in pyroligneous acid against the encephalomycarditis virus
Li, R., Narita, R., Ouda, R., Kimura, C., Nishimura, H., Yatagai, M., Fujita, T., & Watanabe, T. (2018) · RSC Advances · doi:10.1039/c8ra07096b · Cited by 38
Downregulation of vimentin in macrophages infected with live Mycobacterium tuberculosis is mediated by Reactive Oxygen Species
Mahesh, P., Retnakumar, R. J., & Mundayoor, S. (2016) · Scientific Reports · doi:10.1038/srep21526 · Cited by 39
Protein disulfide isomerase and Nox: new partners in redox signaling
Trevelin, S. C., & Lopes, L. R. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666151029112523 · Cited by 37
Effects of ORAI calcium release-activated calcium modulator 1 (ORAI1) on neutrophil activity in dairy cows with subclinical hypocalcemia1
Zhang, B., Guo, H., Yang, W., Li, M., Zou, Y., Loor, J. J., Xia, C., & Xu, C. (2019) · Journal of Animal Science · doi:10.1093/jas/skz209 · Cited by 37
Porphyrin-based covalent organic framework with self-accelerated M−N4 bimetallic active sites for enhanced electrochemical detection of trace hydrogen peroxide
Bai, Y., Gao, W., Wang, Q., Yu, B., Wei, J., Gao, C., Zhu, P., & Yu, J. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.134435 · Cited by 37
Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst
Graham, D. B., Becker, C., Doan, A., Goel, G., Villablanca, E. J., Knights, D., Mok, A., Ng, A., Doench, J. G., Root, D. E., et al. (2015) · Nature Communications · doi:10.1038/ncomms8838 · Cited by 36
The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer
Zhou, Y., Huang, R., Wei, X., Yu, W., Min, Z., & Ye, M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01265 · Cited by 37
CuS@CDs nanozymes with photothermal-enhanced peroxidase-like activities for colorimetric/fluorescent detection of glutathione and ferric ions in the coexisting system
Wang, H., Zhao, L., Gao, Z., Cui, A., Mu, X., Wang, X., Shan, G., & Chen, Y. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.134726 · Cited by 35
PGC-1α limits angiotensin II-induced rat vascular smooth muscle cells proliferation via attenuating NOX1-mediated generation of reactive oxygen species
Zhao, Q., Zhang, J., & Wang, H. (2015) · Bioscience Reports · doi:10.1042/bsr20150112 · Cited by 35

Authors: Noubade, R., Wong, K., Ota, N., Rutz, S., Eidenschenk, C., Valdez, P. A., Ding, J., Peng, I., Sebrell, A., Caplazi, P., DeVoss, J., Soriano, R. H., Sai, T., Lu, R., Modrusan, Z., Hackney, J., & Ouyang, W.
Affiliations: Genentech (US)
Corresponding author: Ouyang, Wenjun
ORCID: Noubade, Rajkumar
Ota, Naruhisa
Rutz, Sascha
Valdez, Patricia A.
Caplazi, Patrick
DeVoss, Jason
Sai, Tao
Lu, Rongze
Modrusan, Zora
Hackney, Jason
Ouyang, Wenjun
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2014-04-13
Volume: 509
Issue: 7499
Pages: 235-239
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature13152
OpenAlex: W2090106964
Cited by: 246
References: 39
Citations by year: 2026: 13 · 2025: 21 · 2024: 20 · 2023: 22 · 2022: 18 · 2021: 18 · 2020: 24 · 2019: 22 · 2018: 20 · 2017: 21 · 2016: 25 · 2015: 15 · 2014: 7
FWCI: 10.35
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: reactive oxygen species, NADPH oxidase, NOX2, gp91phox, endoplasmic reticulum, ER-associated degradation, phagocytes, host defense, autoimmunity, experimental autoimmune encephalomyelitis, Escherichia coli, Listeria monocytogenes, collateral tissue damage, inflammation, leucine-rich repeat proteins
MeSH terms: Animals, Bone Marrow Cells, Central Nervous System, Encephalomyelitis, Autoimmune, Experimental, Endoplasmic Reticulum, Escherichia coli, Female, Inflammation, Listeria monocytogenes, Macrophages, Male, Membrane Proteins, Oxidation-Reduction, Phagocytes, Proteins, Autoimmunity, Reactive Oxygen Species, Oxidative Stress, NADPH Oxidases, Mice, Latent TGF-beta Binding Proteins

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NRROS negatively regulates reactive oxygen species during host defence and autoimmunity

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