NOX enzymes and the biology of reactive oxygen

Superoxide Dismutase

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Cell transformation by the superoxide-generating oxidase Mox1

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Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

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Killing activity of neutrophils is mediated through activation of proteases by K+ flux

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Reversible Inactivation of the Tumor Suppressor PTEN by H2O2

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Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

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Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

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Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

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The Neutrophil NADPH Oxidase

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Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis

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Identification of Renox, an NAD(P)H oxidase in kidney

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Novel gp91 ^<i>phox</i> Homologues in Vascular Smooth Muscle Cells: nox1 Mediates Angiotensin II–Induced Superoxide Formation and Redox-Sensitive Signaling Pathways

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Homologs of gp91 phox : cloning and tissue expression of Nox3, Nox4, and Nox5

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The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

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Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

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Cloning of Two Human Thyroid cDNAs Encoding New Members of the NADPH Oxidase Family

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A Ca2+-activated NADPH Oxidase in Testis, Spleen, and Lymph Nodes

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The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

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Distinct Subcellular Localizations of Nox1 and Nox4 in Vascular Smooth Muscle Cells

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A Novel Superoxide-producing NAD(P)H Oxidase in Kidney

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The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H2O2 and Plays an Integral Role in Insulin Signal Transduction

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Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense

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Two Novel Proteins Activate Superoxide Generation by the NADPH Oxidase NOX1

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Reactive oxygen generated by Nox1 triggers the angiogenic switch

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Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1

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Inactivating Mutations in the Gene for Thyroid Oxidase 2 (THOX2) and Congenital Hypothyroidism

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Purification of a Novel Flavoprotein Involved in the Thyroid NADPH Oxidase

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Upregulation of Nox-Based NAD(P)H Oxidases in Restenosis After Carotid Injury

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Molecular Basis of Phosphorylation-Induced Activation of the NADPH Oxidase

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Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH Oxidases

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Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91<i>phox</i>

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Novel homologs of gp91phox

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Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation

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Pulsatile Versus Oscillatory Shear Stress Regulates NADPH Oxidase Subunit Expression

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X-ray crystal structure of canine myeloperoxidase at 3 Å resolution

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Structure of the TPR Domain of p67phox in Complex with Rac·GTP

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Proteins Homologous to p47 and p67 Support Superoxide Production by NAD(P)H Oxidase 1 in Colon Epithelial Cells

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Lifespan Extension and Rescue of Spongiform Encephalopathy in Superoxide Dismutase 2 Nullizygous Mice Treated with Superoxide Dismutase–Catalase Mimetics

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Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo

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Singlet oxygen production by biological systems

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NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells

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Tetratricopeptide Repeat (TPR) Motifs of p67 Participate in Interaction with the Small GTPase Rac and Activation of the Phagocyte NADPH Oxidase

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Regulation of the Neutrophil Respiratory Burst Oxidase

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Phosphorylation of p47 phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation

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NOXO1, Regulation of Lipid Binding, Localization, and Activation of Nox1 by the Phox Homology (PX) Domain

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The p67 Activation Domain Regulates Electron Flow from NADPH to Flavin in Flavocytochromeb 558

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NAD(P)H Oxidase 1, a Product of Differentiated Colon Epithelial Cells, Can Partially Replace Glycoprotein 91 phox in the Regulated Production of Superoxide by Phagocytes

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Type IHelicobacter pyloriLipopolysaccharide Stimulates Toll-Like Receptor 4 and Activates Mitogen Oxidase 1 in Gastric Pit Cells

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Modulation of p47 PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase

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An NAD(P)H oxidase regulates growth and transcription in melanoma cells

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Activation of the Leukocyte NADPH Oxidase by Phorbol Ester Requires the Phosphorylation of p47 on Serine 303 or 304

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PU.1, Interferon Regulatory Factor 1, and Interferon Consensus Sequence-binding Protein Cooperate to Increase gp91 Expression

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Lethal Weapons

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Solution structure of the PX domain, a target of the SH3 domain.

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Hypochlorous Acid Generated by Myeloperoxidase Modifies Adjacent Tryptophan and Glycine Residues in the Catalytic Domain of Matrix Metalloproteinase-7 (Matrilysin)

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A Novel Assay System Implicates PtdIns(3,4)P2, PtdIns(3)P, and PKCδ in Intracellular Production of Reactive Oxygen Species by the NADPH Oxidase

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The NADPH oxidase and chronic granulomatous disease

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Association of gp91phox homolog Nox1 with anchorage-independent growth and MAP kinase-activation of transformed human keratinocytes

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NADPH Oxidase Is Involved in Prostaglandin F2α-induced Hypertrophy of Vascular Smooth Muscle Cells

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Guinea pig gastric mucosal cells produce abundant superoxide anion through an NADPH oxidase-like system

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Superoxide production and expression of NAD(P)H oxidases by transformed and primary human colonic epithelial cells

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Role of NADPH Oxidases in the Control of Vascular Gene Expression

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Regulation of growth and apoptosis of cultured guinea pig gastric mucosal cells by mitogenic oxidase 1

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Catalytic Antibody Bridges Innate and Adaptive Immunity

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The p47phox PX Domain

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The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

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ROS function in redox signaling and oxidative stress

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Reactive Oxygen Species in Inflammation and Tissue Injury

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Mitochondria, Oxidants, and Aging

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Crosstalk of reactive oxygen species and NF-κB signaling

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Neutrophils and immunity: challenges and opportunities

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Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy

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Reconciling the chemistry and biology of reactive oxygen species

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Myeloperoxidase: friend and foe

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H ₂ O ₂ , a Necessary Evil for Cell Signaling

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Ros and ros-mediated cellular signaling

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Chemistry and biology of reactive oxygen species in signaling or stress responses

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Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

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Beyond oxidative stress: an immunologist's guide to reactive oxygen species

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The role of oxidative stress in neurodegenerative diseases

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Air Pollution and Cardiovascular Disease

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Radical-free biology of oxidative stress

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13 reasons why the brain is susceptible to oxidative stress

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ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

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