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Genome sequencing of normal cells reveals developmental lineages and mutational processes
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“With the exception of some initial studies, far less is known about somatic mutation in other species1–7.”
From Somatic mutation rates scale with lifespan across mammals (2022) · cites this paper as [2]
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Cites
Signatures of mutational processes in human cancer
Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660
Self-citationSingle Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204
Self-citationIdentification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Self-citationMutational heterogeneity in cancer and the search for new cancer-associated genes
Lawrence, M. S., Stojanov, P., Polak, P., Kryukov, G. V., Cibulskis, K., Sivachenko, A., Carter, S. L., Stewart, C., Mermel, C. H., Roberts, S. A., et al. (2013) · Nature · doi:10.1038/nature12213 · Cited by 5,461
Sato, T., Stange, D. E., Ferrante, M., Vries, R. G. J., van Es, J. H., van den Brink, S., van Houdt, W. J., Pronk, A., van Gorp, J., Siersema, P. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.050 · Cited by 3,753
The Life History of 21 Breast Cancers
Nik-Zainal, S., Van Loo, P., Wedge, D. C., Alexandrov, L. B., Greenman, C. D., Lau, K. W., Raine, K., Jones, D., Marshall, J., Ramakrishna, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.023 · Cited by 1,443
Self-citationChromatin organization is a major influence on regional mutation rates in human cancer cells
Schuster-Böckler, B., & Lehner, B. (2012) · Nature · doi:10.1038/nature11273 · Cited by 657
Research works printed but not linked: 23
- Shapiro, E., Biezuner, T. & Linnarsson, S. Single-cell sequencing-based technologies will revolutionize whole-organism science. Nature Rev. Genet. 14, 618–630 (2013) · DOI · Paper page
- Sato, T. & Clevers, H. Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science 340, 1190–1194 (2013) · DOI · Paper page
- De, S. Somatic mosaicism in healthy human tissues. Trends Genet. 27, 217–223 (2011) · DOI
- Carlson, C. A. et al. Decoding cell lineage from acquired mutations using arbitrary deep sequencing. Nature Methods 9, 78–80 (2012) · DOI
- Kennedy, S. R., Loeb, L. A. & Herr, A. J. Somatic mutations in aging, cancer and neurodegeneration. Mech. Ageing Dev. 133, 118–126 (2012) · DOI
- Salipante, S. J. & Horwitz, M. S. Phylogenetic fate mapping. Proc. Natl Acad. Sci. USA 103, 5448–5453 (2006) · DOI
- Salipante, S. J. & Horwitz, M. S. A phylogenetic approach to mapping cell fate. Curr. Top. Dev. Biol. 79, 157–184 (2007) · DOI
- Shibata, D. & Tavare, S. Counting divisions in a human somatic cell tree: how, what and why? Cell Cycle 5, 610–614 (2006) · DOI
- Wasserstrom, A. et al. Reconstruction of cell lineage trees in mice. PLoS ONE 3, e1939 (2008) · DOI
- Zhou, W. et al. Use of somatic mutations to quantify random contributions to mouse development. BMC Genomics 14, 39 (2013) · DOI
- Lasken, R. S. Single-cell sequencing in its prime. Nature Biotechnol. 31, 211–212 (2013) · DOI
- Barker, N. et al. Lgr5+ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell 6, 25–36 (2010) · DOI · Paper page
- Snippert, H. J. et al. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell 143, 134–144 (2010) · DOI · Paper page
- Plusa, B. et al. The first cleavage of the mouse zygote predicts the blastocyst axis. Nature 434, 391–395 (2005) · DOI
- Bruce, A. W. & Zernicka-Goetz, M. Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate. Curr. Opin. Genet. Dev. 20, 485–491 (2010) · DOI
- Barker, N. et al. Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells. Cold Spring Harb. Symp. Quant. Biol. 73, 351–356 (2008) · DOI
- Schepers, A. G., Vries, R., van den Born, M., van de Wetering, M. & Clevers, H. Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes. EMBO J. 30, 1104–1109 (2011) · DOI · Paper page
- Alexandrov, L. B., Nik-Zainal, S., Wedge, D. C., Campbell, P. J. & Stratton, M. R. Deciphering signatures of mutational processes operative in human cancer. Cell Rep. 3, 246–259 (2013) · DOI
- van Loon, B., Markkanen, E. & Hubscher, U. Oxygen as a friend and enemy: how to combat the mutational potential of 8-oxo-guanine. DNA Repair (Amst.) 9, 604–616 (2010) · DOI
- Leushacke, M., Ng, A., Galle, J., Loeffler, M. & Barker, N. Lgr5+ gastric stem cells divide symmetrically to effect epithelial homeostasis in the pylorus. Cell Rep. 5, 349–356 (2013) · DOI
- Nik-Zainal, S. et al. Mutational processes molding the genomes of 21 breast cancers. Cell 149, 979–993 (2012) · DOI · Paper page
- Felsenstein, J. PHYLIP—Phylogeny Inference Package (Version 3.2). Cladistics 5, 164–166 (1989)
- Yang, Z. & Rannala, B. Molecular phylogenetics: principles and practice. Nature Rev. Genet. 13, 303–314 (2012) · DOI
Cited by
Sorted by citations
Regev, A., Teichmann, S. A., Lander, E. S., Amit, I., Benoist, C., Birney, E., Bodenmiller, B., Campbell, P., Carninci, P., Clatworthy, M., et al. (2017) · eLife · doi:10.7554/elife.27041 · Cited by 2,232
Self-citationVariation in cancer risk among tissues can be explained by the number of stem cell divisions
Tomasetti, C., & Vogelstein, B. (2015) · Science · doi:10.1126/science.1260825 · Cited by 1,927
Drost, J., & Clevers, H. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0007-6 · Cited by 1,790
Self-citationHigh burden and pervasive positive selection of somatic mutations in normal human skin
Martincorena, I., Roshan, A., Gerstung, M., Ellis, P., Van Loo, P., McLaren, S., Wedge, D. C., Fullam, A., Alexandrov, L. B., Tubio, J. M., et al. (2015) · Science · doi:10.1126/science.aaa6806 · Cited by 1,770
Self-citationThe Technology and Biology of Single-Cell RNA Sequencing
Kolodziejczyk, A. A., Kim, J. K., Svensson, V., Marioni, J. C., & Teichmann, S. A. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.04.005 · Cited by 1,487
Metadata
- Authors
- Behjati, S., Huch, M., van Boxtel, R., Karthaus, W., Wedge, D. C., Tamuri, A. U., Martincorena, I., Petljak, M., Alexandrov, L. B., Gundem, G., Tarpey, P. S., Roerink, S., Blokker, J., Maddison, M., Mudie, L., Robinson, B., Nik-Zainal, S., Campbell, P., Goldman, N., van de Wetering, M., Cuppen, E., Clevers, H., & Stratton, M. R.
- Venue
- Nature
- Published
- 2014-06-29
- Volume
- 513
- Issue
- 7518
- Pages
- 422-425
- ISSN
- 0028-0836
- 1476-4687
- PMC
- PMC4227286
- Cited by
- 357
- References
- 7
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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