Lipid landscapes and pipelines in membrane homeostasis
Abstract
The lipid composition of cellular organelles is tailored to suit their specialized tasks. A fundamental transition in the lipid landscape divides the secretory pathway in early and late membrane territories, allowing an adaptation from biogenic to barrier functions. Defending the contrasting features of these territories against erosion by vesicular traffic poses a major logistical problem. To this end, cells evolved a network of lipid composition sensors and pipelines along which lipids are moved by non-vesicular mechanisms. We review recent insights into the molecular basis of this regulatory network and consider examples in which malfunction of its components leads to system failure and disease.
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A shift in the ratio of specific GPL subclasses can affect membrane properties such as its fluidity and curvature, which can further modulate neuronal excitability.
“In addition, a shift in the ratio of specific GPL subclasses can affect membrane properties such as its fluidity and curvature, 25 which can further modulate neuronal excitability.45,47,71”
From Large neutral amino acid levels tune perinatal neuronal excitability and survival (2023) · cites this paper as [25]
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Large neutral amino acid levels tune perinatal neuronal excitability and survival
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- Authors
- Holthuis, J. C. M., & Menon, A. K.
- Affiliations
- Osnabrück University (DE)
- Weill Cornell Medicine (US)
- Corresponding author
- Holthuis, Joost C.M.
- Menon, Anant K.
- Venue
- Nature
- Published
- 2014-06
- Volume
- 510
- Issue
- 7503
- Pages
- 48-57
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2068749469
- Cited by
- 901
- References
- 1
- Citations by year
- 2026: 75 · 2025: 69 · 2024: 50 · 2023: 75 · 2022: 87 · 2021: 86 · 2020: 78 · 2019: 89 · 2018: 72 · 2017: 68 · 2016: 79 · 2015: 55 · 2014: 17 · 2012: 1
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM071041, GM071041)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- membrane lipid composition, lipid homeostasis, secretory pathway, non-vesicular lipid transport, lipid trafficking, membrane biogenesis, membrane barrier function
- MeSH terms
- Animals, Carrier Proteins, Homeostasis, Humans, Intracellular Membranes, Lipid Bilayers, Membrane Lipids, Sphingolipids, Organelles
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