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Biochemical transformation of bacterial lipopolysaccharides by acyloxyacyl hydrolase reduces host injury and promotes recovery

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Internalization of the Membrane Attack Complex Triggers NLRP3 Inflammasome Activation and IL-1β Secretion in Human Macrophages

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Exosomes Regulate NLRP3 Inflammasome in Diseases

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Engineering catalytic dephosphorylation reaction for endotoxin inactivation

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The Controversial Role of LPS in Platelet Activation In Vitro

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Targeting pyroptosis in breast cancer: biological functions and therapeutic potentials on It

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Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme

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Development of an Ex Vivo Tissue Platform To Study the Human Lung Response to Coxiella burnetii

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Theaflavin mitigates acute gouty peritonitis and septic organ injury in mice by suppressing NLRP3 inflammasome assembly

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Redox regulation of the NLRP3-mediated inflammation and pyroptosis

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hGBP1 Coordinates Chlamydia Restriction and Inflammasome Activation through Sequential GTP Hydrolysis

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Secretoglobin 3A2 eliminates human cancer cells through pyroptosis

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The LPS induced pyroptosis exacerbates BMPR2 signaling deficiency to potentiate SLE‐PAH

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Inhibition of NEK7 Suppressed Hepatocellular Carcinoma Progression by Mediating Cancer Cell Pyroptosis

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Regulation of Inflammatory Cell Death by Phosphorylation

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Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence

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Activation of the Absent in Melanoma 2 Inflammasome in Peripheral Blood Mononuclear Cells From Idiopathic Pulmonary Fibrosis Patients Leads to the Release of Pro-Fibrotic Mediators

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Cell Death and Skin Disease

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Immunodynamic Disruption in Sepsis: Mechanisms and Strategies for Personalized Immunomodulation

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Manipulation of the host cell death pathway byShigella

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Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice

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Antimicrobial inflammasomes: unified signalling against diverse bacterial pathogens

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The NACHT, LRR and PYD Domains-Containing protein 3 (NLRP3) Inflammasome Mediates Inflammation and Voiding Dysfunction in a Lipopolysaccharide-Induced Rat Model of Cystitis

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Heat-Clearing Chinese Medicines in Lipopolysaccharide-Induced Inflammation

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Impairment of the autophagy-lysosomal pathway and activation of pyroptosis in macular corneal dystrophy

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Shiga toxin suppresses noncanonical inflammasome responses to cytosolic LPS

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Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina

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Induction of pyroptotic cell death as a potential tool for cancer treatment

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Molecular regulation and therapeutic implications of cell death in pulmonary hypertension

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Primary Role for Toll-Like Receptor-Driven Tumor Necrosis Factor Rather than Cytosolic Immune Detection in Restricting Coxiella burnetii Phase II Replication within Mouse Macrophages

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Newcastle disease virus infection induces activation of the NLRP3 inflammasome

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Detecting lipopolysaccharide in the cytosol of mammalian cells: Lessons from MD-2/TLR4

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Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways

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Does Pyroptosis Play a Role in Inflammasome-Related Disorders?

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Pyroptosis in bone loss

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Multiple TLRs elicit alternative NLRP3 inflammasome activation in primary human monocytes independent of RIPK1 kinase activity

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CHOP-mediated Gasdermin E expression promotes pyroptosis, inflammation, and mitochondrial damage in renal ischemia-reperfusion injury

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Inflammasome Molecular Insights in Autoimmune Diseases

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Apoptosis‐Sensitizing Tumor Nanomedicine by Regulating Pyroptosis‐Associated Inflammatory Cell Death

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De novo design of protein minibinder agonists of TLR3

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Cell death in acute lung injury: caspase-regulated apoptosis, pyroptosis, necroptosis, and PANoptosis

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NLRP3 Inflammasome-Mediated Pyroptosis in Diabetic Nephropathy: Pathogenic Mechanisms and Therapeutic Targets

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Stearoyl Lysophosphatidylcholine Inhibits Endotoxin-Induced Caspase-11 Activation

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Mesenchymal Stromal Cells Directly Promote Inflammation by Canonical NLRP3 and Non-canonical Caspase-11 Inflammasomes

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Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis

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Crystal structure of caspase-11 CARD provides insights into caspase-11 activation

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Biological Functions of Gasdermins in Cancer: From Molecular Mechanisms to Therapeutic Potential

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Shigella OspC3 Suppresses Murine Cytosolic LPS Sensing

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Inflammasomes and Colorectal Cancer

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Samotolisib Attenuates Acute Liver Injury Through Inhibiting Caspase-11-Mediated Pyroptosis Via Regulating E3 Ubiquitin Ligase Nedd4

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Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants

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Inflammasome Complexes: Crucial mediators in osteoimmunology and bone diseases.

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Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐NLRP3 inflammasomes

Tuipulotu, D. E., Feng, S., Pandey, A., Zhao, A., Ngo, C., Mathur, A., Lee, J., Shen, C. X., Fox, D., Xue, Y., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022112558 · Cited by 32

Fight or flight

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Interferon-γ in Salmonella pathogenesis: New tricks for an old dog

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Distinct Roles of the Antiapoptotic Effectors NleB and NleF from Enteropathogenic Escherichia coli

Pollock, G. L., Oates, C. V. L., Giogha, C., Lung, T. W. F., Ong, S. Y., Pearson, J. S., & Hartland, E. L. (2017) · Infection and Immunity · doi:10.1128/iai.01071-16 · Cited by 32

NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review)

Ciążyńska, M. A., Bednarski, I. A., Wódz, K., Narbutt, J., & Lesiak, A. (2020) · Oncology Letters · doi:10.3892/ol.2020.11284 · Cited by 33

Dual functional β-peptide polymer-modified resin beads for bacterial killing and endotoxin adsorption

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Inflammasome activation by Gram-positive bacteria: Mechanisms of activation and regulation

Keestra-Gounder, A. M., & Nagao, P. E. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1075834 · Cited by 33

Unconventional protein secretion by gasdermin pores

Brož, P. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101811 · Cited by 32

Molecular Activation of NLRP3 Inflammasome by Particles and Crystals: A Continuing Challenge of Immunology and Toxicology

Ma, Q., & Lim, C. S. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-031023-125300 · Cited by 36

New insights into Gasdermin D pore formation

Kappelhoff, S., Margheritis, E. G., & Cosentino, K. (2024) · Biochemical Society Transactions · doi:10.1042/bst20230549 · Cited by 31

Host Cell S Phase Restricts Legionella pneumophila Intracellular Replication by Destabilizing the Membrane-Bound Replication Compartment

Jesús-Díaz, D. A. D., Murphy, C. S., Sol, A., Dorer, M. S., & Isberg, R. R. (2017) · mBio · doi:10.1128/mbio.02345-16 · Cited by 31

Transcriptome signature identifies distinct cervical pathways induced in lipopolysaccharide-mediated preterm birth†,‡

Willcockson, A. R., Nandu, T. S., Liu, C., Nallasamy, S., Kraus, W. L., & Mahendroo, M. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox180 · Cited by 31

Impaired phagocytosis directs human monocyte activation in response to fungal derived β‐glucan particles

Camilli, G., Eren, E., Williams, D. L., Aimanianda, V., Meunier, É., & Quintin, J. (2018) · European Journal of Immunology · doi:10.1002/eji.201747224 · Cited by 33

The Emerging Role of Inflammasomes as Central Mediators in Inflammatory Bladder Pathology

Inouye, B. M., Hughes, F. M., Sexton, S. J., & Purves, J. T. (2018) · Current Urology · doi:10.1159/000447196 · Cited by 34

Protective effect of Ketone musk on LPS/ATP-induced pyroptosis in J774A.1 cells through suppressing NLRP3/GSDMD pathway

He, C., Zhao, Y. P., Jiang, X., Liang, X., Yin, L., Yin, Z., Geng, Y., Zhong, Z., Song, X., Zou, Y., et al. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.03.054 · Cited by 31

Activation of CB2 receptor inhibits pyroptosis and subsequently ameliorates cecal ligation and puncture-induced sepsis

Zhang, B., Zheng, F., Liu, A., Li, Z., Zheng, F. Y., Liu, Q., Liu, Y., Chen, K., Wang, Y., Zhang, Z., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108038 · Cited by 31

The Role of Inflammasome Activation in Early HIV Infection

Ekabe, C. J., Asaba, C. N., Kehbila, J., & Franck, N. C. (2021) · Journal of Immunology Research · doi:10.1155/2021/1487287 · Cited by 32

A novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway

Ma, C., Ma, X., Jiang, B.-G., Pan, H., Liao, X., Zhang, L., Li, W., Luo, Y., Shen, Z., Cheng, X., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00752-8 · Cited by 33

Variation in blood microbial lipopolysaccharide (LPS) contributes to immune reconstitution in response to suppressive antiretroviral therapy in HIV

Luo, Z., Health, S. L., Li, M., Yang, H., Wu, Y., Collins, M., Deeks, S. G., Martin, J. N., Scott, A. J., & Jiang, W. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104037 · Cited by 31

Development of sulfonamide-based NLRP3 inhibitors: Further modifications and optimization through structure-activity relationship studies

Xu, Y., Xu, Y., Blevins, H., Guo, C., Biby, S., Wang, X., Wang, C., & Zhang, S. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114468 · Cited by 31

Microglial pyroptosis: Therapeutic target in secondary brain injury following intracerebral hemorrhage

Gu, L., Sun, M., Li, R., Tao, Y., Xu, L., Zhang, X., Yuan, Y., & Xie, Z. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.971469 · Cited by 31

CgCaspase-3 activates the translocation of CgGSDME in haemocytes of Pacific oyster Crassostrea gigas

Li, X., Yan, X., Leng, J., Wang, W., Li, Y., Yang, C., Sun, J., Wang, L., & Song, L. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.10.036 · Cited by 31

Mechanisms of NLRP3 inflammasome in rheumatoid arthritis and osteoarthritis and the effects of traditional Chinese medicine

Zhang, R., Han, L., Lin, W., Ba, X., Yan, J., Li, T., Yang, Y., Huang, Y., Huang, Y., Qin, K., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117432 · Cited by 32

Targeting Cell Death Pathways for Therapeutic Intervention in Kidney Diseases

Garg, J. P., & Vucic, D. (2016) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2016.03.003 · Cited by 33

The dangerous liaisons in innate immunity involving recombinant proteins and endotoxins: Examples from the literature and the Leptospira field

Bonhomme, D., Cavaillon, J., & Werts, C. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105506 · Cited by 31

The protease caspase-1: Activation pathways and functions

Zhen, H., Hu, Y., Liu, X., Fan, G., & Zhao, S. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149978 · Cited by 32

Caspase-11 Modulates Inflammation and AttenuatesToxoplasma gondiiPathogenesis

Coutermarsh‐Ott, S. L., Doran, J. T., Campbell, C., Williams, T. M., Lindsay, D. S., & Allen, I. C. (2016) · Mediators of Inflammation · doi:10.1155/2016/9848263 · Cited by 30

Caspases orchestrate microglia instrumental functions

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Pyroptosis of MCF7 Cells Induced by the Secreted Factors of hUCMSCs

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