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Non-canonical inflammasome activation targets caspase-11

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Lipid A Modification Systems in Gram-Negative Bacteria

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The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

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Salmonella-induced inflammasome activation in humans

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The Type II Secretion System of Legionella pneumophila Dampens the MyD88 and Toll-Like Receptor 2 Signaling Pathway in Infected Human Macrophages

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Multiple Pseudomonas species secrete exolysin‐like toxins and provoke Caspase‐1‐dependent macrophage death

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AGER-Mediated Lipid Peroxidation Drives Caspase-11 Inflammasome Activation in Sepsis

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Shigella infection and host cell death: a double-edged sword for the host and pathogen survival

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Inflammasome activation by Salmonella

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Pyroptosis and Sarcopenia: Frontier Perspective of Disease Mechanism

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Molecular Mechanisms of Inflammasome in Ischemic Stroke Pathogenesis

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IL-18 and Subcapsular Lymph Node Macrophages are Essential for Enhanced B Cell Responses with TLR4 Agonist Adjuvants

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Current knowledge of pyroptosis in heart diseases

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Cancer-associated pyroptosis: A new license to kill tumor

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Caspase‐6 is a key regulator of cross‐talk signal way in PANoptosis in cancer

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Endoplasmic reticulum stress promotes caspase-1-dependent acinar cell pyroptosis through the PERK pathway to aggravate acute pancreatitis

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Mechanisms of Alveolar Type 2 Epithelial Cell Death During Acute Lung Injury

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Programmed cell death in tumor immunity: mechanistic insights and clinical implications

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Influence of an Allergen-Specific Th17 Response on Remodeling of the Airways

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Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study

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Caspase-11 deficiency impairs neutrophil recruitment and bacterial clearance in the early stage of pulmonary Klebsiella pneumoniae infection

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Regulation of Hepatic Inflammation via Macrophage Cell Death

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Caspase-4 disaggregates lipopolysaccharide micelles via LPS-CARD interaction

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Recognition of Intracellular Bacteria by Inflammasomes

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Anastasis: Return Journey from Cell Death

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Nanoagonist‐Mediated GSDME‐Dependent Pyroptosis Remodels the Inflammatory Microenvironment for Tumor Photoimmunotherapy

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Programmed Cell Death in the Evolutionary Race against Bacterial Virulence FactorsPreprint

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Chronic Intestinal Inflammation Suppresses Brain Activity by Inducing Neuroinflammation in Mice

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IFN-γ Facilitates Corneal Epithelial Cell Pyroptosis Through the JAK2/STAT1 Pathway in Dry Eye

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Pyroptosis and inflammasomes in cancer and inflammation

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Research progress on pyroptosis and its effect on the central nervous system

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Tackling cuproptosis: from metabolic rewiring to therapeutic exploitation in cancer

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Salmonella and the Inflammasome: Battle for Intracellular Dominance

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Bacterial secretion systems and regulation of inflammasome activation

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Immunity to uropathogens: the emerging roles of inflammasomes

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The inflammasomes, immune guardians at defence barriers

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Regulatory roles of ginseng on inflammatory caspases, executioners of inflammasome activation

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Porphyromonas gingivalis lipopolysaccharide affects oral epithelial connections via pyroptosis

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Regulated cell death in cisplatin-induced AKI: relevance of myo-inositol metabolism

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Inflammasomes in dendritic cells: Friend or foe?

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Anti-Inflammation and Anti-Pyroptosis Activities of Mangiferin via Suppressing NF-κB/NLRP3/GSDMD Signaling Cascades

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Is the inflammasome relevant for epithelial cell function?

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A Comparative Review of Pyroptosis in Mammals and Fish

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Shigella IpaH9.8 limits GBP1-dependent LPS release from intracytosolic bacteria to suppress caspase-4 activation

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Pyroptosis-related crosstalk in osteoarthritis: Macrophages, fibroblast-like synoviocytes and chondrocytes

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Therapeutic targeting of cell death-immune crosstalk in cancer to rewire the tumor immune microenvironment

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The kinase activity of PKR represses inflammasome activity

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Activation and pathogenic manipulation of the sensors of the innate immune system

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Oral Administration of a Select Mixture of Lactobacillus and Bacillus Alleviates Inflammation and Maintains Mucosal Barrier Integrity in the Ileum of Pigs Challenged with Salmonella Infantis

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Caspase‐7 mediates caspase‐1‐induced apoptosis independently of Bid

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Dual function of a turbot inflammatory caspase in mediating both canonical and non-canonical inflammasome activation

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Intestinal Epithelial Responses to IL-17 in Adult Stem Cell-derived Human Intestinal Organoids

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Baicalein Suppresses NLRP3 and AIM2 Inflammasome-Mediated Pyroptosis in Macrophages Infected by Mycobacterium tuberculosis via Induced Autophagy

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The Brucella effector protein TcpB induces degradation of inflammatory caspases and thereby subverts non-canonical inflammasome activation in macrophages

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HMGB1 plays an important role in pyroptosis induced blood brain barrier breakdown in diabetes-associated cognitive decline

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Roles of pyroptosis in atherosclerosis pathogenesis

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Pyroptosis in health and disease

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Mechanism and role of regulated cell death in tumor immunity and immunotherapy

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Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts

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GSDME as an executioner of chemotherapy-induced cell death

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CASP4 gene silencing in epithelial cancer cells leads to impairment of cell migration, cell-matrix adhesion and tissue invasion

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AIM2 Inflammasome Activation Leads to IL-1α and TGF-β Release From Exacerbated Chronic Obstructive Pulmonary Disease-Derived Peripheral Blood Mononuclear Cells

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Caspase-11 signaling enhances graft-versus-host disease

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Approaching Neutrophil Pyroptosis

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Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy

Li, W., Sun, J., Zhou, X., Lu, Y., Cui, W., & Miao, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.780790 · Cited by 40

Bone marrow mesenchymal stem cells-derived exosomes containing miR-539-5p inhibit pyroptosis through NLRP3/caspase-1 signalling to alleviate inflammatory bowel disease

Wang, D., Xue, H. Y., Tan, J., Liu, P., Qiao, C., Pang, C., & Zhang, L. (2022) · Inflammation Research · doi:10.1007/s00011-022-01577-z · Cited by 38

Mechanism of pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional Chinese medicine

Liao, Y., Wang, X., Huang, L., Qian, H., & Liu, W. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1122104 · Cited by 37

The noncanonical inflammasome-induced pyroptosis and septic shock

Wu, J., Cai, J., Tang, Y., & Lü, B. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101844 · Cited by 37

Targeting pyroptosis to treat ischemic stroke: From molecular pathways to treatment strategy

Li, L., Shi, C., Dong, F., Xu, G., Lei, M., & Zhang, F. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112168 · Cited by 38

Development of covalent NLRP3 inflammasome inhibitors: Chemistry and biological activity

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NLRP6 self-assembles into a linear molecular platform following LPS binding and ATP stimulation

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Deep-sea microbes as tools to refine the rules of innate immune pattern recognition

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Potential therapeutic role of pyroptosis mediated by the NLRP3 inflammasome in type 2 diabetes and its complications

Li, X., Xiao, G.-Y., Guo, T., Song, Y., & Li, Q. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.986565 · Cited by 38

An updated view on the structure and function of PYRIN domains

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Flow signaling and atherosclerosis

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Silencing ubiquitin‐conjugating enzyme 2C inhibits proliferation and epithelial–mesenchymal transition in pancreatic ductal adenocarcinoma

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Evoking pyroptosis with nanomaterials for cancer immunotherapy: Current boom and novel outlook

Sun, Z., & Wang, W.-D. (2022) · Nano TransMed · doi:10.26599/ntm.2022.9130001 · Cited by 36

The role of HMGB1 in COVID‐19‐induced cytokine storm and its potential therapeutic targets: A review

Wulandari, S., Hartono, H., & Wibawa, T. (2022) · Immunology · doi:10.1111/imm.13623 · Cited by 38

The Potential of NLRP3 Inflammasome as a Therapeutic Target in Neurological Diseases

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Evolution of LPS recognition and signaling: The bony fish perspective

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Medicinal chemistry strategies targeting NLRP3 inflammasome pathway: A recent update from 2019 to mid-2023

Duan, M., Sun, L., He, X., Wang, Z., Hou, Y., & Zhao, Y. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115750 · Cited by 36

Force-induced Caspase-1-dependent pyroptosis regulates orthodontic tooth movement

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Structural transitions enable interleukin-18 maturation and signaling

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NLRP3 inflammasome activity and periodontal disease pathogenesis–A bidirectional relationship

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Pyroptosis: A spoiler of peaceful coexistence between cells in degenerative bone and joint diseases

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Role of Lipopolysaccharides in the Inflammation and Pyroptosis of Alveolar Epithelial Cells in Acute Lung Injury and Acute Respiratory Distress Syndrome

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The human-specificCASP4gene product contributes to Alzheimer-related synaptic and behavioural deficits

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Accumulation mode particles and LPS exposure induce TLR-4 dependent and independent inflammatory responses in the lung

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3‑Bromo‑5‑(ethoxymethyl)‑1,2‑benzenediol inhibits LPS-induced pro-inflammatory responses by preventing ROS production and downregulating NF-κB in vitro and in a zebrafish model

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