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Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation
Open accessAbstract
The proliferation of genetically modified mouse models has exposed phenotypic variation between investigators and institutions that has been challenging to control. In many cases, the microbiota is the presumed cause of the variation. Current solutions to account for phenotypic variability include littermate and maternal controls or defined microbial consortia in gnotobiotic mice. In conventionally raised mice, the microbiome is transmitted from the dam. Here we show that microbially driven dichotomous faecal immunoglobulin-A (IgA) levels in wild-type mice within the same facility mimic the effects of chromosomal mutations. We observe in multiple facilities that vertically transmissible bacteria in IgA-low mice dominantly lower faecal IgA levels in IgA-high mice after co-housing or faecal transplantation. In response to injury, IgA-low mice show increased damage that is transferable by faecal transplantation and driven by faecal IgA differences. We find that bacteria from IgA-low mice degrade the secretory component of secretory IgA as well as IgA itself. These data indicate that phenotypic comparisons between mice must take into account the non-chromosomal hereditary variation between different breeders. We propose faecal IgA as one marker of microbial variability and conclude that co-housing and/or faecal transplantation enables analysis of progeny from different dams.
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“It has been shown that the intestinal microbiota can degrade IgA, which plays a key role in mucosal immunology, and mice with documented degradation of secretory IgA are more susceptible to chemically-induced colitis.152”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [152]
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Cites
NIH Image to ImageJ: 25 years of image analysis
Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 21,098
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192
Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample
Caporaso, J. G., Lauber, C. L., Walters, W. A., Berg-Lyons, D., Lozupone, C., Turnbaugh, P. J., Fierer, N., & Knight, R. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000080107 · Cited by 9,944
McDonald, D. T., Price, M. N., Goodrich, J. K., Nawrocki, E. P., DeSantis, T. Z., Probst, A. J., Andersen, G. L., Knight, R. D., & Hugenholtz, P. (2011) · The ISME Journal · doi:10.1038/ismej.2011.139 · Cited by 5,144
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Unravelling the effects of the environment and host genotype on the gut microbiome
Spor, A., Koren, O., & Ley, R. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2540 · Cited by 1,509
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Azhari, A., Azizan, F., & Esposito, G. (2018) · Developmental Psychobiology · doi:10.1002/dev.21803 · Cited by 52
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Yang, C., Chen-Liaw, A., Spindler, M. P., Tortorella, D., Moran, T. M., Cerutti, A., & Faith, J. J. (2022) · Science Immunology · doi:10.1126/sciimmunol.abg3208 · Cited by 44
Peterson, S. T., Kennedy, E. A., Brigleb, P. H., Taylor, G. M., Urbanek, K., Bricker, T. L., Lee, S., Shin, H., Dermody, T. S., Boon, A. C. M., et al. (2019) · Journal of Virology · doi:10.1128/jvi.01073-19 · Cited by 46
Self-citationZhang, S., Zhou, R., Xie, X., Xiong, S., Li, L., & Li, Y. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.122905 · Cited by 45
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Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2015) · Journal of NeuroVirology · doi:10.1007/s13365-015-0355-x · Cited by 41
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Li, R., Mao, Z., Ye, X., & Zuo, T. (2021) · Microorganisms · doi:10.3390/microorganisms9051017 · Cited by 40
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Yu, Y., Lin, X., Feng, F., Wei, Y., Wei, S., Gong, Y., Guo, C., Wang, Q., Shuai, P., Wang, T., et al. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115947 · Cited by 40
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Borrego-Ruiz, A., & Borrego, J. J. (2024) · Children · doi:10.3390/children11070796 · Cited by 42
Bice, B. D., Stephens, M. R., Georges, S. J., Venancio, A. R., Bermant, P. C., Warncke, A. V., Affolter, K. E., Hidalgo, J. R., & Angus-Hill, M. L. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.006 · Cited by 40
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Shi, Z., & Gewirtz, A. T. (2018) · Viruses · doi:10.3390/v10030122 · Cited by 43
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Messer, J. S., Liechty, E. R., Vogel, O. A., & Chang, E. B. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.138 · Cited by 41
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Yoon, Y. M., Hrusch, C. L., Fei, N., Barrón, G. M., Mills, K. A. M., Hollinger, M. K., Velez, T. E., Leone, V., Chang, E. B., & Sperling, A. I. (2022) · Respiratory Research · doi:10.1186/s12931-022-02264-7 · Cited by 36
Richmond, B. W., Mansouri, S., Serezani, A. P. M., Novitskiy, S. V., Blackburn, J. B., Du, R., Fuseini, H., Gutor, S. S., Han, W., Schaff, J., et al. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-00344-9 · Cited by 36
Dietary Magnesium Alleviates Experimental Murine Colitis through Modulation of Gut Microbiota
CHIERICO, F. D., Trapani, V., Petito, V., Reddel, S., Pietropaolo, G., Graziani, C., Masi, L., Gasbarrini, A., Putignani, L., Scaldaferri, F., et al. (2021) · Nutrients · doi:10.3390/nu13124188 · Cited by 36
A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency
Lu, Q., Hitch, T. C. A., Zhou, J. Y., Dwidar, M., Sangwan, N., Lawrence, D., Nolan, L. S., Espenschied, S. T., Newhall, K. P., Han, Y., et al. (2024) · Science · doi:10.1126/science.adk2536 · Cited by 39
Self-citationPolicing of gut microbiota by the adaptive immune system
Dollé, L., Tran, H. Q., Etienne‐Mesmin, L., & Chassaing, B. (2016) · BMC Medicine · doi:10.1186/s12916-016-0573-y · Cited by 39
Rojas-Velázquez, L., Moran, P. A., Serrano-Vázquez, A., Portillo-Bobadilla, T., González, E., Pérez-Juárez, H., Hernández, E., Partida‐Rodríguez, O., Nieves, M., Padilla, A., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.967724 · Cited by 34
The Local Defender and Functional Mediator: Gut Microbiome
Yang, H., & Duan, Z. (2018) · Digestion · doi:10.1159/000484687 · Cited by 35
Chen, Y., Jin, Y. J., Stanton, C., Ross, R. P., Wang, Z., Zhao, J., Zhang, H., Yang, B. K., & Chen, W. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104245 · Cited by 35
Pederzoli, F., Riba, M., Venegoni, C., Marandino, L., Bandini, M., Alchera, E., Locatelli, I., Raggi, D., Giannatempo, P., Provero, P., et al. (2024) · European Urology · doi:10.1016/j.eururo.2023.12.014 · Cited by 33
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Morgan, T. J. H., & Feldman, M. W. (2024) · Nature Human Behaviour · doi:10.1038/s41562-024-02035-y · Cited by 40
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Takeuchi, T., & Ohno, H. (2021) · International Immunology · doi:10.1093/intimm/dxab049 · Cited by 35
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Zhou, J., He, F., Yang, F., Yang, Z., Xie, Y., Zhou, S., Liang, J., Xu, R., Wang, Y., Guo, H., et al. (2017) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2017.10.009 · Cited by 35
Li, C., Lam, E., Perez‐Shibayama, C., Ward, L. A., Zhang, J., Lee, D. S. W., Nguyen, A., Ahmed, M., Brownlie, E., Korneev, K. V., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aax1027 · Cited by 33
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Richter, H., Gover, O., & Schwartz, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310634 · Cited by 32
Karl, J. P., Armstrong, N. J., McClung, H. L., Player, R. A., Rood, J. C., Racicot, K., Soares, J. W., & Montain, S. J. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108217 · Cited by 32
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Brawner, K. M., Yeramilli, V. A., Kennedy, B. A., Patel, R. K., & Martin, C. A. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.07.008 · Cited by 30
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Chan, C. C., Harley, I. T. W., Pfluger, P. T., Trompette, A., Stankiewicz, T. E., Allen, J. L., Moreno‐Fernandez, M. E., Damen, M. S. M. A., Oates, J. R., Alarcon, P. C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23084-1 · Cited by 30
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Yang, X., Xiao, H., Zeng, Y., Huang, L., Ji, K., Deng, D., Yang, W., & Liu, L. (2021) · BioMed Research International · doi:10.1155/2021/9979511 · Cited by 31
Vatanen, T., de Beaufort, C. E., Marcovecchio, M. L., Overbergh, L., Brunak, S., Peakman, M., Mathieu, C., & Knip, M. (2024) · Diabetologia · doi:10.1007/s00125-024-06192-7 · Cited by 27
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Chen, X., Liu, S., Song, H., Yuan, C., & Li, J. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.139015 · Cited by 26
Mandal, R. K., Denny, J. E., Waide, M. L., Li, Q., Bhutiani, N., Anderson, C. D., Baby, B. V., Jala, V. R., Egilmez, N. K., & Schmidt, N. W. (2020) · BMC Biology · doi:10.1186/s12915-020-00810-7 · Cited by 29
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Haniuda, K., Gommerman, J. L., & Reich, H. N. (2021) · Seminars in Immunopathology · doi:10.1007/s00281-021-00893-6 · Cited by 26
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Zhang, S., Han, Y., Schofield, W. B., Nicosia, M., Karell, P. E., Newhall, K. P., Zhou, J. Y., Musich, R. J., Pan, S., Valujskikh, A., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.09.001 · Cited by 25
Self-citationThe microbiome and the immune system in critical illness
Miniet, A. A., Grunwell, J. R., & Coopersmith, C. M. (2021) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000800 · Cited by 27
Vallier, M., Ségurens, B., Larsonneur, E., Meyer, V., Ferreira, S., Caloustian, C., Deleuze, J., Dougados, M., Chamaillard, M., & Miceli-Richard, C. (2023) · RMD Open · doi:10.1136/rmdopen-2022-002794 · Cited by 22
Wang, D., Wang, W., Bing, X., Xu, C., Qiu, J., Shen, J., Huang, J., Li, J., Liu, P., & Xie, B. (2023) · FEBS Open Bio · doi:10.1002/2211-5463.13673 · Cited by 24
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Yang, J., Xiong, P., Bai, L., Zhang, Z., Zhou, Y. C., Chen, C., Xie, Z., Xu, Y., Chen, M., Wang, H., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.765414 · Cited by 22
Reider, S., Watschinger, C., Längle, J., Pachmann, U., Przysiecki, N., Pfister, A., Zollner, A., Tilg, H., Plattner, S., & Moschen, A. R. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091479 · Cited by 22
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Self-citationAntimicrobial therapy during cancer treatment: Beyond antibacterial effects
Ghanem, S., Kim, C. J., Dutta, D., Salifu, M. O., & Lim, S. H. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13238 · Cited by 23
Ma, K., Chen, J., Kuang, L., Bi, J., Cheng, J., Li, F., Sun, X., Nie, X., Liu, Y., Luo, R., et al. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/1304397 · Cited by 21
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Bessman, N. J., & Sonnenberg, G. F. (2016) · Immunological Reviews · doi:10.1111/imr.12425 · Cited by 21
Sun, H., Bi, J., Lei, Q., Wan, X., Jiang, T., Wu, C., & Wang, X. (2017) · International Journal of Surgery · doi:10.1016/j.ijsu.2017.12.011 · Cited by 21
Miyoshi, J., Nobutani, K., Musch, M. W., Ringus, D. L., Hubert, N. A., Yamamoto, M., Kase, Y., Nishiyama, M., & Chang, E. B. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/7415975 · Cited by 21
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Treichel, N. S., Prevoršek, Z., Mrak, V., Kostrić, M., Vestergaard, G., Foesel, B. U., Pfeiffer, S., Stres, B., Schöler, A., & Schloter, M. (2019) · Microbial Ecology · doi:10.1007/s00248-019-01317-7 · Cited by 22
Gupta, S., Basu, S., Bal, V., Rath, S., & George, A. (2019) · Immunology · doi:10.1111/imm.13091 · Cited by 21
Abo, H., Muraki, A., Harusato, A., Imura, T., Suzuki, M., Takahashi, K., Denning, T. L., & Kawashima, H. (2023) · JCI Insight · doi:10.1172/jci.insight.165944 · Cited by 20
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Bertin, B., Foligné, B., Ley, D., Lésage, J., Béghin, L., Morcel, J., Gottrand, F., & Hermann, E. (2023) · Nutrients · doi:10.3390/nu15245103 · Cited by 21
Sheh, A., Artim, S. C., Burns, M. A., Molina-Mora, J. A., Lee, M. A., Dzink-Fox, J., Muthupalani, S., & Fox, J. G. (2022) · Scientific Reports · doi:10.1038/s41598-022-08255-4 · Cited by 24
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Yamashita, A., Inamine, T., Suzuki, S., Fukuda, S., Unoike, M., Kawafuchi, Y., Machida, H., Isomoto, H., Nakao, K., & Tsukamoto, K. (2019) · Immunology Letters · doi:10.1016/j.imlet.2019.01.007 · Cited by 20
FitzPatrick, R. D., Kennedy, M. H. E., Lawrence, K. M., Gauthier, C. M., Moeller, B. E., Robinson, A. N., & Reynolds, L. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.557960 · Cited by 19
Mahdally, S. M., Izquierdo, M., Viscardi, R. M., Magder, L. S., Crowley, H. M., Bafford, A. C., Drachenberg, C. B., Farfán, M. J., Fasano, A., Sztein, M. B., et al. (2023) · Clinical & Experimental Immunology · doi:10.1093/cei/uxad042 · Cited by 17
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Zhao, L., Hu, S., Davila, M. L., Yang, J., Lin, Y., Albanese, J. M., Lo, Y., Wang, Y., Kennett, M. J., Liu, Q., et al. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0333-3 · Cited by 17
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di Iulio, J., Bartha, I., Spreafico, R., Virgin, H. W., & Telenti, A. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2022486118 · Cited by 16
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Papotto, P. H., Yılmaz, B., Pimenta, G. F., Mensurado, S., Cunha, C., Fiala, G. J., da Costa, D. G., Gonçalves‐Sousa, N., Chan, B. H. K., Blankenhaus, B., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112074 · Cited by 15
Ta, A., Ollberding, N. J., Karns, R. A., Haberman, Y., Alazraki, A. L., Hercules, D., Baldassano, R. N., Markowitz, J. F., Heyman, M. B., Kim, S. S. Y., et al. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa339 · Cited by 15
Jiang, C., Deng, S., Ma, X., Song, J., Li, J., & Yuan, E. (2024) · International Journal of Hematology · doi:10.1007/s12185-024-03777-1 · Cited by 13
Wang, Z., Song, B., Yao, J., Li, X., Zhang, Y., Tang, Z., & Yi, G. (2024) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-024-01053-0 · Cited by 16
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Scheithauer, T. P. M., Bakker, G. J., Winkelmeijer, M., Davids, M., Nieuwdorp, M., van Raalte, D. H., & Herrema, H. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1875109 · Cited by 14
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Ventura, M., Milani, C., Lugli, G. A., & van Sinderen, D. (2018) · Microbial Biotechnology · doi:10.1111/1751-7915.13334 · Cited by 12
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de Aguiar, C. F., Castoldi, Â., Amano, M. T., Ignácio, A., Terra, F. F., Cruz, M. C., Felizardo, R. J. F., Braga, T. T., Davanzo, G. G., Gambarini, V. M. D. O., et al. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz300 · Cited by 13
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Lai, C., Bagadia, P., Barisas, D. A. G., Jarjour, N. N., Wong, R., Ohara, T. E., Muegge, B. D., Lu, Q., Xiong, S., Edelson, B. T., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200278 · Cited by 11
Self-citationGenetic regulation of antibody responsiveness to immunization in substrains of BALB /c mice
Poyntz, H., Jones, A., Jáuregui, R., Young, W., Gestin, A., Mooney, A., Lamiable, O., Altermann, E., Schmidt, A., Gasser, O., et al. (2018) · Immunology and Cell Biology · doi:10.1111/imcb.12199 · Cited by 10
Krueger, K., Marr, I., Dobler, A., & Palme, R. (2019) · Conservation Physiology · doi:10.1093/conphys/coz065 · Cited by 11
Yang, W., Xi, C., Yao, H., Yuan, Q., Zhang, J., Chen, Q., Wu, G., & Hu, J. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1304218 · Cited by 11
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Pu, A., Lee, D. S. W., Isho, B., Naouar, I., & Gommerman, J. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.742173 · Cited by 10
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Metadata
- Authors
- Moon, C., Baldridge, M. T., Wallace, M. A., Burnham, C.-A. D., Virgin, H. W., & Stappenbeck, T. S.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Virgin, Herbert W.
- Stappenbeck, Thaddeus S.
- ORCID
- Venue
- Nature
- Published
- 2015-02-16
- Volume
- 521
- Issue
- 7550
- Pages
- 90-93
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4425643
- OpenAlex
- W2086224292
- Cited by
- 268
- References
- 36
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 24 · 2023: 22 · 2022: 18 · 2021: 37 · 2020: 29 · 2019: 27 · 2018: 24 · 2017: 21 · 2016: 28 · 2015: 13
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health (R01OD011170)
- National Cancer Institute (T32CA009547)
- National Institute of Allergy and Infectious Diseases (AI08488702, T32AI007163)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK7161907, R01DK071619, R01DK097079, R01DK101354, P30DK052574)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR048335)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- vertical transmission, gut microbiota, phenotypic variability, wild-type mice, cohousing, secretory component, experimental replication, inter-laboratory variability, injury response
- MeSH terms
- Ampicillin, Anaerobiosis, Animals, Feces, Female, Immunoglobulin A, Immunoglobulin A, Secretory, Male, Mutation, Phenotype, Secretory Component, Reproducibility of Results, Biomarkers, Chromosomes, Mammalian, Mice, Microbiota
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