The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
N6-methyladenosine marks primary microRNAs for processing
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In the citing paper
“M6A was found to be enriched in primary microRNA transcripts.”
From HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events (2015) · cites this paper as Alarcon et al., 2015
In the citing paper
“suggest the existence of nuclear reader(s) of m6A that bind this mark and mediate nuclear processing events that are mechanistically distinct from RNA stability regulatory events that could occur in the cytoplasm.”
From HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events (2015) · cites this paper as Alarcon et al., 2015
In the citing paper
“our recent work implicating m6A/METTL3 in the processing of pri-miRNAs an event occurring in the nucleus also supported the existence of a nuclear ‘reader’ and effector of this mark (Alarcon et al., 2015).”
From HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events (2015) · cites this paper as Alarcon et al., 2015
In the citing paper
“The reduction in mature microRNA expression mirrored what was previously observed upon METTL3 depletion (Alarcon et al., 2015).”
From HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events (2015) · cites this paper as Alarcon et al., 2015
In the citing paper
“Reducing m6A levels by depleting the m6A writer METTL3 reduced the levels of the majority of expressed microRNAs”
From HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events (2015) · cites this paper as Alarcon et al., 2015
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Citations
Cites
Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
Meyer, K. D., Saletore, Y., Zumbo, P., Elemento, O., Mason, C. E., & Jaffrey, S. R. (2012) · Cell · doi:10.1016/j.cell.2012.05.003 · Cited by 4,223
Processing of primary microRNAs by the Microprocessor complex
Denli, A. M., Tops, B. B. J., Plasterk, R. H. A., Ketting, R. F., & Hannon, G. J. (2004) · Nature · doi:10.1038/nature03049 · Cited by 2,784
Research works printed but not linked: 22
- Gregory, R. I. et al. The Microprocessor complex mediates the genesis of microRNAs. Nature 432, 235–240 (2004) · DOI
- Han, J. et al. The Drosha–DGCR8 complex in primary microRNA processing. Genes Dev. 18, 3016–3027 (2004) · DOI
- Landthaler, M., Yalcin, A. & Tuschl, T. The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis. Curr. Biol. 14, 2162–2167 (2004) · DOI
- Han, J. et al. Molecular basis for the recognition of primary microRNAs by the Drosha–DGCR8 complex. Cell 125, 887–901 (2006) · DOI
- Elemento, O., Slonim, N. & Tavazoie, S. A universal framework for regulatory element discovery across all genomes and data types. Mol. Cell 28, 337–350 (2007) · DOI
- Wei, C. M. & Moss, B. Nucleotide sequences at the N6-methyladenosine sites of HeLa cell messenger ribonucleic acid. Biochemistry 16, 1672–1676 (1977) · DOI
- Dominissini, D. et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485, 201–206 (2012) · DOI · Paper page
- Bokar, J. A., Shambaugh, M. E., Polayes, D., Matera, A. G. & Rottman, F. M. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA 3, 1233–1247 (1997)
- Sibbritt, T., Patel, H. R. & Preiss, T. Mapping and significance of the mRNA methylome. RNA 4, 397–422 (2013)
- Camper, S. A., Albers, R. J., Coward, J. K. & Rottman, F. M. Effect of undermethylation on mRNA cytoplasmic appearance and half-life. Mol. Cell. Biol. 4, 538–543 (1984) · DOI · Paper page
- Carroll, S. M., Narayan, P. & Rottman, F. M. N6-methyladenosine residues in an intron-specific region of prolactin pre-mRNA. Mol. Cell. Biol. 10, 4456–4465 (1990) · DOI
- Thorvaldsdóttir, H., Robinson, J. T. & Mesirov, J. P. Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Brief. Bioinform. 14, 178–192 (2013) · DOI · Paper page
- Bujnicki, J. M., Feder, M., Radlinska, M. & Blumenthal, R. M. Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m6A methyltransferase. J. Mol. Evol. 55, 431–444 (2002) · DOI
- Chi, S. W., Zang, J. B., Mele, A. & Darnell, R. B. Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps. Nature 460, 479–486 (2009) · DOI · Paper page
- Pollard, K. S., Hubisz, M. J., Rosenbloom, K. R. & Siepel, A. Detection of nonneutral substitution rates on mammalian phylogenies. Genome Res. 20, 110–121 (2010) · DOI · Paper page
- Lee, Y. & Kim, V. N. In vitro and In vivo assays for the activity of Drosha complex. Methods Enzymol. 427, 87–106 (2007) · DOI
- Auyeung, V. C., Ulitsky, I., McGeary, S. E. & Bartel, D. P. Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing. Cell 152, 844–858 (2013) · DOI · Paper page
- Tavazoie, S. F. et al. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451, 147–152 (2008) · DOI
- Giannopoulou, E. G. & Elemento, O. An integrated ChIP-seq analysis platform with customizable workflows. BMC Bioinformatics 12, 277 (2011) · DOI
- Zhang, C. & Darnell, R. B. Mapping in vivo protein–RNA interactions at single-nucleotide resolution from HITS-CLIP data. Nature Biotechnol. 29, 607–614 (2011) · DOI
- Kim, S. W. et al. A sensitive non-radioactive northern blot method to detect small RNAs. Nucleic Acids Res. 38, e98 (2010) · DOI
- Batista, P. J. et al. m6A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell 15, 707–719 (2014) · DOI · Paper page
Cited by
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287
Reading, writing and erasing mRNA methylation
Zaccara, S., Ries, R. J., & Jaffrey, S. R. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0168-5 · Cited by 2,597
The role of m6A modification in the biological functions and diseases
Jiang, X., Liu, B., Nie, Z., Duan, L., Xiong, Q., Jin, Z., Yang, C., & Chen, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00450-x · Cited by 2,335
Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing
Xiao, W., Adhikari, S., Dahal, U., Chen, Y.-S., Hao, Y.-J., Sun, B.-F., Sun, H.-Y., Li, A., Ping, X.-L., Lai, W.-Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.012 · Cited by 2,054
HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
Alarcón, C. R., Goodarzi, H., Lee, H., Liu, X., Tavazoie, S., & Tavazoie, S. F. (2015) · Cell · doi:10.1016/j.cell.2015.08.011 · Cited by 1,514
Self-citation
Metadata
- Authors
- Alarcón, C. R., Lee, H., Goodarzi, H., Halberg, N., & Tavazoie, S. F.
- Venue
- Nature
- Published
- 2015-03
- Volume
- 519
- Issue
- 7544
- Pages
- 482-485
- ISSN
- 0028-0836
- 1476-4687
- PMC
- PMC4475635
- Cited by
- 1,315
- References
- 4
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.