Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing
Open accessAbstract
The regulatory role of N(6)-methyladenosine (m(6)A) and its nuclear binding protein YTHDC1 in pre-mRNA splicing remains an enigma. Here we show that YTHDC1 promotes exon inclusion in targeted mRNAs through recruiting pre-mRNA splicing factor SRSF3 (SRp20) while blocking SRSF10 (SRp38) mRNA binding. Transcriptome assay with PAR-CLIP-seq analysis revealed that YTHDC1-regulated exon-inclusion patterns were similar to those of SRSF3 but opposite of SRSF10. In vitro pull-down assay illustrated a competitive binding of SRSF3 and SRSF10 to YTHDC1. Moreover, YTHDC1 facilitates SRSF3 but represses SRSF10 in their nuclear speckle localization, RNA-binding affinity, and associated splicing events, dysregulation of which, as the result of YTHDC1 depletion, can be restored by reconstitution with wild-type, but not m(6)A-binding-defective, YTHDC1. Our findings provide the direct evidence that m(6)A reader YTHDC1 regulates mRNA splicing through recruiting and modulating pre-mRNA splicing factors for their access to the binding regions of targeted mRNAs.
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SRSF3 and YB-1 promote exon inclusion during alternative splicing.
“Interestingly, SRSF3 (43) and YB-1 (44) have also been shown to specifically promote exon inclusion during alternative splicing.”
From Discovery of a Novel CIP2A Variant (NOCIVA) with Clinical Relevance in Predicting TKI Resistance in Myeloid Leukemias (2021) · cites this paper as [43]
Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607 · see citing works
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
Dominissini, D., Moshitch-Moshkovitz, S., Schwartz, S., Salmon-Divon, M., Ungar, L., Osenberg, S., Cesarkas, K., Jacob-Hirsch, J., Amariglio, N., Kupiec, M., et al. (2012) · Nature · doi:10.1038/nature11112 · Cited by 4,884 · see citing works
N6-methyladenosine-dependent regulation of messenger RNA stability
Wang, X., Lu, Z., Gomez, A., Hon, G. C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q., Jia, G., et al. (2014) · Nature · doi:10.1038/nature12730 · Cited by 4,558 · see citing works
Self-citationComprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
Meyer, K. D., Saletore, Y., Zumbo, P., Elemento, O., Mason, C. E., & Jaffrey, S. R. (2012) · Cell · doi:10.1016/j.cell.2012.05.003 · Cited by 4,223 · see citing works
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.687 · Cited by 4,106 · see citing works
Self-citationALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.015 · Cited by 3,550 · see citing works
Self-citationN6-methyladenosine Modulates Messenger RNA Translation Efficiency
Wang, X., Zhao, B. S., Roundtree, I. A., Lu, Z., Han, D., Ma, H., Weng, X., Chen, K., Shi, H., & He, C. (2015) · Cell · doi:10.1016/j.cell.2015.05.014 · Cited by 3,483 · see citing works
Self-citationA METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Liu, J., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1432 · Cited by 3,433 · see citing works
Self-citationTranscriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
Hafner, M., Landthaler, M., Burger, L., Khorshid, M., Hausser, J., Berninger, P., Rothballer, A., Ascano, M., Jungkamp, A.-C., Munschauer, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.009 · Cited by 2,873 · see citing works
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
Ping, X.-L., Sun, B.-F., Wang, L., Xiao, W., Yang, X., Wang, W.-J., Adhikari, S., Shi, Y., Lv, Y., Chen, Y.-S., et al. (2014) · Cell Research · doi:10.1038/cr.2014.3 · Cited by 2,375 · see citing works
Self-citationExpansion of the eukaryotic proteome by alternative splicing
Nilsen, T. W., & Graveley, B. R. (2010) · Nature · doi:10.1038/nature08909 · Cited by 2,172 · see citing works
N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions
Liu, N., Dai, Q., Zheng, G., He, C., Parisien, M., & Pan, T. (2015) · Nature · doi:10.1038/nature14234 · Cited by 1,988 · see citing works
5′ UTR m6A Promotes Cap-Independent Translation
Meyer, K. D., Patil, D. P., Zhou, J. L., Zinoviev, A., Skabkin, M. A., Elemento, O., Pestova, T. V., Qian, S., & Jaffrey, S. R. (2015) · Cell · doi:10.1016/j.cell.2015.10.012 · Cited by 1,812 · see citing works
m 6 A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation
Geula, S., Moshitch-Moshkovitz, S., Dominissini, D., Mansour, A. A., Kol, N., Salmon‐Divon, M., Hershkovitz, V., Peer, E., Mor, N., Manor, Y. S., et al. (2015) · Science · doi:10.1126/science.1261417 · Cited by 1,560 · see citing works
HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
Alarcón, C. R., Goodarzi, H., Lee, H., Liu, X., Tavazoie, S., & Tavazoie, S. F. (2015) · Cell · doi:10.1016/j.cell.2015.08.011 · Cited by 1,514 · see citing works
N6-methyladenosine marks primary microRNAs for processing
Alarcón, C. R., Lee, H., Goodarzi, H., Halberg, N., & Tavazoie, S. F. (2015) · Nature · doi:10.1038/nature14281 · Cited by 1,394 · see citing works
The human transcriptome across tissues and individuals
Melé, M., Ferreira, P. G., Reverter, F., DeLuca, D. S., Monlong, J., Sammeth, M., Young, T. R., Goldmann, J. M., Pervouchine, D. D., Sullivan, T. J., et al. (2015) · Science · doi:10.1126/science.aaa0355 · Cited by 1,304 · see citing works
N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
Wang, Y., Li, Y., Toth, J. I., Petroski, M. D., Zhang, Z., & Zhao, J. C. (2014) · Nature Cell Biology · doi:10.1038/ncb2902 · Cited by 1,281 · see citing works
m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells
Batista, P. J., Molinié, B., Wang, J., Qu, K., Zhang, J., Li, L., Bouley, D. M., Lujan, E., Haddad, B., Daneshvar, K., et al. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.09.019 · Cited by 1,276 · see citing works
Dynamic m6A mRNA methylation directs translational control of heat shock response
Zhou, J. L., Wan, J., Gao, X., Zhang, X., Jaffrey, S. R., & Qian, S. (2015) · Nature · doi:10.1038/nature15377 · Cited by 1,228 · see citing works
Schwartz, S., Mumbach, M. R., Jovanović, M., Wang, T., Maciag, K., Bushkin, G. G., Mertins, P., Ter‐Ovanesyan, D., Habib, N., Cacchiarelli, D., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.048 · Cited by 1,213 · see citing works
Zhao, X., Yang, Y., Sun, B.-F., Shi, Y. X., Yang, X., Xiao, W., Hao, Y.-J., Ping, X., Chen, Y., Wang, W., et al. (2014) · Cell Research · doi:10.1038/cr.2014.151 · Cited by 1,186 · see citing works
Self-citationContext-dependent control of alternative splicing by RNA-binding proteins
Fu, X.-D., & Ares, M. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3778 · Cited by 1,044 · see citing works
MODOMICS: a database of RNA modification pathways—2013 update
Machnicka, M. A., Milanowska, K., Oglou, O. O., Purta, E., Kurkowska, M., Olchowik, A., Januszewski, W., Kalinowski, S., Dunin-Horkawicz, S., Rother, K. M., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1007 · Cited by 1,003 · see citing works
RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock
Fustin, J., Doi, M., Yamaguchi, Y., Hayashi, H., Nishimura, S., Yoshida, M., Isagawa, T., Morioka, M. S., Kakeya, H., Manabe, I., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.026 · Cited by 980 · see citing works
Bokar, J. A., Shambaugh, M. E., Polayes, D. A., Matera, A. G., & ROTTMAN, F. M. (1997) · PubMed Central · Cited by 961 · see citing works
The RNA modification database, RNAMDB: 2011 update
Cantara, W. A., Crain, P. F., Rozenski, J., McCloskey, J. A., Harris, K. A., Zhang, X., Vendeix, F. A. P., Fabris, D., & Agris, P. F. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1028 · Cited by 822 · see citing works
Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain
Xu, C., Wang, X., Liu, K., Roundtree, I. A., Tempel, W., Li, Y., Lu, Z., He, C., & Min, J. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1654 · Cited by 710 · see citing works
Self-citationSchwartz, S., Agarwala, S. D., Mumbach, M. R., Jovanović, M., Mertins, P., Shishkin, A., Tabach, Y., Mikkelsen, T. S., Satija, R., Ruvkun, G., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.047 · Cited by 627 · see citing works
Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors
Cáceres, J. F., Stamm, S., Helfman, D. M., & Krainer, A. R. (1994) · Science · doi:10.1126/science.8085156 · Cited by 619 · see citing works
m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency
Chen, T., Hao, Y., Zhang, Y., Li, M., Wang, M., Han, W., Yong-sheng, W., Lv, Y., Hao, J., Wang, L., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.01.016 · Cited by 552 · see citing works
Self-citationHuelga, S. C., Vu, A. Q., Arnold, J. D., Liang, T. Y., Liu, P. P., Yan, B. Y., Donohue, J. P., Shiue, L., Hoon, S., Brenner, S., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.02.001 · Cited by 470 · see citing works
Shepard, P. J., & Hertel, K. J. (2009) · Genome biology · doi:10.1186/gb-2009-10-10-242 · Cited by 433 · see citing works
PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data
Corcoran, D. L., Georgiev, S., Mukherjee, N., Gottwein, E., Skalsky, R. L., Keene, J. D., & Ohler, U. (2011) · Genome biology · doi:10.1186/gb-2011-12-8-r79 · Cited by 339 · see citing works
Genome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing
Pandit, S., Zhou, Y., Shiue, L., Coutinho-Mansfield, G., Li, H., Qiu, J., Huang, J. S., Yeo, G. W.-M., Ares, M., & Fu, X. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.03.001 · Cited by 321 · see citing works
Änkö, M., Müller-McNicoll, M., Brandl, H., Curk, T., Gorup, Č., Henry, I., Ule, J., & Neugebauer, K. M. (2012) · Genome biology · doi:10.1186/gb-2012-13-3-r17 · Cited by 278 · see citing works
A General Definition and Nomenclature for Alternative Splicing Events
Sammeth, M., Foissac, S., & Guigó, R. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000147 · Cited by 261 · see citing works
Hartmann, A. M., Nayler, O., Schwaiger, F., Obermeier, A., & Stamm, S. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.11.3909 · Cited by 195 · see citing works
SR proteins control a complex network of RNA-processing events
Bradley, T., Cook, M. E., & Blanchette, M. (2014) · RNA · doi:10.1261/rna.043893.113 · Cited by 141 · see citing works
Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers
Ibrahim, E. C., Schaal, T. D., Hertel, K. J., Reed, R., & Maniatis, T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500543102 · Cited by 127 · see citing works
The ER Repeat Protein Yt521-B Localizes to a Novel Subnuclear Compartment
Nayler, O., Hartmann, A. M., & Stamm, S. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.5.949 · Cited by 100 · see citing works
Zhou, X., Wu, W., Huang, L., Cheng, Y., Wei, N., Zong, J., Feng, X., Xie, Z., Chen, D., Manley, J. L., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1387 · Cited by 100 · see citing works
Self-citationHan, J., Ding, J., Byeon, C. W., Kim, J., Hertel, K. J., Jeong-Yu, S., & Fu, X. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01117-10 · Cited by 95 · see citing works
Rapid generation of splicing reporters with pSpliceExpress
Kishore, S., Khanna, A., & Stamm, S. (2008) · Gene · doi:10.1016/j.gene.2008.09.021 · Cited by 94 · see citing works
Internal mRNA Methylation Finally Finds Functions
Nilsen, T. W. (2014) · Science · doi:10.1126/science.1249340 · Cited by 78 · see citing works
Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation
Imai, Y., Matsuo, N., Ogawa, S., Tohyama, M., & Takagi, T. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00262-3 · Cited by 71 · see citing works
Buratti, E., Stuani, C., Prato, G. D., & Baralle, F. E. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm444 · Cited by 58 · see citing works
Cytostellin distributes to nuclear regions enriched with splicing factors
Bregman, D. B., Du, L., Yi, L., et al. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.3.387 · Cited by 34 · see citing works
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- Authors
- Xiao, W., Adhikari, S., Dahal, U., Chen, Y.-S., Hao, Y.-J., Sun, B.-F., Sun, H.-Y., Li, A., Ping, X.-L., Lai, W.-Y., Wang, X., Ma, H.-L., Huang, C.-M., Yang, Y., Huang, N., Jiang, G.-B., Wang, H.-L., Zhou, Q., Wang, X.-J., Zhao, Y.-L., & Yang, Y.-G.
- Affiliations
- Chinese Academy of Sciences (CN)
- National Institute of Biological Sciences, Beijing (CN)
- Corresponding author
- Yang, Yun-Gui
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 61
- Issue
- 4
- Pages
- 507-519
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2269054226
- Cited by
- 2,054
- References
- 48
- Citations by year
- 2026: 139 · 2025: 225 · 2024: 281 · 2023: 291 · 2022: 317 · 2021: 255 · 2020: 194 · 2019: 119 · 2018: 127 · 2017: 81 · 2016: 24
- FWCI
- 60.83
- Type
- journal article
- Language
- en
- Update notices
- erratum (2016-03-17)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Research Center for Eco-Environmental Sciences OpenIR (Chinese Academy of Sciences) (submittedVersion, cc-by-nc-sa)
- Funders
- National Natural Science Foundation of China
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- YTHDC1, N6-methyladenosine, m6A reader, pre-mRNA splicing, exon inclusion, SRSF3, SRSF10, nuclear speckles, RNA binding affinity, PAR-CLIP
- MeSH terms
- Serine-Arginine Splicing Factors, RNA Splicing Factors, Adenosine, Binding Sites, Exons, HeLa Cells, Humans, Nerve Tissue Proteins, Repressor Proteins, RNA Splicing, RNA, Messenger, RNA-Binding Proteins, Cell Cycle Proteins
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