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Complex archaea that bridge the gap between prokaryotes and eukaryotes
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The origin of the eukaryotic cell remains one of the most contentious puzzles in modern biology. Recent studies have provided support for the emergence of the eukaryotic host cell from within the archaeal domain of life, but the identity and nature of the putative archaeal ancestor remain a subject of debate. Here we describe the discovery of 'Lokiarchaeota', a novel candidate archaeal phylum, which forms a monophyletic group with eukaryotes in phylogenomic analyses, and whose genomes encode an expanded repertoire of eukaryotic signature proteins that are suggestive of sophisticated membrane remodelling capabilities. Our results provide strong support for hypotheses in which the eukaryotic host evolved from a bona fide archaeon, and demonstrate that many components that underpin eukaryote-specific features were already present in that ancestor. This provided the host with a rich genomic 'starter-kit' to support the increase in the cellular and genomic complexity that is characteristic of eukaryotes.
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“a scenario that has gained recent support from the discovery of the Asgard archaea, which form a monophyletic group with Eukaryotes in phylogenetic analyses and encode various eukaryotic signature proteins (Spang et al. 2015;Zaremba-Niedzwiedzka et al. 2017;Eme et al. 2018).”
From The Emergence of Life (2019) · cites this paper as Spang et al. 2015
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“Furthermore, ATP synthase evolution supports scenarios on eukaryotic origins from an asgardarchaeal host3,4,13,14 and alphaproteobacterial symbiont107,108”
From ATP synthase evolution on a cross-braced dated tree of life (2023) · cites this paper as [3]
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Parks, D. H., Rinke, C., Chuvochina, M., Chaumeil, P.-A., Woodcroft, B. J., Evans, P. N., Hugenholtz, P., & Tyson, G. W. (2017) · Nature Microbiology · doi:10.1038/s41564-017-0012-7 · Cited by 1,882
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Asgard archaea illuminate the origin of eukaryotic cellular complexity
Zaremba-Niedzwiedzka, K., Caceres, E. F., Saw, J. H., Bäckström, D., Juzokaite, L., Vancaester, E., Seitz, K. W., Anantharaman, K., Starnawski, P., Kjeldsen, K. U., et al. (2017) · Nature · doi:10.1038/nature21031 · Cited by 1,226
Self-citation
Metadata
- Authors
- Spang, A., Saw, J. H., Jørgensen, S. L., Zaremba-Niedzwiedzka, K., Martijn, J., Lind, A. E., van Eijk, R., Schleper, C., Guy, L., & Ettema, T. J. G.
- Affiliations
- Uppsala University (SE)
- University of Bergen (NO)
- University of Vienna (AT)
- Corresponding author
- Guy, Lionel
- Ettema, Thijs J. G.
- ORCID
- Venue
- Nature
- Published
- 2015-05
- Volume
- 521
- Issue
- 7551
- Pages
- 173-179
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4444528
- OpenAlex
- W1939911045
- Cited by
- 1,324
- References
- 98
- Citations by year
- 2026: 85 · 2025: 88 · 2024: 118 · 2023: 127 · 2022: 116 · 2021: 125 · 2020: 136 · 2019: 117 · 2018: 118 · 2017: 118 · 2016: 118 · 2015: 54
- FWCI
- 58.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Protist diversity and phylogeny
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- Lokiarchaeota, eukaryotic origin, archaea, membrane remodeling, phylogenomics, cellular complexity
- MeSH terms
- Actins, Archaea, Arctic Regions, Eukaryotic Cells, Actin Cytoskeleton, Molecular Sequence Data, Phylogeny, Prokaryotic Cells, Evolution, Molecular, Proteome, Monomeric GTP-Binding Proteins, Metagenome, Endosomal Sorting Complexes Required for Transport, Eukaryota, Hydrothermal Vents
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