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Complex archaea that bridge the gap between prokaryotes and eukaryotes
Open accessAbstract
The origin of the eukaryotic cell remains one of the most contentious puzzles in modern biology. Recent studies have provided support for the emergence of the eukaryotic host cell from within the archaeal domain of life, but the identity and nature of the putative archaeal ancestor remain a subject of debate. Here we describe the discovery of 'Lokiarchaeota', a novel candidate archaeal phylum, which forms a monophyletic group with eukaryotes in phylogenomic analyses, and whose genomes encode an expanded repertoire of eukaryotic signature proteins that are suggestive of sophisticated membrane remodelling capabilities. Our results provide strong support for hypotheses in which the eukaryotic host evolved from a bona fide archaeon, and demonstrate that many components that underpin eukaryote-specific features were already present in that ancestor. This provided the host with a rich genomic 'starter-kit' to support the increase in the cellular and genomic complexity that is characteristic of eukaryotes.
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“a scenario that has gained recent support from the discovery of the Asgard archaea, which form a monophyletic group with Eukaryotes in phylogenetic analyses and encode various eukaryotic signature proteins (Spang et al. 2015;Zaremba-Niedzwiedzka et al. 2017;Eme et al. 2018).”
From The Emergence of Life (2019) · cites this paper as Spang et al. 2015
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“Furthermore, ATP synthase evolution supports scenarios on eukaryotic origins from an asgardarchaeal host3,4,13,14 and alphaproteobacterial symbiont107,108”
From ATP synthase evolution on a cross-braced dated tree of life (2023) · cites this paper as [3]
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Cites
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability
Katoh, K., & Standley, D. M. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst010 · Cited by 46,209
The SILVA ribosomal RNA gene database project: improved data processing and web-based tools
Quast, C., Pruesse, E., Yilmaz, P., Gerken, J., Schweer, T., Yarza, P., Peplies, J., & Glöckner, F. O. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1219 · Cited by 33,055
RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies
Stamatakis, A. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu033 · Cited by 32,291
SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing
Bankevich, A., Nurk, S., Antipov, D., Gurevich, A. A., Dvorkin, M. V., Kulikov, A. S., Lesin, V. M., Nikolenko, S., Pham, S., Prjibelski, A. D., et al. (2012) · Journal of Computational Biology · doi:10.1089/cmb.2012.0021 · Cited by 26,312
Modern Applied Statistics with S
Venables, W. N., & Ripley, B. D. (2002) · Statisctics and computing/Statistics and computing · doi:10.1007/978-0-387-21706-2 · Cited by 25,941
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 21,098
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 19,549
Research works printed but not linked: 6
- Jorgensen, S. L. et al. Correlating microbial community profiles with geochemical data in highly stratified sediments from the Arctic Mid-Ocean Ridge. Proc. Natl Acad. Sci.. USA 109, E2846–E2855 (2012) · DOI
- Jorgensen, S. L., Thorseth, I. H., Pedersen, R. B., Baumberger, T. & Schleper, C. Quantitative and phylogenetic study of the deep sea archaeal group in sediments of the Arctic Mid-Ocean spreading ridge. Front. Microbiol. 4, 299 (2013) · DOI
- Guy, L., Saw, J. H. & Ettema, T. J. The Archaeal Legacy of Eukaryotes: A Phylogenomic Perspective. Cold Spring Harb. Perspect. Biol.. 6, a016022 (2014) · DOI · Paper page
- Kawai, M. et al. High frequency of phylogenetically diverse reductive dehalogenase-homologous genes in deep subseafloor sedimentary metagenomes. Front. Microbiol. 5, 80 (2014) · DOI
- Ettema, T. J., Lindas, A. C. & Bernander, R. An actin-based cytoskeleton in archaea. Mol. Microbiol.. 80, 1052–1061 (2011) · DOI
- Yutin, N., Wolf, M. Y., Wolf, Y. I. & Koonin, E. V. The origins of phagocytosis and eukaryogenesis. Biol. Direct 4, 9 (2009) · DOI · Paper page
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Viruses and mobile elements as drivers of evolutionary transitions
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Overview of the Cytoskeleton from an Evolutionary PerspectivePreprint
Pollard, T. D., & Goldman, R. D. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a030288 · Cited by 170
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Marine Protists Are Not Just Big Bacteria
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Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments
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Martin, W. F., Tielens, A. G. M., Mentel, M., Garg, S. G., & Gould, S. B. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00008-17 · Cited by 157
DNA Polymerases Divide the Labor of Genome Replication
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Bäckström, D., Yutin, N., Jørgensen, S. L., Dharamshi, J. E., Homa, F., Zaremba-Niedźwiedzka, K., Spang, A., Wolf, Y. I., Koonin, E. V., & Ettema, T. J. G. (2019) · mBio · doi:10.1128/mbio.02497-18 · Cited by 155
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Murray, A., Freudenstein, J., Gribaldo, S., Hatzenpichler, R., Hugenholtz, P., Kämpfer, P., Konstantinidis, K., Lane, C. E., Papke, R., Parks, D., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0733-x · Cited by 132
Self-citationDelmont, T. O., Kiefl, E., Kilinc, O., Esen, Ö. C., Uysal, I., Rappé, M. S., Giovannoni, S. J., & Eren, A. M. (2019) · eLife · doi:10.7554/elife.46497 · Cited by 142
Identification of Oxa1 homologs operating in the eukaryotic endoplasmic reticulum.
Anghel, S. A., McGilvray, P. T., Hegde, R. S., & Keenan, R. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.12.006 · Cited by 150
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Metadata
- Authors
- Spang, A., Saw, J. H., Jørgensen, S. L., Zaremba-Niedzwiedzka, K., Martijn, J., Lind, A. E., van Eijk, R., Schleper, C., Guy, L., & Ettema, T. J. G.
- Affiliations
- Uppsala University (SE)
- University of Bergen (NO)
- University of Vienna (AT)
- Corresponding author
- Guy, Lionel
- Ettema, Thijs J. G.
- ORCID
- Venue
- Nature
- Published
- 2015-05
- Volume
- 521
- Issue
- 7551
- Pages
- 173-179
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4444528
- OpenAlex
- W1939911045
- Cited by
- 1,324
- References
- 98
- Citations by year
- 2026: 85 · 2025: 88 · 2024: 118 · 2023: 127 · 2022: 116 · 2021: 125 · 2020: 136 · 2019: 117 · 2018: 118 · 2017: 118 · 2016: 118 · 2015: 54
- FWCI
- 58.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Protist diversity and phylogeny
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- Lokiarchaeota, eukaryotic origin, archaea, membrane remodeling, phylogenomics, cellular complexity
- MeSH terms
- Actins, Archaea, Arctic Regions, Eukaryotic Cells, Actin Cytoskeleton, Molecular Sequence Data, Phylogeny, Prokaryotic Cells, Evolution, Molecular, Proteome, Monomeric GTP-Binding Proteins, Metagenome, Endosomal Sorting Complexes Required for Transport, Eukaryota, Hydrothermal Vents
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