The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Chromothripsis from DNA damage in micronuclei
Open accessAbstract
Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes. The mechanism for chromothripsis is unknown, but we previously proposed that it could occur through the physical isolation of chromosomes in aberrant nuclear structures called micronuclei. Here, using a combination of live cell imaging and single-cell genome sequencing, we demonstrate that micronucleus formation can indeed generate a spectrum of genomic rearrangements, some of which recapitulate all known features of chromothripsis. These events are restricted to the mis-segregated chromosome and occur within one cell division. We demonstrate that the mechanism for chromothripsis can involve the fragmentation and subsequent reassembly of a single chromatid from a micronucleus. Collectively, these experiments establish a new mutational process of which chromothripsis is one extreme outcome.
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Cites
The landscape of somatic copy-number alteration across human cancers
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Self-citationMassive genomic rearrangement acquired in a single catastrophic event during cancer development
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DNA breaks and chromosome pulverization from errors in mitosis
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Self-citationClonal evolution in breast cancer revealed by single nucleus genome sequencing
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Single-Neuron Sequencing Analysis of L1 Retrotransposition and Somatic Mutation in the Human Brain
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EGFR Variant Heterogeneity in Glioblastoma Resolved through Single-Nucleus Sequencing
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Self-citationThe Architecture and Evolution of Cancer Neochromosomes
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Calibrating genomic and allelic coverage bias in single-cell sequencing
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Cited by
Pan-cancer analysis of whole genomes
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Self-citationcGAS surveillance of micronuclei links genome instability to innate immunity
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Endogenous DNA damage as a source of genomic instability in cancer
Tubbs, A., & Nussenzweig, A. (2017) · Cell · doi:10.1016/j.cell.2017.01.002 · Cited by 1,452
Somatic mutation in cancer and normal cells
Martincorena, I., & Campbell, P. J. (2015) · Science · doi:10.1126/science.aab4082 · Cited by 1,396
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Dou, Z., Ghosh, K., Vizioli, M. G., Zhu, J., Sen, P., Wangensteen, K. J., Simithy, J., Lan, Y., Lin, Y., Zhou, Z., et al. (2017) · Nature · doi:10.1038/nature24050 · Cited by 1,335
Metadata
- Authors
- Zhang, C.-Z., Spektor, A., Cornils, H., Francis, J. M., Jackson, E. K., Liu, S., Meyerson, M., & Pellman, D.
- Venue
- Nature
- Published
- 2015-05-27
- Volume
- 522
- Issue
- 7555
- Pages
- 179-184
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1601755300
- Cited by
- 1,148
- References
- 8
- FWCI
- 67.43
- Type
- journal article
- Language
- en
- Open access
- green
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