The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Brain tumour cells interconnect to a functional and resistant network
Open accessAbstract
Astrocytic brain tumours, including glioblastomas, are incurable neoplasms characterized by diffusely infiltrative growth. Here we show that many tumour cells in astrocytomas extend ultra-long membrane protrusions, and use these distinct tumour microtubes as routes for brain invasion, proliferation, and to interconnect over long distances. The resulting network allows multicellular communication through microtube-associated gap junctions. When damage to the network occurred, tumour microtubes were used for repair. Moreover, the microtube-connected astrocytoma cells, but not those remaining unconnected throughout tumour progression, were protected from cell death inflicted by radiotherapy. The neuronal growth-associated protein 43 was important for microtube formation and function, and drove microtube-dependent tumour cell invasion, proliferation, interconnection, and radioresistance. Oligodendroglial brain tumours were deficient in this mechanism. In summary, astrocytomas can develop functional multicellular network structures. Disconnection of astrocytoma cells by targeting their tumour microtubes emerges as a new principle to reduce the treatment resistance of this disease.
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Cites
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Self-citationCarcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
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Advances in the molecular genetics of gliomas — implications for classification and therapy
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Metadata
- Authors
- Osswald, M., Jung, E., Sahm, F., Solecki, G., Venkataramani, V., Blaes, J., Weil, S., Horstmann, H., Wiestler, B., Syed, M., Huang, L., Ratliff, M., Karimian Jazi, K., Kurz, F. T., Schmenger, T., Lemke, D., Gömmel, M., Pauli, M., Liao, Y., Häring, P., Pusch, S., Herl, V., Steinhäuser, C., Krunic, D., Jarahian, M., Miletic, H., Berghoff, A. S., Griesbeck, O., Kalamakis, G., Garaschuk, O., Preusser, M., Weiss, S., Liu, H., Heiland, S., Platten, M., Huber, P. E., Kuner, T., von Deimling, A., Wick, W., & Winkler, F.
- Venue
- Nature
- Published
- 2015-11-04
- Volume
- 528
- Issue
- 7580
- Pages
- 93-98
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2128130529
- Cited by
- 1,143
- References
- 9
- FWCI
- 30.49
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Brain tumour cells interconnect to a functional and resistant network. https://app.cochat.ai/papers/10.1038/nature16071
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- Osswald, M., Jung, E., Sahm, F., Solecki, G., Venkataramani, V., Blaes, J., Weil, S., Horstmann, H., Wiestler, B., Syed, M., Huang, L., Ratliff, M., Karimian Jazi, K., Kurz, F. T., Schmenger, T., Lemke, D., Gömmel, M., Pauli, M., Liao, Y., . . . Winkler, F. (2015). Brain tumour cells interconnect to a functional and resistant network. Nature. https://doi.org/10.1038/nature16071
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
