The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
SEDS proteins are a widespread family of bacterial cell wall polymerases
Open accessAbstract
Elongation of rod-shaped bacteria is mediated by a dynamic peptidoglycan-synthetizing machinery called the Rod complex. Here we report that, in Bacillus subtilis, this complex is functional in the absence of all known peptidoglycan polymerases. Cells lacking these enzymes survive by inducing an envelope stress response that increases the expression of RodA, a widely conserved core component of the Rod complex. RodA is a member of the SEDS (shape, elongation, division and sporulation) family of proteins, which have essential but ill-defined roles in cell wall biogenesis during growth, division and sporulation. Our genetic and biochemical analyses indicate that SEDS proteins constitute a family of peptidoglycan polymerases. Thus, B. subtilis and probably most bacteria use two distinct classes of polymerase to synthesize their exoskeleton. Our findings indicate that SEDS family proteins are core cell wall synthases of the cell elongation and division machinery, and represent attractive targets for antibiotic development.
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Cites
Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., & Mori, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100050 · Cited by 7,858
Cited by
Regulation of peptidoglycan synthesis and remodelling
Egan, A. J. F., Errington, J., & Vollmer, W. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0366-3 · Cited by 592
Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria
García-Heredia, A., Pohane, A. A., Melzer, E. S., Carr, C. R., Fiolek, T. J., Rundell, S. R., Lim, H. C., Wagner, J. C., Morita, Y. S., Swarts, B. M., et al. (2018) · eLife · doi:10.7554/elife.37243 · Cited by 115
(2020) · doi:10.15252/embj.2019102246 · Cited by 89
Carette, X., Platig, J., Young, D. C., Helmel, M., Young, A. T., Wang, Z., Potluri, L.-P., Moody, C. S., Zeng, J., Prisic, S., et al. (2018) · mBio · doi:10.1128/mbio.02333-17 · Cited by 65
Cell wall-deficient, L-form bacteria in the 21st century: a personal perspective
Errington, J. (2017) · Biochemical Society Transactions · doi:10.1042/bst20160435 · Cited by 52
Metadata
- Authors
- Meeske, A. J., Riley, E. P., Robins, W. P., Uehara, T., Mekalanos, J. J., Kahne, D., Walker, S., Kruse, A. C., Bernhardt, T. G., & Rudner, D. Z.
- Venue
- Nature
- Published
- 2016-08-15
- Volume
- 537
- Issue
- 7622
- Pages
- 634-638
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2517176893
- Cited by
- 491
- References
- 1
- FWCI
- 41.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Meeske, A. J., Riley, E. P., Robins, W. P., Uehara, T., Mekalanos, J. J., Kahne, D., Walker, S., Kruse, A. C., Bernhardt, T. G., & Rudner, D. Z. (2016). SEDS proteins are a widespread family of bacterial cell wall polymerases. Nature. https://doi.org/10.1038/nature19331
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