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Early dissemination seeds metastasis in breast cancer
Open accessAbstract
Accumulating data suggest that metastatic dissemination often occurs early during tumour formation, but the mechanisms of early metastatic spread have not yet been addressed. Here, by studying metastasis in a HER2-driven mouse breast cancer model, we show that progesterone-induced signalling triggers migration of cancer cells from early lesions shortly after HER2 activation, but promotes proliferation in advanced primary tumour cells. The switch from migration to proliferation was regulated by increased HER2 expression and tumour-cell density involving microRNA-mediated progesterone receptor downregulation, and was reversible. Cells from early, low-density lesions displayed more stemness features, migrated more and founded more metastases than cells from dense, advanced tumours. Notably, we found that at least 80% of metastases were derived from early disseminated cancer cells. Karyotypic and phenotypic analysis of human disseminated cancer cells and primary tumours corroborated the relevance of these findings for human metastatic dissemination.
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Emerging Biological Principles of Metastasis
Lambert, A. W., Pattabiraman, D. R., & Weinberg, R. A. (2017) · Cell · doi:10.1016/j.cell.2016.11.037 · Cited by 3,067
Roles of the immune system in cancer: From tumor initiation to metastatic progression
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Epithelial Mesenchymal Transition in Tumor Metastasis
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Metadata
- Authors
- Hosseini, H., Obradović, M. M. S., Hoffmann, M., Harper, K. L., Sosa, M. S., Werner-Klein, M., Nanduri, L. K., Werno, C., Ehrl, C., Maneck, M., Patwary, N., Haunschild, G., Gužvić, M., Reimelt, C., Grauvogl, M., Eichner, N., Weber, F., Hartkopf, A. D., Taran, F.-A., Brucker, S. Y., Fehm, T., Rack, B., Buchholz, S., Spang, R., Meister, G., Aguirre-Ghiso, J. A., & Klein, C. A.
- Venue
- Nature
- Published
- 2016-12-14
- Volume
- 540
- Issue
- 7634
- Pages
- 552-558
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2565834876
- Cited by
- 740
- References
- 5
- FWCI
- 35.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Hosseini, H., Obradović, M. M. S., Hoffmann, M., Harper, K. L., Sosa, M. S., Werner-Klein, M., Nanduri, L. K., Werno, C., Ehrl, C., Maneck, M., Patwary, N., Haunschild, G., Gužvić, M., Reimelt, C., Grauvogl, M., Eichner, N., Weber, F., Hartkopf, A. D., Taran, F.-A., . . . Klein, C. A. (2016). Early dissemination seeds metastasis in breast cancer. Nature. https://doi.org/10.1038/nature20785
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
