The DOI matches its Crossref record; 194 of the 194 references it cites were found in a registry or an index.
Targeting metastatic cancer
Open accessAbstract
Despite recent therapeutic advances in cancer treatment, metastasis remains the principal cause of cancer death. Recent work has uncovered the unique biology of metastasis-initiating cells that results in tumor growth in distant organs, evasion of immune surveillance and co-option of metastatic microenvironments. Here we review recent progress that is enabling therapeutic advances in treating both micro- and macrometastases. Such insights were gained from cancer sequencing, mechanistic studies and clinical trials, including of immunotherapy. These studies reveal both the origins and nature of metastases and identify new opportunities for developing more effective strategies to target metastatic relapse and improve patient outcomes. Increased understanding of the biology of metastases allows improved targeting and outcomes for patients with both micro- and macrometastases.
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Cites
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Cited by
New approaches and procedures for cancer treatment: Current perspectives
Debela, D. T., Muzazu, S. G., Heraro, K. D., Ndalama, M. T., Mesele, B. W., Haile, D. C., Kitui, S. K., & Manyazewal, T. (2021) · SAGE Open Medicine · doi:10.1177/20503121211034366 · Cited by 1,597
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Metastasis-Initiating Cells and Ecosystems
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Self-citation
Metadata
- Authors
- Ganesh, K., & Massagué, J.
- Venue
- Nature Medicine
- Published
- 2021-01
- Volume
- 27
- Issue
- 1
- Pages
- 34-44
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W3118790373
- Cited by
- 1,051
- References
- 194
- FWCI
- 55.52
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
