The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Microenvironmental autophagy promotes tumour growth
Open accessAbstract
As malignant tumours develop, they interact intimately with their microenvironment and can activate autophagy, a catabolic process which provides nutrients during starvation. How tumours regulate autophagy in vivo and whether autophagy affects tumour growth is controversial. Here we demonstrate, using a well characterized Drosophila melanogaster malignant tumour model, that non-cell-autonomous autophagy is induced both in the tumour microenvironment and systemically in distant tissues. Tumour growth can be pharmacologically restrained using autophagy inhibitors, and early-stage tumour growth and invasion are genetically dependent on autophagy within the local tumour microenvironment. Induction of autophagy is mediated by Drosophila tumour necrosis factor and interleukin-6-like signalling from metabolically stressed tumour cells, whereas tumour growth depends on active amino acid transport. We show that dormant growth-impaired tumours from autophagy-deficient animals reactivate tumorous growth when transplanted into autophagy-proficient hosts. We conclude that transformed cells engage surrounding normal cells as active and essential microenvironmental contributors to early tumour growth through nutrient-generating autophagy.
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Cites
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The role for autophagy in cancer
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Autophagy in malignant transformation and cancer progression
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Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
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The Role of Hemocytes in Anopheles gambiae Antiplasmodial Immunity
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Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development
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Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation
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scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
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Autophagy is required for glucose homeostasis and lung tumor maintenance
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Cited by
Biological Functions of Autophagy Genes: A Disease Perspective
Levine, B., & Kroemer, G. (2019) · Cell · doi:10.1016/j.cell.2018.09.048 · Cited by 2,832
Levy, J. M. M., Towers, C. G., & Thorburn, A. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.53 · Cited by 2,526
Autophagy in major human diseases
Klionsky, D. J., Petroni, G., Amaravadi, R. K., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cadwell, K., Cecconi, F., Choi, A. M. K., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2021108863 · Cited by 1,585
Self-citationAutophagy promotes immune evasion of pancreatic cancer by degrading MHC-I
Yamamoto, K., Venida, A., Yano, J., Biancur, D. E., Kakiuchi, M., Gupta, S., Sohn, A. S. W., Mukhopadhyay, S., Lin, E. Y., Parker, S. J., et al. (2020) · Nature · doi:10.1038/s41586-020-2229-5 · Cited by 1,240
Mizushima, N., & Levine, B. (2020) · New England Journal of Medicine · doi:10.1056/nejmra2022774 · Cited by 1,140
Metadata
- Authors
- Katheder, N. S., Khezri, R., O’Farrell, F., Schultz, S. W., Jain, A., Rahman, M. M., Schink, K. O., Theodossiou, T. A., Johansen, T., Juhász, G., Bilder, D., Brech, A., Stenmark, H., & Rusten, T. E.
- Venue
- Nature
- Published
- 2017-01
- Volume
- 541
- Issue
- 7637
- Pages
- 417-420
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2577161328
- Cited by
- 459
- References
- 31
- FWCI
- 32.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Katheder, N. S., Khezri, R., O’Farrell, F., Schultz, S. W., Jain, A., Rahman, M. M., Schink, K. O., Theodossiou, T. A., Johansen, T., Juhász, G., Bilder, D., Brech, A., Stenmark, H., & Rusten, T. E. (2017). Microenvironmental autophagy promotes tumour growth. Nature. https://doi.org/10.1038/nature20815
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