Biological Functions of Autophagy Genes: A Disease Perspective

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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mTOR Signaling in Growth, Metabolism, and Disease

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Autophagy in the Pathogenesis of Disease

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Autophagy: Renovation of Cells and Tissues

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A role for mitochondria in nlrp3 inflammasome activation

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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Autophagy and Viruses: Adversaries or Allies?

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AMPK: guardian of metabolism and mitochondrial homeostasis

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Autophagy regulates lipid metabolism

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mTOR Signaling in Growth, Metabolism, and Disease.

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Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila

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Autophagy and the Integrated Stress Response

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Induction of autophagy and inhibition of tumorigenesis by beclin 1

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Immunogenic cell death in cancer and infectious disease

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Mechanism and medical implications of mammalian autophagy

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

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Current knowledge on exosome biogenesis and release

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

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Self-consumption: the interplay of autophagy and apoptosis

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

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During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

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Signals from the lysosome: a control centre for cellular clearance and energy metabolism

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Network organization of the human autophagy system

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A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

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Autophagy pathway: Cellular and molecular mechanisms

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Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

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Autophagy maintains stemness by preventing senescence

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Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

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JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

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A Unified Nomenclature for Yeast Autophagy-Related Genes

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Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

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Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

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Essential role for Nix in autophagic maturation of erythroid cells

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Spermidine in health and disease

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Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

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Cargo recognition and degradation by selective autophagy

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TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

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Tackling the cancer stem cells — what challenges do they pose?

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Autophagy‐based unconventional secretory pathway for extracellular delivery of IL‐1β

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Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

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Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease)

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Regulation of endoplasmic reticulum turnover by selective autophagy

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Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

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Autophagy maintains the metabolism and function of young and old stem cells

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Ferroptosis: Role of lipid peroxidation, iron and ferritinophagy

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Metabolic control of autophagy

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The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

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Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

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Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor

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Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

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Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesisPreprint

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TFEB at a glance

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Autophagy and Tumor Metabolism

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Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

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Recent insights into the function of autophagy in cancerPreprint

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Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

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Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

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Autophagy and human diseases

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Identification of a candidate therapeutic autophagy-inducing peptide

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Autophagy as a promoter of longevity: insights from model organisms

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Metabolic Control of Longevity

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AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

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Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

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Overexpression of Atg5 in mice activates autophagy and extends lifespan

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p53 status determines the role of autophagy in pancreatic tumour development

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A brief history of autophagy from cell biology to physiology and disease

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Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling

Konno, H., Konno, K., & Barber, G. N. (2013) · Cell · doi:10.1016/j.cell.2013.09.049 · Cited by 676 · see citing works

Autophagy mediates degradation of nuclear lamina

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Mechanisms of Autophagy Initiation

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Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

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Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

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Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

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Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W.-C., et al. (2018) · Nature · doi:10.1038/s41586-018-0162-7 · Cited by 630 · see citing works

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

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Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

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DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy

Nguyen, T. B., Louie, S. M., Daniele, J. R., Tran, Q., Dillin, A., Zoncu, R., Nomura, D. K., & Olzmann, J. A. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.06.003 · Cited by 610 · see citing works

Autosis is a Na ⁺ ,K ⁺ -ATPase–regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia–ischemia

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Autophagy Links Inflammasomes to Atherosclerotic Progression

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ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

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Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

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ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

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Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

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Autophagy balances inflammation in innate immunity

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The Atg5–Atg12 conjugate associates with innate antiviral immune responses

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Autophagy is required for glucose homeostasis and lung tumor maintenance

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Cytosolic lipolysis and lipophagy: two sides of the same coin

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Caloric restriction mimetics enhance anticancer immunosurveillance

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