The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses
Open accessAbstract
Interleukin-17 (IL-17) is a major pro-inflammatory cytokine: it mediates responses to pathogens or tissue damage, and drives autoimmune diseases. Little is known about its role in the nervous system. Here we show that IL-17 has neuromodulator-like properties in Caenorhabditis elegans. IL-17 can act directly on neurons to alter their response properties and contribution to behaviour. Using unbiased genetic screens, we delineate an IL-17 signalling pathway and show that it acts in the RMG hub interneurons. Disrupting IL-17 signalling reduces RMG responsiveness to input from oxygen sensors, and renders sustained escape from 21% oxygen transient and contingent on additional stimuli. Over-activating IL-17 receptors abnormally heightens responses to 21% oxygen in RMG neurons and whole animals. IL-17 deficiency can be bypassed by optogenetic stimulation of RMG. Inducing IL-17 expression in adults can rescue mutant defects within 6 h. These findings reveal a non-immunological role of IL-17 modulating circuit function and behaviour.
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“Previously described non-immune properties of IL-17 included (i) the regulation of social behavior in MIA models1,23, (ii) body temperature24,25, and (iii) neuromodulation in Caenorhabditis elegans2.”
From Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons (2020) · cites this paper as [24]
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Cites
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Schneider, C., O’Leary, C. E., von Moltke, J., Liang, H.-E., Ang, Q. Y., Turnbaugh, P. J., Radhakrishnan, S., Pellizzon, M., Ma, A., & Locksley, R. M. (2018) · Cell · doi:10.1016/j.cell.2018.05.014 · Cited by 478
The Meningeal Lymphatic System: A New Player in Neurophysiology
Da Mesquita, S., Fu, Z., & Kipnis, J. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.022 · Cited by 479
Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons
Alves de Lima, K., Rustenhoven, J., Da Mesquita, S., Wall, M., Salvador, A. F., Smirnov, I., Martelossi Cebinelli, G., Mamuladze, T., Baker, W., Papadopoulos, Z., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0776-4 · Cited by 416
Neuromodulation by the immune system: a focus on cytokines
Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389
Alves de Lima, K., Rustenhoven, J., & Kipnis, J. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-102319-103410 · Cited by 348
Metadata
- Authors
- Chen, C., Itakura, E., Nelson, G. M., Sheng, M., Laurent, P., Fenk, L. A., Butcher, R. A., Hegde, R. S., & de Bono, M.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- University of Florida (US)
- ORCID
- Venue
- Nature
- Published
- 2017-01-18
- Volume
- 542
- Issue
- 7639
- Pages
- 43-48
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5503128
- OpenAlex
- W2576526246
- Cited by
- 127
- References
- 46
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 12 · 2023: 16 · 2022: 11 · 2021: 11 · 2020: 17 · 2019: 12 · 2018: 13 · 2017: 11
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- National Institutes of Health (P40OD010440)
- Japan Society for the Promotion of Science (16H06167, 16H01194)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- IL-17, neuromodulation, Caenorhabditis elegans, oxygen sensing, escape behavior, social aggregation, IL-17 signaling, optogenetic stimulation
- MeSH terms
- Animals, Behavior, Animal, Humans, Interneurons, Oxygen, Sensation, Signal Transduction, Caenorhabditis elegans, Interleukin-17, Caenorhabditis elegans Proteins, Receptors, Interleukin-17, HEK293 Cells
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