Chromatin states define tumour-specific T cell dysfunction and reprogramming

Philip, Mary, Fairchild, Lauren, Sun, Liping, Horste, Ellen L., Camara, Steven, Shakiba, Mojdeh, Scott, Andrew C., Viale, Agnes, Lauer, Peter, Merghoub, Taha, Hellmann, Matthew D., Wolchok, Jedd D., Leslie, Christina S., Schietinger, Andrea·2017·Nature

DOI 10.1038/nature22367

Cited by (934)

Items 201–300 of 934

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Multiomics and spatial mapping characterizes human CD8 + T cell states in cancer
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Disruption of SUV39H1 -Mediated H3K9 Methylation Sustains CAR T-cell Function
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Precursors of exhausted T cells are pre-emptively formed in acute infection
Talyn Chu, Ming Wu, Barbara Höllbacher, Gustavo Pereira de Almeida, Christine Wurmser, Jacqueline Berner, Lara V. Donhauser, Ann-Katrin Gerullis, Siran Lin, J. Diego Cepeda-Mayorga et al. · 2025 · Nature
Ectopic Tcf1 expression instills a stem-like program in exhausted CD8+ T cells to enhance viral and tumor immunity
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CD38: T Cell Immuno-Metabolic Modulator
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Yannick Bulliard, Börje S. Andersson, Mehmet A. Baysal, Jason S. Damiano, Apostolia Maria Tsimberidou · 2023 · Journal of Hematology & Oncology
PD-1 blockade-unresponsive human tumor-infiltrating CD8+ T cells are marked by loss of CD28 expression and rescued by IL-15
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Endogenous CD4+ T Cells Recognize Neoantigens in Lung Cancer Patients, Including Recurrent Oncogenic KRAS and ERBB2 ( Her2 ) Driver Mutations
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Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma
Adam L. Burrack, Ellen J. Spartz, Jackson F. Raynor, Iris Wang, Margaret A Olson, Ingunn M. Stromnes · 2019 · Cell Reports
Decitabine priming increases anti–PD-1 antitumor efficacy by promoting CD8+ progenitor exhausted T cell expansion in tumor models
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Mapping genomic and epigenomic evolution in cancer ecosystems
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Resident memory T cells and cancer
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Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment
Feiya Ma, Jensen Vayalil, Grace Lee, Yuqi Wang, Guangyong Peng · 2021 · Journal for ImmunoTherapy of Cancer
The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells
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IL-2Rα-biased agonist enhances antitumor immunity by invigorating tumor-infiltrating CD25+CD8+ T cells
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Vidit Bhandarkar, Teresa Dinter, Stefani Spranger · 2025 · Science Immunology
CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function
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The diversity of CD8+ T cell dysfunction in cancer and viral infection
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Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion
Elena Battistello, Kimberlee Hixon, Dawn E. Comstock, Clayton K. Collings, Xufeng Chen, Javier Rodriguez-Hernaez, Soobeom Lee, Kasey S. Cervantes, Madeline M. Hinkley, Konstantinos Ntatsoulis et al. · 2023 · Molecular Cell
FOLFOX Chemotherapy Ameliorates CD8 T Lymphocyte Exhaustion and Enhances Checkpoint Blockade Efficacy in Colorectal Cancer
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Epigenetics in modulating immune functions of stromal and immune cells in the tumor microenvironment
Xingyi Pan, Lei Zheng · 2020 · Cellular and Molecular Immunology
Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy
Iris Lodewijk, Sandra P Nunes, Rui Henrique, Cármen Jerónimo, Marta Dueñas, Jesús María Paramio · 2021 · Clinical Epigenetics
Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer
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TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial
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CD8+ T cell exhaustion and its regulatory mechanisms in the tumor microenvironment: key to the success of immunotherapy
Biao Zhang, Jinming Liu, Yuying Mo, Kexin Zhang, Bingqian Huang, Dong Shang · 2024 · Frontiers in Immunology
The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment
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