Leslie, Christina

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Pyonteck, S. M., Akkari, L., Schuhmacher, A. J., Bowman, R. L., Sevenich, L., Quail, D. F., Olson, O. C., Quick, M. L., Huse, J. T., Teijeiro, V., et al. (2013) · Nature Medicine

Immune cells in cancerGlioma Diagnosis and Treatment

Cited by 2,463

Expanded encyclopaedias of DNA elements in the human and mouse genomes

The ENCODE Project Consortium, Abascal, F., Acosta, R., Addleman, N. J., Adrian, J., Afzal, V., Ai, R., Aken, B., Akiyama, J. A., Jammal, O. A., et al. (2020) · Nature

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 2,378

Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites

Betel, D., Koppal, A., Agius, P., Sander, C., & Leslie, C. (2010) · Genome Biology

MicroRNA in disease regulationCancer-related molecular mechanisms research

Cited by 1,592

Chromatin states define tumour-specific T cell dysfunction and reprogramming

Philip, M., Fairchild, L., Sun, L., Horste, E. L., Camara, S., Shakiba, M., Scott, A. C., Viale, A., Lauer, P., Merghoub, T., et al. (2017) · Nature

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 933

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

Peng, M., Yin, N., Chhangawala, S., Xu, K., Leslie, C. S., & Li, M. O. (2016) · Science

Cancer, Hypoxia, and MetabolismT-cell and B-cell Immunology

Cited by 787

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

Khan, A. A., Betel, D., Miller, M. L., Sander, C., Leslie, C. S., & Marks, D. S. (2009) · Nature Biotechnology

MicroRNA in disease regulationRNA Interference and Gene Delivery

Cited by 534

Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification

Samstein, R. M., Arvey, A., Josefowicz, S. Z., Peng, X., Reynolds, A., Sandstrom, R., Neph, S., Sabo, P., Kim, J. M., Liao, W., et al. (2012) · Cell

T-cell and B-cell ImmunologyGenomics and Chromatin Dynamics

Cited by 472

Transcriptome-wide miR-155 Binding Map Reveals Widespread Noncanonical MicroRNA Targeting

Loeb, G. B., Khan, A. A., Canner, D., Hiatt, J. B., Shendure, J., Darnell, R. B., Leslie, C. S., & Rudensky, A. Y. (2012) · Molecular Cell

MicroRNA in disease regulationPlant Molecular Biology Research

Cited by 311

Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota

Akagbosu, B., Tayyebi, Z., Shibu, G., Paucar Iza, Y. A., Deep, D., Parisotto, Y. F., Fisher, L., Pasolli, H. A., Thevin, V., Elmentaite, R., et al. (2022) · Nature

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 273

Artificial intelligence in cancer research, diagnosis and therapy

Elemento, O., Leslie, C., Lundin, J., & Tourassi, G. (2021) · Nature Reviews Cancer

AI in cancer detectionArtificial Intelligence in Healthcare and Education

Cited by 264

An epigenetic barrier sets the timing of human neuronal maturation

Ciceri, G., Baggiolini, A., Cho, H. S., Kshirsagar, M., Benito-Kwiecinski, S., Walsh, R. M., Aromolaran, K. A., Gonzalez-Hernandez, A. J., Munguba, H., Koo, S. Y., et al. (2024) · Nature

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 240

A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance

Feng, Y., van der Veeken, J., Shugay, M., Putintseva, E. V., Osmanbeyoglu, H. U., Dikiy, S., Hoyos, B. E., Moltedo, B., Hemmers, S., Treuting, P., et al. (2015) · Nature

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 157

Induction of Specific MicroRNAs Inhibits Cutaneous Wound Healing

Pastar, I., Khan, A. A., Stojadinovic, O., Lebrun, E. A., Medina, M. C., Brem, H., Kirsner, R. S., Jimenez, J. J., Leslie, C., & Tomic-Canic, M. (2012) · Journal of Biological Chemistry

Wound Healing and TreatmentsMicroRNA in disease regulation

Cited by 132

An encyclopedia of enhancer-gene regulatory interactions in the human genome

Gschwind, A. R., Mualim, K. S., Karbalayghareh, A., Sheth, M. U., Dey, K. K., Jagoda, E., Nurtdinov, R. N., Xi, W., Tan, A. S., Jones, H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory)

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 119

IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation

Park, S.-M., Cho, H., Thornton, A. M., Barlowe, T. S., Chou, T., Chhangawala, S., Fairchild, L., Taggart, J., Chow, A., Schurer, A., et al. (2019) · Cell Stem Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 97

Post-mitotic transcriptional activation and 3D regulatory interactions show locus- and differentiation-specific sensitivity to cohesin depletion

Lee, U., Laguillo-Diego, A., Wong, W., Ni, Z., Cheng, L., Li, J., Pelham-Webb, B., Pertsinidis, A., Leslie, C., & Apostolou, E. (2025) · bioRxiv (Cold Spring Harbor Laboratory)

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 3