The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
Nutrient acquisition strategies of mammalian cells
Open accessAbstract
Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth-factor-induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells.
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“However, there is evidence in rapidly proliferating cells in cancer that serum albumin can be transported into cells and cell organelles, where it can be degraded to its component amino acids acting as building blocks.84, 85, 86, 87, 88”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [87]
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Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Self-citationmTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509
The emerging hallmarks of cancer metabolism
Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926
Self-citationRegulation of cancer cell metabolism
Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744
AMPK: a nutrient and energy sensor that maintains energy homeostasis
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Hypoalbuminemia: Pathogenesis and Clinical Significance
Soeters, P. B., Wolfe, R. R., & Shenkin, A. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1451 · Cited by 1,448
Metabolic regulation of cell growth and proliferation
Zhu, J., & Thompson, C. B. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0123-5 · Cited by 1,154
Self-citationAMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control
González, A., Hall, M. N., Lin, S.-C., & Hardie, D. G. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.015 · Cited by 797
Metabolic landscape of the tumor microenvironment at single cell resolution
Xiao, Z., Dai, Z., & Locasale, J. W. (2019) · Nature Communications · doi:10.1038/s41467-019-11738-0 · Cited by 524
Dierge, E., Debock, E., Guilbaud, C., Corbet, C., Mignolet, É., Mignard, L., Bastien, E., Dessy, C., Larondelle, Y., & Féron, O. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.05.016 · Cited by 505
Metadata
- Authors
- Palm, W., & Thompson, C. B.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Thompson, Craig B.
- Venue
- Nature
- Published
- 2017-06
- Volume
- 546
- Issue
- 7657
- Pages
- 234-242
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5541675
- OpenAlex
- W2624068238
- Cited by
- 388
- References
- 111
- Citations by year
- 2026: 25 · 2025: 37 · 2024: 34 · 2023: 36 · 2022: 58 · 2021: 53 · 2020: 55 · 2019: 39 · 2018: 40 · 2017: 11
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Genentech Foundation
- Hope Funds for Cancer Research
- Foundation of Hope for Research and Treatment of Mental Illness
- National Cancer Institute (P01CA104838, R01CA201318, P30CA008748)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- nutrient acquisition, nutrient sensing, transmembrane transporters, growth factors, oncogenes, tumour suppressor, cancer metabolism, metabolic flexibility, starvation survival, cell proliferation, nutrient homeostasis
- MeSH terms
- Animals, Cells, Endocytosis, Glucose, Glutamine, Lysosomes, Neoplasms, Pinocytosis, Proteins, Intercellular Signaling Peptides and Proteins, Cell Proliferation, Tumor Microenvironment
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