AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

mTOR Signaling in Growth, Metabolism, and Disease

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

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A mammalian protein targeted by G1-arresting rapamycin–receptor complex

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

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Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

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On the origin of mitosing cells

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H ⁺ -ATPase

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Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

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Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

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A central integrator of transcription networks in plant stress and energy signalling

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RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

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The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

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Sestrin2 is a leucine sensor for the mTORC1 pathway

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The energetics of genome complexity.

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Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

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AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

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A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

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mTOR kinase structure, mechanism and regulation

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mTOR as a central hub of nutrient signalling and cell growth

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LKB1 modulates lung cancer differentiation and metastasis

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Making new contacts: the mTOR network in metabolism and signalling crosstalk

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AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

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The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases

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Rheb Binds and Regulates the mTOR Kinase

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Rapamycin passes the torch: a new generation of mTOR inhibitors

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Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

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A hierarchy of ATP-consuming processes in mammalian cells

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Structure of mammalian AMPK and its regulation by ADP

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Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

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The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

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Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

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AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

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The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

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The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor

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Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

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Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

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Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise

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mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

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Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

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LKB1-Dependent Signaling Pathways

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The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1

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Differential regulation of mTORC1 by leucine and glutamine

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CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

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The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

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Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1

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Glutaminolysis Activates Rag-mTORC1 Signaling

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Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

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5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle.

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Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle

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A Yeast Gene That Is Essential for Release from Glucose Repression Encodes a Protein Kinase

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Nutrient sensing and TOR signaling in yeast and mammals

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The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif

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Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

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SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

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AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

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The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in <i>C. elegans</i>

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mTORC1 signaling and the metabolic control of cell growth

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The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

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Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.

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TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

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AMPK is a direct adenylate charge-regulated protein kinase

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Convergent energy and stress signaling

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A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

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The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

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SNF1/AMPK pathways in yeast

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