The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
RETRACTED ARTICLE: Crystal structures of agonist-bound human cannabinoid receptor CB1
Open accessAbstract
The cannabinoid receptor 1 (CB1) is the principal target of the psychoactive constituent of marijuana, the partial agonist Δ9-tetrahydrocannabinol (Δ9-THC). Here we report two agonist-bound crystal structures of human CB1 in complex with a tetrahydrocannabinol (AM11542) and a hexahydrocannabinol (AM841) at 2.80 Å and 2.95 Å resolution, respectively. The two CB1–agonist complexes reveal important conformational changes in the overall structure, relative to the antagonist-bound state, including a 53% reduction in the volume of the ligand-binding pocket and an increase in the surface area of the G-protein-binding region. In addition, a ‘twin toggle switch’ of Phe2003.36 and Trp3566.48 (superscripts denote Ballesteros–Weinstein numbering) is experimentally observed and appears to be essential for receptor activation. The structures reveal important insights into the activation mechanism of CB1 and provide a molecular basis for predicting the binding modes of Δ9-THC, and endogenous and synthetic cannabinoids. The plasticity of the binding pocket of CB1 seems to be a common feature among certain class A G-protein-coupled receptors. These findings should inspire the design of chemically diverse ligands with distinct pharmacological properties.
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Phaser crystallographic software
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Crystal structure of the β2 adrenergic receptor–Gs protein complex
Rasmussen, S. G. F., DeVree, B. T., Zou, Y., Kruse, A. C., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., et al. (2011) · Nature · doi:10.1038/nature10361 · Cited by 3,009
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Early phytocannabinoid chemistry to endocannabinoids and beyond
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Pitsillou, E., Bresnehan, S. M., Kagarakis, E. A., Wijoyo, S. J., Liang, J., Hung, A., & Karagiannis, T. C. (2020) · Molecular Biology Reports · doi:10.1007/s11033-019-05129-3 · Cited by 206
Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years
Maccarrone, M., Di Marzo, V., Gertsch, J., Grether, U., Howlett, A. C., Hua, T., Makriyannis, A., Piomelli, D., Ueda, N., & van der Stelt, M. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000600 · Cited by 183
Self-citationSpanagel, R. (2020) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2020.22.3/rspanagel · Cited by 127
Why Are the Majority of Active Compounds in the CNS Domain Natural Products? A Critical Analysis
Bharate, S. S., Mignani, S., & Vishwakarma, R. A. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01922 · Cited by 102
Metadata
- Authors
- Hua, T., Vemuri, K., Nikas, S. P., Laprairie, R. B., Wu, Y., Qu, L., Pu, M., Korde, A., Jiang, S., Ho, J.-H., Han, G. W., Ding, K., Li, X., Liu, H., Hanson, M. A., Zhao, S., Bohn, L. M., Makriyannis, A., Stevens, R. C., & Liu, Z.-J.
- Venue
- Nature
- Published
- 2017-07-05
- Volume
- 547
- Issue
- 7664
- Pages
- 468-471
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2729726531
- Cited by
- 479
- References
- 7
- FWCI
- 20.96
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- green
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- Hua, T., Vemuri, K., Nikas, S. P., Laprairie, R. B., Wu, Y., Qu, L., Pu, M., Korde, A., Jiang, S., Ho, J.-H., Han, G. W., Ding, K., Li, X., Liu, H., Hanson, M. A., Zhao, S., Bohn, L. M., Makriyannis, A., Stevens, R. C., & Liu, Z.-J. (2017). RETRACTED ARTICLE: Crystal structures of agonist-bound human cannabinoid receptor CB1. Nature. https://doi.org/10.1038/nature23272
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