Early phytocannabinoid chemistry to endocannabinoids and beyond

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633 · see citing works

Molecular characterization of a peripheral receptor for cannabinoids

Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092 · see citing works

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011 · see citing works

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913 · see citing works

Determination and characterization of a cannabinoid receptor in rat brain

Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443 · see citing works

Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

Gaoni, Y., & Mechoulam, R. (1964) · Journal of the American Chemical Society · doi:10.1021/ja01062a046 · Cited by 2,389 · see citing works

2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., & Waku, K. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2437 · Cited by 2,196 · see citing works

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142 · see citing works

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., & Gilula, N. B. (1996) · Nature · doi:10.1038/384083a0 · Cited by 2,125 · see citing works

The diverse CB 1 and CB 2 receptor pharmacology of three plant cannabinoids: Δ 9 ‐tetrahydrocannabinol, cannabidiol and Δ 9 ‐tetrahydrocannabivarin

Pertwee, R. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707442 · Cited by 1,953 · see citing works

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

Rinaldi, M. L., Barth, F., Héaulme, M., Shire, D. J., Calandra, B., Congy, C., Martinez, S., Maruani, J., Neliat, G., Caput, D., et al. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00773-x · Cited by 1,751 · see citing works

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

Pertwee, R. G., Howlett, A. C., Abood, M. E., Alexander, S. P. H., Marzo, V. D., Elphick, M. R., Greasley, P. J., Hansen, H. S., Kunos, G., Mackie, K., et al. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.003004 · Cited by 1,610 · see citing works

Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses

Wilson, R. I., & Nicoll, R. A. (2001) · Nature · doi:10.1038/35069076 · Cited by 1,607 · see citing works

Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study

Gaal, L. F. V., Rissanen, A., Scheen, A. J., Ziegler, O., & Rössner, S. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66374-x · Cited by 1,500 · see citing works

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia

Leweke, F. M., Piomelli, D., Pahlisch, F., Muhl, D., Gerth, C. W., Hoyer, C., Klosterkötter, J., Hellmich, M., & Koethe, D. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.15 · Cited by 1,059 · see citing works

Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

Bisogno, T., Howell, F., Williams, G., Minassi, A., Cascio, M. G., Ligresti, A., Matias, I., Schiano-Moriello, A., Paul, P., Williams, E.-J., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200305129 · Cited by 1,039 · see citing works

Effects of cannabinoids and cannabinoid‐enriched <i>Cannabis</i> extracts on TRP channels and endocannabinoid metabolic enzymes

De Petrocellis, L., Ligresti, A., Moriello, A. S., Allarà, M., Bisogno, T., Petrosino, S., Stott, C. G., & Di Marzo, V. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01166.x · Cited by 946 · see citing works

Cannabinoid pharmacology: the first 66 years

Pertwee, R. G. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706406 · Cited by 783 · see citing works

The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)

Smart, D., Gunthorpe, M. J., Jerman, J. C., Nasir, S., Gray, J., Muir, A. I., Chambers, J. K., Randall, A. D., & Davis, J. B. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703050 · Cited by 775 · see citing works

Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study

Scheen, A. J., Finer, N., Hollander, P. A., Jensen, M. D., & Gaal, L. F. V. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69571-8 · Cited by 729 · see citing works

SR 144528, the First Potent and Selective Antagonist of the CB2 Cannabinoid Receptor

Rinaldi, M. L., Barth, F., Millan, J., Derocq, J., Casellas, P., Congy, C., Oustric, D., Sarran, M., Bouaboula, M., Calandra, B., et al. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37266-0 · Cited by 708 · see citing works

Multiple Functions of Endocannabinoid Signaling in the Brain

Katona, I., & Freund, T. F. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150420 · Cited by 630 · see citing works

HU-308: A specific agonist for CB 2 , a peripheral cannabinoid receptor

Hanus, L. O., Breuer, A., Tchilibon, S., Shiloah, S., Goldenberg, D., Horowitz, M., Pertwee, R. G., Ross, R. A., Mechoulam, R., & Fride, E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14228 · Cited by 574 · see citing works

Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients

Cunha, J. M., Carlini, E. A., Pereira, A. E., Ramos, O. L., Pimentel, C., Gagliardi, R. J., Sanvito, W. L., Lander, N., & Mechoulam, R. (2008) · Pharmacology · doi:10.1159/000137430 · Cited by 570 · see citing works

Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1

Bouaboula, M., Poinot‐Chazel, C., Bourrié, B., Canat, X., Calandra, B., Rinaldi, M. L., Fur, G. L., & Casellas, P. (1995) · Biochemical Journal · doi:10.1042/bj3120637 · Cited by 542 · see citing works

Pharmacology of Cannabinoid Receptor Ligands

Pertwee, R. G. (1999) · Current Medicinal Chemistry · doi:10.2174/0929867306666220401124036 · Cited by 530 · see citing works

Health aspects of cannabis

Hollister, L. E. (1987) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(87)90030-4 · Cited by 500 · see citing works

Hashish—I

Mechoulam, R., & Shvo, Y. (1963) · Tetrahedron · doi:10.1016/0040-4020(63)85022-x · Cited by 486 · see citing works

Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.

Howlett, A. C., Qualy, J. M., & Khachatrian, L. (1986) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10219-8 · Cited by 470 · see citing works

A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1

Bouaboula, M., Perachon, S., Milligan, L., Canat, X., Rinaldi, M. L., Portier, M., Barth, F., Calandra, B., Pecceu, F., Lupker, J. H., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.35.22330 · Cited by 461 · see citing works

Emerging strategies for exploiting cannabinoid receptor agonists as medicines

Pertwee, R. G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00048.x · Cited by 436 · see citing works

Is lipid signaling through cannabinoid 2 receptors part of a protective system?

Pacher, P., & Mechoulam, R. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.01.001 · Cited by 420 · see citing works

Pharmacokinetics and metabolism of delta 1-tetrahydrocannabinol and other cannabinoids with emphasis on man.

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Effect of Rimonabant on Progression of Atherosclerosis in Patients With Abdominal Obesity and Coronary Artery Disease

Nissen, S. E., Nicholls, S. J., Wolski, K., Rodés‐Cabau, J., Cannon, C. P., Deanfield, J. E., Després, J., Kastelein, J. J. P., Steinhubl, S. R., Kapadia, S. R., et al. (2008) · JAMA · doi:10.1001/jama.299.13.1547 · Cited by 406 · see citing works

Modulating the endocannabinoid system in human health and disease – successes and failures

Pacher, P., & Kunos, G. (2013) · FEBS Journal · doi:10.1111/febs.12260 · Cited by 406 · see citing works

Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes.

Howlett, A. C., & Fleming, R. M. (1984) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)15066-9 · Cited by 376 · see citing works

Cannabinoid CB2 receptor: a new target for controlling neural cell survival?

Fernández‐Ruíz, J., Romero, J., Velasco, G., Tolón, R. M., Ramos, J. A., & Guzmán, M. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.11.001 · Cited by 362 · see citing works

Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy

Porter, B. E., & Jacobson, C. A. (2013) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2013.08.037 · Cited by 359 · see citing works

In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity.

Compton, D. M., Aceto, M. D. G., Lowe, J. A., III, & Martin, B. R. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12911-x · Cited by 357 · see citing works

Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

Tam, J., Çınar, R., Liu, J., Godlewski, G., Wesley, D., Jourdan, T., Szanda, G., Mukhopadhyay, B., Chedester, L., Liow, J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.002 · Cited by 356 · see citing works

Receptors and Channels Targeted by Synthetic Cannabinoid Receptor Agonists and Antagonists

Pertwee, R. G. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710790980050 · Cited by 335 · see citing works

Chemical Probes of Endocannabinoid Metabolism

Blankman, J. L., & Cravatt, B. F. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.006387 · Cited by 327 · see citing works

Cannabinoids as Therapeutic Agents

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CB1 Cannabinoid Receptors and their Associated Proteins

Howlett, A. C., Blume, L. C., & Dalton, G. D. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710790980023 · Cited by 296 · see citing works

Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. I. Inhibition of adenylate cyclase mediated by alpha receptors.

Sabol, S. L., & Nirenberg, M. W. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37743-8 · Cited by 289 · see citing works

Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation

Galve‐Roperh, I., Chiurchiù, V., Díaz-Alonso, J., Bari, M., Guzmán, M., & Maccarrone, M. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.05.004 · Cited by 280 · see citing works

Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression

Moreira, F. A., Grieb, M., & Lutz, B. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.09.003 · Cited by 272 · see citing works

Cannabinoid CB 2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation

Wright, K. L., Duncan, M., & Sharkey, K. A. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707486 · Cited by 269 · see citing works

Cannabinoid inhibition of adenylate cyclase. Biochemistry of the response in neuroblastoma cell membranes.

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Δ9‐Tetrahydrocannabinol andN‐arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC‐1B cells

McHugh, D., Page, J., Dunn, E., & Bradshaw, H. B. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01497.x · Cited by 251 · see citing works

Hemopressin is an inverse agonist of CB 1 cannabinoid receptors

Heimann, A. S., Gomes, I., Dale, C. S., Pagano, R. L., Gupta, A., Souza, L. L., Luchessi, A. D., de Castro, L. M., Giorgi, R., Rioli, V., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706980105 · Cited by 242 · see citing works

Health aspects of cannabis.

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Peripheral gating of pain signals by endogenous lipid mediators

Piomelli, D., & Sasso, O. (2014) · Nature Neuroscience · doi:10.1038/nn.3612 · Cited by 236 · see citing works

LY320135, a Novel Cannabinoid CB1 Receptor Antagonist, Unmasks Coupling of the CB1 Receptor to Stimulation of cAMP Accumulation

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Handbook of Cannabis

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Targeting CB2 receptors and the endocannabinoid system for the treatment of pain

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Enantiomeric cannabinoids: stereospecificity of psychotropic activity

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CB2receptor‐mediated migration of immune cells: it can go either way

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The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids

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Preliminary, Open-Label, Pilot Study of Add-On Oral Δ9-Tetrahydrocannabinol in Chronic Post-Traumatic Stress Disorder

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The ring test: a quantitative method for assessing the ‘cataleptic’ effect of cannabis in mice

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N -arachidonoyl l -serine, an endocannabinoid-like brain constituent with vasodilatory properties

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A fatty gut feeling

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Recent advances in the chemistry and biochemistry of cannabis

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The central neuropharmcology of psychotropic cannabinoids

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Anti-inflammatory lipoxin A 4 is an endogenous allosteric enhancer of CB 1 cannabinoid receptor

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Stimulation of Cannabinoid Receptor CB1 Induces krox-24 Expression in Human Astrocytoma Cells

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Synthesis and Pharmacology of a Very Potent Cannabinoid Lacking a Phenolic Hydroxyl with High Affinity for the CB2 Receptor

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Physical withdrawal in rats tolerant to Δ9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist

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Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB1 Receptors

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Cannabinoid pharmacology.

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AM630, a competitive cannabinoid receptor antagonist

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Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds

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Nucleotide sequence of a human cannabinoid receptor cDNA

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CB1 antagonists for obesity—what lessons have we learned from rimonabant?

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Structure-activity relationships for cannabinoid receptor-binding and analgesic activity: studies of bicyclic cannabinoid analogs.

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Characterization and distribution of binding sites for [3H]-SR 141716A, a selective brain (CB1) cannabinoid receptor antagonist, in rodent brain

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Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A

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Role of CB2 receptors in neuroprotective effects of cannabinoids

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Stereochemical effects of 11-OH-Δ8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor

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Biology and therapeutic potential of cannabinoid CB2receptor inverse agonists

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Identification of endogenous acyl amino acids based on a targeted lipidomics approach

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Cannabinoid CB1receptor‐interacting proteins: novel targets for central nervous system drug discovery?

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Neuropsychiatric Adverse Effects of Centrally Acting Antiobesity Drugs

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A new cannabinoid CB2 receptor agonist HU‐910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury

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A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists

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Regulation of adenylate cyclase activity mediated by muscarinic acetylcholine receptors.

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Epigenetic control of skin differentiation genes by phytocannabinoids

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Endocannabinoids and Retrograde Modulation of Synaptic Transmission

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