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Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
Open accessAbstract
Group 2 innate lymphoid cells (ILC2s) regulate inflammation, tissue repair and metabolic homeostasis, and are activated by host-derived cytokines and alarmins. Discrete subsets of immune cells integrate nervous system cues, but it remains unclear whether neuron-derived signals control ILC2s. Here we show that neuromedin U (NMU) in mice is a fast and potent regulator of type 2 innate immunity in the context of a functional neuron-ILC2 unit. We found that ILC2s selectively express neuromedin U receptor 1 (Nmur1), and mucosal neurons express NMU. Cell-autonomous activation of ILC2s with NMU resulted in immediate and strong NMUR1-dependent production of innate inflammatory and tissue repair cytokines. NMU controls ILC2s downstream of extracellular signal-regulated kinase and calcium-influx-dependent activation of both calcineurin and nuclear factor of activated T cells (NFAT). NMU treatment in vivo resulted in immediate protective type 2 responses. Accordingly, ILC2-autonomous ablation of Nmur1 led to impaired type 2 responses and poor control of worm infection. Notably, mucosal neurons were found adjacent to ILC2s, and these neurons directly sensed worm products and alarmins to induce NMU and to control innate type 2 cytokines. Our work reveals that neuron-ILC2 cell units confer immediate tissue protection through coordinated neuroimmune sensory responses.
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“For example, activation of type 2 innate lymphoid cells (ILC2) in the gut mucosa is regulated by neuronally-derived peptides, with neuromedin U initiating102, and α-calcitonin gene-related peptide (αCGRP) antagonizing, type 2 immunity103.”
From Central regulation of stress-evoked peripheral immune responses (2023) · cites this paper as [102]
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limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
affy—analysis of Affymetrix GeneChip data at the probe level
Gautier, L., Cope, L., Bolstad, B. M., & Irizarry, R. A. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg405 · Cited by 5,221
Orchestrating high-throughput genomic analysis with Bioconductor
Huber, W. K., Carey, V. J., Gentleman, R. C., Anders, S., Carlson, M. R. J., Carvalho, B. S., Bravo, H. C., Davis, S. R., Gatto, L., Girke, T., et al. (2015) · Nature Methods · doi:10.1038/nmeth.3252 · Cited by 3,614
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
Shinkai, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90029-c · Cited by 2,651
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M. G., Langford, T. K. A., Bucks, C. M., Kane, C. M., Fallon, P. G., Pannell, R., et al. (2010) · Nature · doi:10.1038/nature08900 · Cited by 2,079
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Monticelli, L. A., Sonnenberg, G. F., Abt, M. C., Alenghat, T., Ziegler, C. G. K., Doering, T. A., Angelosanto, J., Laidlaw, B. J., Yang, C. Y., Sathaliyawala, T., et al. (2011) · Nature Immunology · doi:10.1038/ni.2131 · Cited by 1,327
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Monticelli (2011) · PubMed · doi:10.1031/ni.2131 · Cited by 1,286
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Ren, W., Hua, M., Cao, F., & Zeng, W. (2023) · Advanced Science · doi:10.1002/advs.202306128 · Cited by 32
Jha, M. K., Han, Y., Liu, Z., Hara, Y., Langohr, I. M., Morel, C., Maloney, C., Piepenhagen, P. A., Xing, H., Bodea, C. A., et al. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.05.011 · Cited by 32
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Self-citationHirose, S., Shafiei-Jahani, P., Wang, S., Jaggi, U., Tormanen, K., Yu, J., Kato, M., Akbari, O., & Ghiasi, H. (2020) · iScience · doi:10.1016/j.isci.2020.101549 · Cited by 32
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Yeung, S. S.-H., Ho, J. Y. S., & Chang, R. C. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00660-5 · Cited by 32
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McGinty, J. W., & von Moltke, J. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2019.11.005 · Cited by 25
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Xiao, Q., Han, X., Liu, G., Zhou, D., Zhang, L., He, J., Xu, H., Zhou, P., Yang, Q., Chen, J., et al. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00475-7 · Cited by 25
Yang, Q., Li, Y., Li, B., & Gong, Y. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.105956 · Cited by 26
Sun, P., Li, H., Xu, Q., Zhang, Z., Chen, J., Shen, Y., Qi, X., Lu, J., Tan, Y., Wang, X., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.16012 · Cited by 26
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Feng, X., Andersson, T., Flüchter, P., Gschwend, J., Berest, I., Muff, J. L., Lechner, A., Gondrand, A., Westermann, P., Brander, N., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02104-y · Cited by 29
Sun, N., Cao, L.-S., Xia, W.-Y., Wang, J., & Wu, Q. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03500-9 · Cited by 25
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Meloun, A., & León, B. (2023) · Frontiers in Allergy · doi:10.3389/falgy.2023.1265049 · Cited by 23
Uddin, J., Yano, H., Parkhurst, C. N., Zhang, W., Ahmed, A., de Godoy, V. R., Wei, Q., Panchakshari, R. A., Henninot, A., Dasgupta, S., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02243-2 · Cited by 23
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McSorley, H. J., Chayé, M. A. M., & Smits, H. H. (2018) · Parasite Immunology · doi:10.1111/pim.12574 · Cited by 26
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Nagashima, H., Shayne, J., Jiang, K., Petermann, F., Pękowska, A., Kanno, Y., & O’Shea, J. J. (2024) · Nature Immunology · doi:10.1038/s41590-024-02007-4 · Cited by 23
Aguilar, D., Zhu, F., Millet, A., Millet, N., Germano, P. M., Pisegna, J. R., Akbari, O., Doherty, T. A., Swidergall, M., & Jendzjowsky, N. G. (2024) · Nature Communications · doi:10.1038/s41467-024-53269-3 · Cited by 23
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Kerscher, B., Barlow, J. L., Rana, B. M. J., Jolin, H. E., Gogoi, M., Bartholomew, M. A., Jhamb, D., Pandey, A., Tough, D. F., van Oosterhout, A. J. M., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00678 · Cited by 22
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Pasquale, C. D., Campana, S., Bonaccorsi, I., Carrega, P., & Ferlazzo, G. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100963 · Cited by 22
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Bala, N., McGurk, A. I., Zilch, T. J., Rup, A. N., Carter, E. M., Leddon, S. A., & Fowell, D. J. (2021) · Immunological Reviews · doi:10.1111/imr.13047 · Cited by 21
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Liu, G., Chen, Y., Wang, Y., Deng, X., Xiao, Q., Zhang, L., Xu, H., Han, X. D., Lei, A., He, J., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20211001 · Cited by 23
Lee, M. W., Lee, E. Y., Ferguson, A. L., & Wong, G. C. L. (2018) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2018.11.003 · Cited by 22
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Seillet, C., & Jacquelot, N. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0217-1 · Cited by 22
Trained innate lymphoid cells in allergic diseases
Ebihara, T., Tatematsu, M., Fuchimukai, A., Yamada, T., Yamagata, K., Takasuga, S., & Yamada, T. (2020) · Allergology International · doi:10.1016/j.alit.2020.11.007 · Cited by 22
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Neuronal regulation of intestinal immune functions in health and disease
Fornai, M., van den Wijngaard, R. M., Antonioli, L., Pellegrini, C., Blandizzi, C., & de Jonge, W. J. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13406 · Cited by 22
Regulation of Human Innate Lymphoid Cells in the Context of Mucosal Inflammation
Schulz-Kuhnt, A., Wirtz, S. J., Neurath, M. F., & Atreya, I. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01062 · Cited by 21
Akama, Y., Park, E. J., Satoh‐Takayama, N., Gaowa, A., Ito, A., Kawamoto, E., Darkwah, S. O., Appiah, M. G., Myint, P. K., Ohno, H., et al. (2020) · Shock · doi:10.1097/shk.0000000000001647 · Cited by 21
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Qin, M., Fang, Y., Zheng, Q., Peng, M., Wang, L., Sang, X., & Cao, G. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02096-y · Cited by 20
Wan, Y., Zhang, J., Fang, C., Chen, J., Li, J., Li, J., Wu, C., & Wang, Y. (2017) · Peptides · doi:10.1016/j.peptides.2017.12.022 · Cited by 20
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Yamada, T., Tatematsu, M., Takasuga, S., Fuchimukai, A., Yamagata, K., Seki, S., Kuba, K., Yoshida, H., Taniuchi, I., Bernhardt, G., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20222005 · Cited by 20
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Wang, S., Hu, D., Wang, C., Tang, X., Du, M., Gu, X., Suo, J., Hu, M., Fang, R., Zhu, X., et al. (2019) · Parasites & Vectors · doi:10.1186/s13071-019-3441-8 · Cited by 21
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Basso, L., Serhan, N., Tauber, M., & Gaudenzio, N. (2019) · European Journal of Immunology · doi:10.1002/eji.201848027 · Cited by 25
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Wu, K., Wang, X., Keeler, S. P., Gerovac, B. J., Agapov, E. V., Byers, D. E., Gilfillan, S., Colonna, M., Zhang, Y., & Holtzman, M. J. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000181 · Cited by 19
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Wang, R., Wang, Y., Harris, D. C. H., & Cao, Q. (2020) · Kidney International · doi:10.1016/j.kint.2020.11.023 · Cited by 20
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Hirose, S., Wang, S., Tormanen, K., Wang, Y., Tang, J., Akbari, O., & Ghiasi, H. (2019) · Journal of Virology · doi:10.1128/jvi.00523-19 · Cited by 19
Akama, Y., Satoh‐Takayama, N., Kawamoto, E., Ito, A., Gaowa, A., Park, E. J., Imai, H., & Shimaoka, M. (2020) · Diagnostics · doi:10.3390/diagnostics10100808 · Cited by 21
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Metadata
- Authors
- Cardoso, V., Chesné, J., Ribeiro, H., García-Cassani, B., Carvalho, T., Bouchery, T., Shah, K., Barbosa-Morais, N. L., Harris, N., & Veiga-Fernandes, H.
- Affiliations
- University of Lisbon (PT)
- École Polytechnique Fédérale de Lausanne (CH)
- ORCID
- Venue
- Nature
- Published
- 2017-09-06
- Volume
- 549
- Issue
- 7671
- Pages
- 277-281
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5714273
- OpenAlex
- W2750992365
- Cited by
- 592
- References
- 44
- Citations by year
- 2026: 53 · 2025: 69 · 2024: 50 · 2023: 46 · 2022: 79 · 2021: 70 · 2020: 70 · 2019: 79 · 2018: 67 · 2017: 9
- FWCI
- 27.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Funders
- Crohn's and Colitis Foundation (313089)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (156517, 310030)
- Medical Research Council (MR/R024812/1)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Keywords
- ILC2, neuromedin U, enteric neurons, neuroimmune interactions, Nippostrongylus brasiliensis, Th2 immune response, tissue repair, calcineurin, NFAT, ERK signaling, alarmins, gastrointestinal nematode infection, mucosal immunity
- MeSH terms
- Animals, Calcium, Female, Immunity, Innate, Lymphocytes, Male, Mice, Inbred C57BL, Neurons, Neuropeptides, Nippostrongylus, Cytokines, Strongylida Infections, Receptors, Neurotransmitter, Calcineurin, MAP Kinase Signaling System, NFATC Transcription Factors, Mice
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