The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Commensal bacteria make GPCR ligands that mimic human signalling molecules
Open accessAbstract
Commensal bacteria are believed to have important roles in human health. The mechanisms by which they affect mammalian physiology remain poorly understood, but bacterial metabolites are likely to be key components of host interactions. Here we use bioinformatics and synthetic biology to mine the human microbiota for N-acyl amides that interact with G-protein-coupled receptors (GPCRs). We found that N-acyl amide synthase genes are enriched in gastrointestinal bacteria and the lipids that they encode interact with GPCRs that regulate gastrointestinal tract physiology. Mouse and cell-based models demonstrate that commensal GPR119 agonists regulate metabolic hormones and glucose homeostasis as efficiently as human ligands, although future studies are needed to define their potential physiological role in humans. Our results suggest that chemical mimicry of eukaryotic signalling molecules may be common among commensal bacteria and that manipulation of microbiota genes encoding metabolites that elicit host cellular responses represents a possible small-molecule therapeutic modality (microbiome-biosynthetic gene therapy).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, a recent paper described that commensal bacteria are able to produce G-protein-coupled receptor agonists to regulate the GI tract physiology, including metabolic hormones and glucose homeostasis [4].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [4]
In the citing paper
“Although microbes secrete eCBs, their role in host physiology remains unclear (255).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [255]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Fu, J., Gaetani, S., Oveisi, F., Verme, J., Serrano, A., de Fonseca, F. D., Rosengarth, A., Luecke, H., Giacomo, B. D., Tarzia, G., et al. (2003) · Nature · doi:10.1038/nature01921 · Cited by 1,113
Relating the metatranscriptome and metagenome of the human gut
Franzosa, E. A., Morgan, X. C., Segata, N., Waldron, L., Reyes, J. A., Earl, A. M., Giannoukos, G., Boylan, M. R., Ciulla, D., Gevers, D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319284111 · Cited by 731
Overton, H. A., Babbs, A. J., Doel, S. M., Fyfe, M. C. T., Gardner, L. S., Griffin, G., Jackson, H. C., Procter, M. J., Rasamison, C. M., Tang‐Christensen, M., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.004 · Cited by 670
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
Kabashima, K., Saji, T., Murata, T., Nagamachi, M., Matsuoka, T., Segi‐Nishida, E., Tsuboi, K., Sugimoto, Y., Kobayashi, T., Miyachi, Y., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14459 · Cited by 443
Modulating the endocannabinoid system in human health and disease – successes and failures
Pacher, P., & Kunos, G. (2013) · FEBS Journal · doi:10.1111/febs.12260 · Cited by 418
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
Kabashima, K., Saji, T., Murata, T., Nagamachi, M., Matsuoka, T., Segi‐Nishida, E., Tsuboi, K., Sugimoto, Y., Kobayashi, T., Miyachi, Y., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214459 · Cited by 418
Lauffer, L. M., Iakoubov, R., & Brubaker, P. L. (2009) · Diabetes · doi:10.2337/db08-1237 · Cited by 405
Chu, Z., Carroll, C., Alfonso, J., Gutierrez, V., He, H., Lucman, A., Pedraza, M., Mondala, H., Gao, H., Bagnol, D., et al. (2008) · Endocrinology · doi:10.1210/en.2007-0966 · Cited by 387
Mimee, M., Tucker, A. C., Voigt, C. A., & Lu, T. K. (2015) · Cell Systems · doi:10.1016/j.cels.2015.06.001 · Cited by 387
Cited by
Sorted by citations
Items 401–499 of 499
Marques, M. E. L., Silva, N. F., Mascarenhas, F. N. A. D. P., Tomiosso, T. C., Júnior, R. J. D. O., Rodrigues, R., Almeida-Souza, H. O., Martins, M. M., Bastos, L. M., Nossol, A. B. D. S., et al. (2025) · Metabolomics · doi:10.1007/s11306-025-02351-y · Cited by 1
“…of tumor cells, not only providing energy for the development and metastasis of cancer cells by promoting fatty acid oxidation but also affecting the occurrence and invasion by other signaling pathways or cytokines, or microRNA (Grapoy et al., 2012; Raboune et al., 2014; Cohen et al., 2017).”
Enteric microbiome and obesity: a multidimensional narrative review
Barat, B., Ghosh, K., Kulkarni, B. P., Banerjee, P., & Ghosh, K. (2025) · Microbial Genomics · doi:10.1099/mgen.0.001562 · Cited by 1
Engin, D., Engin, A. B., & Engin, A. (2026) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2026.104939 · Cited by 1
Li, S., Zhou, C., & Zhang, Q. (2026) · AMB Express · doi:10.1186/s13568-026-02040-6 · Cited by 1
“Based on predictions from the GutMgene database and our correlation analyses, we hypothesize that Roseburia may represent a bacterial genus capable of producing lipid metabolites (Cohen et al. 2017).”
Keremane, P., van Vuuren, A. J., Mumbrekar, K. D., & Vandevoorde, C. (2026) · Life Sciences in Space Research · doi:10.1016/j.lssr.2026.05.004 · Cited by 1
Giorgini, G., Mir, H.-D., Etienne, C., Dumais, E., Maximin, E., Silvestri, C., Flamand, N., Naudon, L., Rabot, S., & Marzo, V. D. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101070 · Cited by 1
“…metabolites such as SCFAs (23, 24) and lipopolysaccharides (LPS) (25 – 27) alter eCB and eCB-like mediator receptor and metabolic enzyme expression in cell cultures or in tissues in vivo; and 3 ) commensal bacteria produce eCB-like molecules capable of acting at the host eCBome receptors (28 – 31).”
Diet, microbiota, and lipidomics: How fatty acids shape the endocannabinoidome and host metabolism
Petrosino, S., Fontecilla-Escobar, J., Marzo, V. D., & Iannotti, F. A. (2026) · Progress in Lipid Research · doi:10.1016/j.plipres.2026.101396 · Cited by 2
Mazarati, A. M., Million, M., Larauche, M. H., & Galanopoulou, A. S. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115940 · Cited by 1
Neves, L. B. M., Daniel Domingues, S., Jr., Baldessarini, B. L., Laino, P. H., & Lima, B. C. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111860 · Cited by 1
Mimics of the chordate gut-brain hormone neurotensin in parasitic intestinal hookworms
Koch, T. L., Yeung, H. Y., Ramiro, I. B. L., Torres, J. P., Vo, A. V., Palomino, S. M., Engholm, E., Robinson, S. D., Rash, L. D., Acyatan, Z. G., et al. (2026) · Current Biology · doi:10.1016/j.cub.2026.07.020 · Cited by 1
汤, 开., 王, 嫣., & 王, 晓. (2019) · SCIENTIA SINICA Terrae · doi:10.1360/n072018-00066 · Cited by 1
The therapeutic role of microbial metabolites in human health and diseases
Manoharan, N., Parasuraman, R., Jayamurali, D., & Govindarajulu, S. N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90113-0.00002-x · Cited by 1
Mining for the Next-Generation Microbiota Across the Gut–Brain Axis
Schellekens, H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00008-4 · Cited by 1
Villano, R., & Marzo, V. D. (2024) · Molecules · doi:10.3390/molecules29153703 · Cited by 1
“…, glsB (BT_3459), which encodes an N -acyltransferase required for the initial production of N -(3-hydroxyacyl)glycines such as commendamide [7,8] (a gut microbiota-derived bioactive metabolite with a very similar structure to long-chain N -acyl amino acids belonging to the endocannabinoidome…”
BackgroundTapping into Metabolomics for Understanding Host and Rotavirus Group A Interactome
Mametja, P. M., Motshudi, M. C., Naidoo, C. M., Rakau, K. G., Seheri, L. M., & Mkolo, N. M. (2025) · Life · doi:10.3390/life15050765 · Cited by 1
“The structural diversity of these lipids has been implicated in the alteration of receptor agonist or antagonist actions [65,66].”
Effects of Normal and Cancer Host Tissues on Microbiota Development, Persistence, and Dynamics
Amadei, S. S., & Notario, V. (2021) · Springer eBooks · doi:10.1007/978-3-030-77595-7_20 · Cited by 1
Metabolic and nutritional aspects of non-alcoholic fatty liver disease
Герасименко, О. Н., Sergeeva, Y. S., & Михайловна, Г. А. (2022) · Ateroscleroz · doi:10.52727/2078-256x-2022-18-2-180-185 · Cited by 1
The Role of Senescence in NASH-Related HCC
Chrysavgis, L., Papadopoulos, G., & Chatzigeorgiou, A. (2022) · Interdisciplinary cancer research · doi:10.1007/16833_2022_87 · Cited by 1
Browne, H. (2018) · LSHTM Research Online (London School of Hygiene and Tropical Medicine) · doi:10.17037/pubs.04647551 · Cited by 2
Molecular Mechanisms of Fungal SignalingPreprint
Jacob, S., Bühring, S., & Bersching, K. (2022) · Preprints.org · doi:10.20944/preprints202203.0168.v1
Ueda, M., Okahashi, N., & Arita, M. (2023) · Wiley eBooks · doi:10.1002/9783527836512.ch27 · Cited by 1
Levi, M. (2009) · Wiley eBooks · doi:10.1002/9780470747919.ch40
Bucci, M. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2507
Papers of note in Nature 549 (7670)
VanHook, A. M. (2017) · Science Signaling · doi:10.1126/scisignal.aap8921
Animal Models When Examining the Gut-Liver Axis
Magdaleno, F., Brol, M. J., Schierwagen, R., Uschner, F. E., Zwick, M., & Trebicka, J. (2018) · Springer eBooks · doi:10.1007/978-3-319-98890-0_14
Bondar, T., Carmona, J. A. D. D., Gao, K., Benedetti, B. L., Basson, M., Levinson, R. S., Stower, H., & Farrell, A. (2017) · Nature Medicine · doi:10.1038/nm1217-1387
Chemistry and Enzymology Encoded by the Human Microbiome
Shine, E. E., Nwe, P.-K., & Crawford, J. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.14659-1
Toxin‐Induced Neurological Diseases
Goossens, P. L., Thépenier, C., & Popoff, M. R. (2020) · doi:10.1002/9781119467748.ch43
Environment-host-microbe interactions shape human metabolism
Chen, L., & Fu, J. (2021) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.171839167
Biological Sensors for Microbiome Diagnostics
Breedon, A. M. E., Beabout, K., Coia, H. G., Davis, C. M., Harbaugh, S. V., Mauzy, C. A., Nelson, M., Saldanha, R., Stamps, B. W., & Goodson, M. S. (2022) · Wiley eBooks · doi:10.1002/9783527825462.ch6
Piel, J., & Rust, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.14722-5
(2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811351-6.00026-7
Shukla, A. K. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735571679.793559171
(2017) · Nature Biotechnology · doi:10.1038/nbt.3985
Deflorin, N., Ehlert, U., & Castro, R. T. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.25.509368
Les lipides bactériens dans la douleur viscérale intestinale
Petitfils, C., & Cénac, N. (2022) · Douleur et Analgésie · doi:10.3166/dea-2022-0221
Kawanabe-Matsuda, H., Takeda, K., Nakamura, M., Makino, S., Karasaki, T., Kakimi, K., Nishimukai, M., Ohno, T., Omi, J., Kano, K., et al. (2023) · doi:10.1158/2159-8290.c.6549610
Maldini, A. C., Calvo, M. L., Schlinder, A., HEREDIA, V. V. O., Marco, R. D., Forlin, G. M. E., González, J. P., Apoloni, S. B., Burgos, M. A., López, C. E., et al. (2023) · Revista de la Sociedad Argentina de Diabetes · doi:10.47196/diab.v57i1.680
PRESTO-Salsa reveals human and microbiota metabolome-GPCRome interactions
Wang, X., & Chen, H. (2023) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2023-0664
Staphylococcus aureus lipid factors modulate melanoma clustering and invasion in zebrafishPreprint
Giese, M., Ramakrishnan, G., Steenberge, L. H., Dovan, J. X., Sauer, J., & Anna Huttenlocher, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.27.582365
Israr, G., An, Y., Qiao, Q., He, S., & Li, Z. (2024) · Research Square · doi:10.21203/rs.3.rs-4089478/v1
Vermeulen, S., Forsman, A. M., & de Bekker, C. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.02.592155
Role of microbiome and microbial extracellular vesicles in tumor microenvironment
Kim, Y. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-824040-3.00002-9
Anandamide: From modulation of neuronal excitation to antimicrobial activities—What is in common?
Sionov, R. V., & Steinberg, D. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19081-0.00017-2
(2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23565-8.09996-8
Consequences of “zombie-making” and generalist fungal pathogens on carpenter ant microbiota
Vermeulen, S., Forsman, A., & de Bekker, C. (2024) · Current Research in Insect Science · doi:10.1016/j.cris.2024.100102
“Some studies suggest that this may occur via microbial metabolites secreted in the gut inter-acting with neurological receptors and G protein coupled receptors (GPCRs) (Aleti et al., 2023, Cohen et al., 2017).”
Harford, T. J., Singh, K. D., Pardhi, T. R., Desnoyer, R. W., Ravi, T., Jara, Z. P., Zalavadia, A. H., Stenson, K. T., Prasad, S. V. N., & Karnik, S. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.29.635371
Mu, X., Feng, L., Wang, Q., Li, H., Zhou, H., Yi, W., & Sun, Y. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5129396
Signal Transduction-Related MPs: GPCR
Zhang, X. C. (2025) · Springer eBooks · doi:10.1007/978-981-96-1321-2_8
Berk, E., Yılmaz, C., & Gökmen, V. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116926
Berk, E., Yılmaz, C., & Gökmen, V. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.146247
Strużek, K., Kwiatkowska, A., Mączka, E., Tracz, W., Świercz, P., Teper, K., Khiralla-Gawlik, S., Strzelecka, A. A., & Basak, A. E. (2025) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.3(47).2025.3662
The endocannabinoidome and its role in the central and peripheral control of food intake
Silvestri, C., & Marzo, V. D. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-13908-6.00013-x
The role of metaorganismal lipid metabolism in human health and disease
Massey, W. J., & Brown, J. M. (2025) · Immunometabolism · doi:10.1097/in9.0000000000000074
“Subsequently, in 2017, six classes of microbial N -acyl synthetases were identified generate N -acyl amide lipids that mimic host N -acyl amide lipids such as N -oleoylethanolamine and agonize host receptors GPR119 and S1PR4 as well as antagonize of PTGIR and PTGER4 [19] .”
Wu, J., Yang, D., Gong, H., Qi, Y., Sun, H., Liu, Y., Liu, Y., & Qiu, X. (2020) · Figshare · doi:10.6084/m9.figshare.13004173
Bourdeau‐Julien, I., Castonguay-Paradis, S., Rochefort, G., Perron, J., Lamarche, B., Flamand, N., Di Marzo, V., Veilleux, A., & Raymond, F. (2023) · Figshare · doi:10.6084/m9.figshare.22615424
Bourdeau‐Julien, I., Castonguay-Paradis, S., Rochefort, G., Perron, J., Lamarche, B., Flamand, N., Di Marzo, V., Veilleux, A., & Raymond, F. (2023) · Figshare · doi:10.6084/m9.figshare.22615421
Wu, J., Yang, D., Gong, H., Qi, Y., Sun, H., Liu, Y., Liu, Y., & Qiu, X. (2020) · Figshare · doi:10.6084/m9.figshare.13004182
Bourdeau‐Julien, I., Castonguay-Paradis, S., Rochefort, G., Perron, J., Lamarche, B., Flamand, N., Di Marzo, V., Veilleux, A., & Raymond, F. (2023) · Figshare · doi:10.6084/m9.figshare.22615418
Bourdeau‐Julien, I., Castonguay-Paradis, S., Rochefort, G., Perron, J., Lamarche, B., Flamand, N., Di Marzo, V., Veilleux, A., & Raymond, F. (2023) · Figshare · doi:10.6084/m9.figshare.22615427
Wu, J., Yang, D., Gong, H., Qi, Y., Sun, H., Liu, Y., Liu, Y., & Qiu, X. (2020) · Figshare · doi:10.6084/m9.figshare.13004176
Bourdeau‐Julien, I., Castonguay-Paradis, S., Rochefort, G., Perron, J., Lamarche, B., Flamand, N., Di Marzo, V., Veilleux, A., & Raymond, F. (2023) · Figshare · doi:10.6084/m9.figshare.22615415
Bourdeau‐Julien, I., Castonguay-Paradis, S., Rochefort, G., Perron, J., Lamarche, B., Flamand, N., Di Marzo, V., Veilleux, A., & Raymond, F. (2023) · Figshare · doi:10.6084/m9.figshare.22615430
Olivares, M., Hernández-Calderón, P., Cárdenas-Brito, S., Liébana-García, R., Sanz, Y., & Benítez‐Páez, A. (2024) · Figshare · doi:10.6084/m9.figshare.26170649
Olivares, M., Hernández-Calderón, P., Cárdenas-Brito, S., Liébana-García, R., Sanz, Y., & Benítez-Páez, A. (2024) · Figshare · doi:10.6084/m9.figshare.26170489
Additional file 1 of Vegetarian diet duration’s influence on women’s gut environment
Deng, X., Si, J., Qu, Y., Jie, L., He, Y., Wang, C., & Zhang, Y. (2021) · Figshare · doi:10.6084/m9.figshare.16726780
Jackson, S. A., Hrab, P., Zdouc, M. M., Clarke, D. J., & Dobson, A. D. W. (2026) · Microbial Genomics · doi:10.1099/mgen.0.001602
“…(similarity score: 0.16) to both I. pellicula phosphonate clusters, is an N - acyl serinol-producing gene cluster from Bacillus sp. 2_A_57_CT2 [76]. cblaster searches revealed that the most similar cluster is from a Chloroflexota MAG assembled from the metagenome of the sponge Aplysina…”
InfluentialMicrobial Metabolite 4EPS Inhibits AT1R to Reduce Blood Pressure and Aortic Aneurysm Outcome
Harford, T. J., Singh, K. D., Pardhi, T. R., Desnoyer, R. W., Ravi, T., Jara, Z. P., Zalavadia, A. H., Stenson, K. T., Prasad, S. V. N., & Karnik, S. S. (2026) · Hypertension · doi:10.1161/hypertensionaha.125.25364
The gut microbiome in obesity: new horizons in personalized medicine
Starodubova, A. V., Кislyak, O. A., Demidova, T. Y., Nikitin, I. G., & Leonov, G. E. (2026) · Terapevticheskii arkhiv · doi:10.26442/00403660.2026.02.203596
Martin‐Gallausiaux, C. (2018) · theses.fr (ABES) · doi:10.70675/c6162413z61d4z4a51z889bze8ca8724b717
Petitfils, C. (2021) · theses.fr (ABES) · doi:10.70675/bc778947z305ez4f0cz8866z05cc7ee3d466
Functional Lipids Produced by Gut Microbiome
SUGIYAMA, I., Morozumi, S., & Arita, M. (2026) · Oleoscience · doi:10.5650/oleoscience.26.183
From an Interest in Molecules to a Fascination with Microbes
Clardy, J. (2026) · Annual Review of Microbiology · doi:10.1146/annurev-micro-042924-030959
GPR35 in host–microbe interaction: Mechanisms and translational prospects
Chen, J., Cai, X., Ma, Q., Hao, H., & Zheng, X. (2026) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2026.05.007
Kim, E. L., Jang, E. S., Nam, Y., Hwang, H.-J., Lee, Y. J., Kim, T. G., Hong, C., & Lee, S. R. (2026) · Journal of Natural Medicines · doi:10.1007/s11418-026-02044-3
“This method allows the direct link between metabolites and their biosynthetic genes and led to the discovery of commendamide, a fatty acid amide from Bacteroides vulgatus that acts as a host GPCR (G2A/ GPR132) ligand encoded by an N -acyltransferase gene [35, 36].”
The expanding role of the microbiome in GLP-1 pharmacology
Massey, W. J., & Brown, J. M. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.05.006
Mphande, K., MacLellan, M. P., Malik, A. A., & Dutta, B. (2026) · MicrobiologyOpen · doi:10.1002/mbo3.70325
Association between PFAS exposure and bilirubin metabolism: A metabolome-wide analysis in children
Zhang, X., Xiang, J., Qin, R., Liu, Q., Chen, Y., Xu, D., Cheng, P., Dong, F., Mo, Z., Pan, Y., et al. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120393
The role of microbiome–mucosal barrier interactions in neoplastic diseases
Toth, E., Sipos, A., Mikó, E., Nyerges, P., & Bai, P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40306-4.00007-7
Christensen, L. V. V., Kjær, V. M. S., Smits, M. M., Arora, T., Louka, S., Beaman, E. E., Manandhar, A., Holst, J. J., Ulven, T., Qvortrup, K. M., et al. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2026.159759
Impact of Gut Microbiota Metabolites on Serotonin Levels in Irritable Bowel Syndrome
Gao, N., Liu, Y., Sun, S., Bin, L., Li, S. N., Yang, T., Yang, W. F. Z., & Wu, J. (2026) · Gut Medicine · doi:10.1002/gtm2.70017
Modulating the human gut microbiome-host system: a new drug discovery paradigm
Colmenarejo, G. (2026) · Frontiers in Drug Discovery · doi:10.3389/fddsv.2026.1898583
Microbiota and lipid mediators: from molecular crosstalk to therapeutic opportunities
Gökcen, B. B., Atabılen, B., Güneş, B. D., Dazıroğlu, M. E. Ç., Özer, Ş. D., Biten, A. A., Pagano, E., Nanì, M. F., Romano, B., Ağagündüz, D., et al. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1836931
“Furthermore, many commensal bacteria can also synthesize eCB-like metabolites (Cohen et al., 2017).”
Petitfils, C., & Cénac, N. (2025) · Dunod eBooks · doi:10.3917/dunod.poisb.2025.01.0910
Comparative Metabolomics Reveals the Production of Sulfated Metabolites by Human Gut Bacteria
D’Agostino, G. D., Kim, C. H., Park, J., Zhang, Y., Amer, B., Franzosa, E. A., Bird, S. S., Huttenhower, C., Huh, J. R., & Devlin, A. S. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c02487
Pulliam, C., Xu, M., Holandez-Lopez, K. S., Xue, D., Shang, Z., Gupta, G., Dioli, O. E., Gou, L., Brodbelt, J. S., Peng, X., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.08.743306
Hsieh, D. C.-C., Jiang, L., Xue, M., Antonovsky, N., & Brady, S. F. (2026) · mSystems · doi:10.1128/msystems.00779-26
“N -Acyl amino acids are common metabolites produced by mammals (14–18) and bacteria (19, 20) and are formed by the condensation between an amino acid and a fatty acid.”
Emerging Microbial Lipid Shifts in a Multistage Simulated Gut Inoculated with Human Fecal Microbiota
Tamanna, I., Salonen, K., Mannochio-Russo, H., Kråkström, M., Gomes, P. W. P., Charron‐Lamoureux, V., Mohanty, I., Forssten, S. D., Ouwehand, A. C., Hyötyläinen, T., et al. (2026) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6c00050 · Cited by 2
Endocannabinoids and related lipids in host metabolism–gut microbiome signalling
Silvestri, C., & Marzo, V. D. (2026) · Nature Reviews Endocrinology · doi:10.1038/s41574-026-01289-y
Metabolic Syndrome: From Mechanisms to Therapeutic Interventions
Yan, M., & Xiang, Q. (2026) · MedComm · doi:10.1002/mco2.70934
“A recent study suggests that gut microbiota may produce specific N-acyl amides structurally similar to human GPCR ligands, as demonstrated by bioinformatics analyses of individual microbiota [ 116 ].”
Microbiota-derived metabolite-GPCR signalling in neurodegeneration
Sharma, A., & Jatana, N. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.09.001
van Best, N., & Hornef, M. W. (2026) · Springer eBooks · doi:10.1007/978-3-032-26410-7_3
Wycislik, A., Adug, J., Rydzak, T., Lewis, I. A., & Buzatto, A. Z. (2026) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6c00565
Schnizlein, M. K., 홍봉진, Nguyen, J. T., Jones, K. A., Rodriguez, A. I., Fiebig, A., Campagna, S. R., Balunas, M. J., O’Halloran, T. V., & Crosson, S. (2026) · mSystems · doi:10.1128/msystems.00749-26 · Cited by 1
“In parallel, N -acyl amides, a broad class of signaling lipids that can function as nutrient sources, bacterial signaling factors, or host G-protein-coupled receptor ligands (47, 48), showed distinct, non-additive alterations.”
Liu, Y., Wang, S., Chen, G., Chen, Z., Li, X., Lin, R., & He, Z. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6c09634
Microbial products trigger chemosensory dialogues through intestinal G protein-coupled receptors
Kadoki, M., ナンキ, コ., Szamosvári, D., Mohamed, A. M. T., Stražar, M., Thurimella, K., 이정호, Yern-Hyerk, S., Ung, P., Shuai, M., et al. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.10.002
Metadata
- Authors
- Cohen, L. J., Esterhazy, D., Kim, S.-H., Lemetre, C., Aguilar, R. R., Gordon, E. A., Pickard, A. J., Cross, J. R., Emiliano, A. B., Han, S. M., Chu, J., Vila-Farres, X., Kaplitt, J., Rogoz, A., Calle, P. Y., Hunter, C., Bitok, J. K., & Brady, S. F.
- Affiliations
- Rockefeller University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Brady, Sean F.
- ORCID
- Venue
- Nature
- Published
- 2017-08-30
- Volume
- 549
- Issue
- 7670
- Pages
- 48-53
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5777231
- OpenAlex
- W2753100975
- Cited by
- 500
- References
- 45
- Citations by year
- 2026: 44 · 2025: 47 · 2024: 60 · 2023: 53 · 2022: 52 · 2021: 44 · 2020: 64 · 2019: 62 · 2018: 55 · 2017: 18
- FWCI
- 22.22
- Type
- journal article
- Language
- en
- Update notices
- erratum (2018-04-05)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Crohn's and Colitis Foundation (370629)
- National Institute of General Medical Sciences (U01GM110714, R35GM122559)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007792, K08DK109287)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- commensal bacteria, G protein-coupled receptors, GPR119, gut microbiota metabolites, glucose homeostasis, metabolic hormones, gastrointestinal tract physiology
- MeSH terms
- Biological Mimicry, Gastrointestinal Microbiome, Amides, Animals, Bacteria, Blood Glucose, Female, Homeostasis, Humans, Ligands, Male, Symbiosis, Signal Transduction, Gastrointestinal Tract, Receptors, G-Protein-Coupled, Mice, HEK293 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
