Cross, Justin R.

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature

Gut microbiota and healthT-cell and B-cell Immunology

Cited by 4,838

ATP-citrate lyase links cellular metabolism to histone acetylation

Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science

Genomics and Chromatin DynamicsHistone Deacetylase Inhibitors Research

Cited by 2,298

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

Ward, P. S., Patel, J., Wise, D. R., Abdel-Wahab, O., Bennett, B. D., Coller, H. A., Cross, J. R., Fantin, V. R., Hedvat, C. V., Perl, A. E., et al. (2010) · Cancer Cell

Acute Myeloid Leukemia ResearchCancer, Hypoxia, and Metabolism

Cited by 2,020

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

Buffie, C. G., Bucci, V., Stein, R. R., McKenney, P. T., Ling, L., Gobourne, A., No, D., Liu, H., Kinnebrew, M., Viale, A., et al. (2015) · Nature

Clostridium difficile and Clostridium perfringens researchGut microbiota and health

Cited by 1,872

Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation

Krawczyk, C. M., Holowka, T., Sun, J., Blagih, J., Amiel, E., DeBerardinis, R. J., Cross, J. R., Jung, E., Thompson, C. B., Jones, R. G., et al. (2010) · Blood

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 1,246

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

Carey, B. W., Finley, L. W. S., Cross, J. R., Allis, C. D., & Thompson, C. B. (2015) · Nature

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 1,007

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

Wise, D. R., Ward, P. S., Shay, J. E. S., Cross, J. R., Gruber, J. J., Sachdeva, U. M., Platt, J. M., DeMatteo, R. G., Simon, M. C., & Thompson, C. B. (2011) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 975

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

Chen, Q., Boire, A., Jin, X., Valiente, M., Er, E. E., Lopez-Soto, A., S. Jacob, L., Patwa, R., Shah, H., Xu, K., et al. (2016) · Nature

Connexins and lens biologyBrain Metastases and Treatment

Cited by 969

Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia

Santomasso, B. D., Park, J. H., Salloum, D., Riviere, I., Flynn, J., Mead, E., Halton, E., Wang, X., Senechal, B., Purdon, T., et al. (2018) · Cancer Discovery

CAR-T cell therapy researchAcute Lymphoblastic Leukemia research

Cited by 942

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

Campbell, C., McKenney, P. T., Konstantinovsky, D., Isaeva, O. I., Schizas, M., Verter, J., Mai, C., Jin, W.-B., Guo, C.-J., Violante, S., et al. (2020) · Nature

T-cell and B-cell ImmunologyGut microbiota and health

Cited by 901

Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease

Jenq, R. R., Taur, Y., Devlin, S. M., Ponce, D. M., Goldberg, J. D., Ahr, K. F., Littmann, E. R., Ling, L., Gobourne, A. C., Miller, L. C., et al. (2015) · Biology of Blood and Marrow Transplantation

Gut microbiota and healthHematopoietic Stem Cell Transplantation

Cited by 748

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

Kamphorst, J. J., Cross, J. R., Fan, J., de Stanchina, E., Mathew, R., White, E. P., Thompson, C. B., & Rabinowitz, J. D. (2013) · Proceedings of the National Academy of Sciences

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 726

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

Sabari, B. R., Tang, Z., Huang, H., Yong-Gonzalez, V., Molina, H., Kong, H. E., Dai, L., Shimada, M., Cross, J. R., Zhao, Y., et al. (2015) · Molecular Cell

Genomics and Chromatin DynamicsHistone Deacetylase Inhibitors Research

Cited by 659

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

Vardhana, S. A., Hwee, M. A., Berisa, M., Wells, D. K., Yost, K. E., King, B., Smith, M., Herrera, P. S., Chang, H. Y., Satpathy, A. T., et al. (2020) · Nature Immunology

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 575

Hypoxia Induces Production of L-2-Hydroxyglutarate

Intlekofer, A. M., Dematteo, R. G., Venneti, S., Finley, L. W. S., Lu, C., Judkins, A. R., Rustenburg, A. S., Grinaway, P. B., Chodera, J. D., Cross, J. R., et al. (2015) · Cell Metabolism

Cancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation

Cited by 513

Commensal bacteria make GPCR ligands that mimic human signalling molecules

Cohen, L. J., Esterhazy, D., Kim, S.-H., Lemetre, C., Aguilar, R. R., Gordon, E. A., Pickard, A. J., Cross, J. R., Emiliano, A. B., Han, S. M., et al. (2017) · Nature

Gut microbiota and healthMicrobial Natural Products and Biosynthesis

Cited by 500

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Ye, J., Fan, J., Venneti, S., Wan, Y.-W., Pawel, B. R., Zhang, J., Finley, L. W. S., Lu, C., Lindsten, T., Cross, J. R., et al. (2014) · Cancer Discovery

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 452

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

Zhang, J., Fan, J., Venneti, S., Cross, J. R., Takagi, T., Bhinder, B., Djaballah, H., Kanai, M., Cheng, E. H., Judkins, A. R., et al. (2014) · Molecular Cell

Amino Acid Enzymes and MetabolismCancer, Hypoxia, and Metabolism

Cited by 439

Lactose drives Enterococcus expansion to promote graft-versus-host disease

Stein-Thoeringer, C. K., Nichols, K. B., Lazrak, A., Docampo, M. D., Slingerland, A. E., Slingerland, J. B., Clurman, A. G., Armijo, G., Gomes, A. L. C., Shono, Y., et al. (2019) · Science

Hematopoietic Stem Cell TransplantationGut microbiota and health

Cited by 384

Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy

Smith, M., Dai, A., Ghilardi, G., Amelsberg, K. V., Devlin, S. M., Pajarillo, R., Slingerland, J. B., Beghi, S., Herrera, P. S., Giardina, P., et al. (2022) · Nature Medicine

CAR-T cell therapy researchGut microbiota and health

Cited by 349

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation

Su, X., Yu, Y., Zhong, Y., Giannopoulou, E. G., Hu, X., Liu, H., Cross, J. R., Rätsch, G., Rice, C. M., & Ivashkiv, L. B. (2015) · Nature Immunology

PI3K/AKT/mTOR signaling in cancerImmune cells in cancer

Cited by 298

The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis

Govek, E.-E., Newey, S. E., Akerman, C. J., Cross, J. R., Van der Veken, L., & Van Aelst, L. (2004) · Nature Neuroscience

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 293

Cellular ATP demand creates metabolically distinct subpopulations of mitochondria

Ryu, K. W., Fung, T. S., Baker, D. C., Saoi, M., Park, J., Febres-Aldana, C. A., Aly, R. G., Cui, R., Sharma, A., Fu, Y., et al. (2024) · Nature

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 284

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

Intlekofer, A. M., Shih, A. H., Wang, B., Nazir, A., Rustenburg, A. S., Albanese, S. K., Patel, M., Famulare, C., Correa, F. M., Takemoto, N., et al. (2018) · Nature

Acute Myeloid Leukemia ResearchGlioma Diagnosis and Treatment

Cited by 281