The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation
Open accessAbstract
Neuronal growth cones are guided to their targets by attractive and repulsive guidance cues. In mammals, netrin-1 is a bifunctional cue, attracting some axons and repelling others. Deleted in colorectal cancer (Dcc) is a receptor for netrin-1 that mediates its chemoattractive effect on commissural axons, but the signalling mechanisms that transduce this effect are poorly understood. Here we show that Dcc activates mitogen-activated protein kinase (MAPK) signalling, by means of extracellular signal-regulated kinase (ERK)-1 and -2, on netrin-1 binding in both transfected cells and commissural neurons. This activation is associated with recruitment of ERK-1/2 to a Dcc receptor complex. Inhibition of ERK-1/2 antagonizes netrin-dependent axon outgrowth and orientation. Thus, activation of MAPK signalling through Dcc contributes to netrin signalling in axon growth and guidance.
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Cites
3 retracted
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Self-citationRetractedStein, E., & Tessier-Lavigne, M. (2001) · Science · doi:10.1126/science.1058445 · Cited by 601
Self-citationRetractedStein, E., Zou, Y., Poo, M.-M., & Tessier-Lavigne, M. (2001) · Science · doi:10.1126/science.1059391 · Cited by 242
Self-citationRetractedMammalian MAP kinase signalling cascades
Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,111
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The Molecular Biology of Axon Guidance
Tessier-Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,278
Self-citationThe netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
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Self-citationNetrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
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Self-citationNetrin-1 Is Required for Commissural Axon Guidance in the Developing Vertebrate Nervous System
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Self-citationOrganization and regulation of mitogen-activated protein kinase signaling pathways
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Cited by
Huber, A. B., Kolodkin, A. L., Ginty, D. D., & Cloutier, J.-F. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.010302.081139 · Cited by 719
Axonal Protein Synthesis and Degradation Are Necessary for Efficient Growth Cone Regeneration
Verma, P., Chierzi, S., Codd, A. M., Campbell, D. S., Meyer, R. L., Holt, C. E., & Fawcett, J. W. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3073-04.2005 · Cited by 406
Neurotrophic factors and axonal growth
Markus, A., Patel, T. D., & Snider, W. D. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00372-0 · Cited by 310
Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones
Campbell, D. S., & Holt, C. E. (2003) · Neuron · doi:10.1016/s0896-6273(03)00158-2 · Cited by 303
Signalling mechanisms mediating neuronal responses to guidance cues
Guan, K.-L., & Rao, Y. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1254 · Cited by 289
Metadata
- Authors
- Forcet, C., Stein, E., Pays, L., Corset, V., Llambi, F., Tessier-Lavigne, M., & Mehlen, P.
- Venue
- Nature
- Published
- 2002-05
- Volume
- 417
- Issue
- 6887
- Pages
- 443-447
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1997990793
- Cited by
- 273
- References
- 29
- FWCI
- 7.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Forcet, C., Stein, E., Pays, L., Corset, V., Llambi, F., Tessier-Lavigne, M., & Mehlen, P. (2002). Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature. https://doi.org/10.1038/nature748
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