The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML
Open accessAbstract
Cancer stem cells have been proposed to be important for initiation, maintenance and recurrence of various malignancies, including acute myeloid leukemia (AML). We have previously reported that CD34+CD38− human primary AML stem cells residing in the endosteal region of the bone marrow are relatively chemotherapy resistant. Using a NOD/SCID/IL2rγnull mouse model of human AML, we now show that the AML stem cells in the endosteal region are cell cycle quiescent and that these stem cells can be induced to enter the cell cycle by treatment with granulocyte colony-stimulating factor (G-CSF). In combination with cell cycle-dependent chemotherapy, G-CSF treatment significantly enhances induction of apoptosis and elimination of human primary AML stem cells in vivo. The combination therapy leads to significantly increased survival of secondary recipients after transplantation of leukemia cells compared with chemotherapy alone.
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Cited by
The cancer stem cell: premises, promises and challenges
Clevers, H. (2011) · Nature Medicine · doi:10.1038/nm.2304 · Cited by 1,923
The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?
Plaks, V., Kong, N., & Werb, Z. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.02.015 · Cited by 1,557
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Manz, M. G., & Boettcher, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3660 · Cited by 855
Stem cells and the impact of ROS signaling
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Metadata
- Authors
- Saito, Y., Uchida, N., Tanaka, S., Suzuki, N., Tomizawa-Murasawa, M., Sone, A., Najima, Y., Takagi, S., Aoki, Y., Wake, A., Taniguchi, S., Shultz, L. D., & Ishikawa, F.
- Venue
- Nature Biotechnology
- Published
- 2010-02-14
- Volume
- 28
- Issue
- 3
- Pages
- 275-280
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2092296376
- Cited by
- 419
- References
- 5
- FWCI
- 18.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Saito, Y., Uchida, N., Tanaka, S., Suzuki, N., Tomizawa-Murasawa, M., Sone, A., Najima, Y., Takagi, S., Aoki, Y., Wake, A., Taniguchi, S., Shultz, L. D., & Ishikawa, F. (2010). Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML. Nature Biotechnology. https://doi.org/10.1038/nbt.1607
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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