The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3
Open accessAbstract
Insulin-expressing cells that have been differentiated from human pluripotent stem cells in vitro lack the glucose responsiveness characteristic of mature beta cells. Beta-cell maturation in mice was studied to find genetic markers that enable screens for factors that induce bona fide beta cells in vitro. We find that functional beta-cell maturation is marked by an increase in the glucose threshold for insulin secretion and by expression of the gene urocortin 3.
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Pancreas organogenesis: From bud to plexus to gland
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Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity
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MafA and MafB Regulate Genes Critical to β-Cells in a Unique Temporal Manner
Artner, I., Hang, Y., Mazur, M., Yamamoto, T., Guo, M., Lindner, J., Magnuson, M. A., & Stein, R. (2010) · Diabetes · doi:10.2337/db10-0190 · Cited by 243
Production of Functional Glucagon-Secreting α-Cells From Human Embryonic Stem Cells
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Self-citationUrocortin III Is Expressed in Pancreatic β-Cells and Stimulates Insulin and Glucagon Secretion
Li, C., Chen, P., Vaughan, J. M., Blount, A. L., Chen, A., Jamieson, P. M., Rivier, J., Smith, M. S., & Vale, W. (2003) · Endocrinology · doi:10.1210/en.2002-0087 · Cited by 131
Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis
Li, C., Chen, P., Vaughan, J. M., Lee, K., & Vale, W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611641104 · Cited by 123
Foxa1 and Foxa2 Maintain the Metabolic and Secretory Features of the Mature β-Cell
Gao, N., Lay, J. E. L., Qin, W. D., Doliba, N. M., Schug, J., Fox, A. J., Smirnova, O., Matschinsky, F. M., & Kaestner, K. H. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0513 · Cited by 113
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Cited by
Generation of Functional Human Pancreatic β Cells In Vitro
Pagliuca, F. W., Millman, J. R., Gürtler, M., Segel, M., Van Dervort, A., Ryu, J. H., Peterson, Q. P., Greiner, D., & Melton, D. A. (2014) · Cell · doi:10.1016/j.cell.2014.09.040 · Cited by 2,025
Self-citationBaron, M., Veres, A., Wolock, S. L., Faust, A. L., Gaujoux, R., Vetere, A., Ryu, J. H., Wagner, B. K., Shen-Orr, S. S., Klein, A. M., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.08.011 · Cited by 1,508
Self-citationHuman iPSC-based modeling of late-onset disease via progerin-induced aging
Miller, J. D., Ganat, Y. M., Kishinevsky, S., Bowman, R. L., Liu, B., Tu, E. Y., Mandal, P. K., Vera, E., Shim, J.-W., Kriks, S., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.11.006 · Cited by 777
Charting cellular identity during human in vitro β-cell differentiation
Veres, A., Faust, A. L., Bushnell, H. L., Engquist, E. N., Kenty, J. H.-R., Harb, G., Poh, Y.-C., Sintov, E., Gürtler, M., Pagliuca, F. W., et al. (2019) · Nature · doi:10.1038/s41586-019-1168-5 · Cited by 552
Self-citationNair, G. G., Liu, J. S., Russ, H. A., Tran, S., Saxton, M. S., Chen, R., Juang, C., Li, M.-L., Nguyen, V. Q., Giacometti, S., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0271-4 · Cited by 472
Metadata
- Authors
- Blum, B., Hrvatin, S., Schuetz, C., Bonal, C., Rezania, A., & Melton, D. A.
- Venue
- Nature Biotechnology
- Published
- 2012-02-26
- Volume
- 30
- Issue
- 3
- Pages
- 261-264
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2056203351
- Cited by
- 366
- References
- 14
- FWCI
- 17.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Blum, B., Hrvatin, S., Schuetz, C., Bonal, C., Rezania, A., & Melton, D. A. (2012). Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3. Nature Biotechnology. https://doi.org/10.1038/nbt.2141
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