The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Pancreas organogenesis: From bud to plexus to gland
Open accessAbstract
Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling events and transcriptional networks that guide a step‐wise process of organ development from early bud specification all the way to the final mature organ state. Extensive research on pancreas development over the last few years, largely driven by a translational potential for pancreatic diseases (diabetes, pancreatic cancer, and so on), is markedly advancing our knowledge of these processes. It is a tenable goal that we will one day have a clear, complete picture of the transcriptional and signaling codes that control the entire organogenetic process, allowing us to apply this knowledge in a therapeutic context, by generating replacement cells in vitro, or perhaps one day to the whole organ in vivo. This review summarizes findings in the past 5 years that we feel are amongst the most significant in contributing to the deeper understanding of pancreas development. Rather than try to cover all aspects comprehensively, we have chosen to highlight interesting new concepts, and to discuss provocatively some of the more controversial findings or proposals. At the end of the review, we include a perspective section on how the whole pancreas differentiation process might be able to be unwound in a regulated fashion, or redirected, and suggest linkages to the possible reprogramming of other pancreatic cell‐types in vivo, and to the optimization of the forward‐directed‐differentiation of human embryonic stem cells (hESC), or induced pluripotential cells (iPSC), towards mature β‐cells. Developmental Dynamics 240:530–565, 2011. © 2011 Wiley‐Liss, Inc.
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Citations
Cites
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., & Melton, D. A. (2008) · Nature · doi:10.1038/nature07314 · Cited by 2,010
Kroon, E., Martinson, L. A., Kadoya, K., Bang, A. G., Kelly, O. G., Eliazer, S., Young, H., Richardson, M., Smart, N. G., Cunningham, J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1393 · Cited by 1,843 · cited 2×
“Furthermore, it is necessary to determine the specific differences in the genetic program between rodents and humans, so that in vitro differentiation is not misled by knowledge gained solely from rodent studies (D’Amour et al., 2006; Kroon et al., 2008).”
BackgroundAsymmetric self-renewal and commitment of satellite stem cells in muscle
Kuang, S., Kuroda, K., Le Grand, F., & Rudnicki, M. A. (2007) · Cell · doi:10.1016/j.cell.2007.03.044 · Cited by 1,449 · cited 1×
“This mechanism of progenitor cell self-renewal coupled with cell commitment-differentiation has been reported during neurogenesis in the developing central nervous system, and in dividing muscle satellite stem cells during regeneration (Huttner and Kosodo, 2005; Kuang et al., 2007).”
BackgroundConversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
Thorel, F., Népote, V., Avril, I., Kohno, K., Desgraz, R., Chera, S., & Herrera, P. L. (2010) · Nature · doi:10.1038/nature08894 · Cited by 1,136
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
Kawaguchi, Y., Cooper, B., Gannon, M., Ray, M., MacDonald, R. J., & Wright, C. V. E. (2002) · Nature Genetics · doi:10.1038/ng959 · Cited by 1,007 · cited 5×
“‘‘Global deletion’’ of Pdx1 or Ptf1a in the early foregut epithelium blocks pancreas development and subsequently allows only large cystic ducts to form (Offield et al., 1996; Kawaguchi et al., 2002).”
BackgroundResultInfluentialSelf-citationBrissova, M., Fowler, M. J., Nicholson, W. E., Chu, A., Hirshberg, B., Harlan, D. M., & Powers, A. C. (2005) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5c6684.2005 · Cited by 797
Depletion of definitive gut endoderm in Sox17 -null mutant mice
Kanai-Azuma, M., Kanai, Y., Gad, J. M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P. P. L., et al. (2002) · Development · doi:10.1242/dev.129.10.2367 · Cited by 704
Very Slow Turnover of β-Cells in Aged Adult Mice
Teta, M., Long, S. Y., Wartschow, L. M., Rankin, M. M., & Kushner, J. A. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2557 · Cited by 465
Regulation of pancreas development by hedgehog signaling
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Cited by
Churchill, A. J., Gutiérrez, G. D., Singer, R. A., Lorberbaum, D. S., Fischer, K. A., & Sussel, L. (2017) · eLife · doi:10.7554/elife.20010 · Cited by 1,236
Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro
Russ, H. A., Parent, A. V., Ringler, J. J., Hennings, T. G., Nair, G. G., Shveygert, M., Guo, T., Puri, S., Haataja, L., Cirulli, V., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201591058 · Cited by 591
Inactivation of specific β cell transcription factors in type 2 diabetes
Guo, S., Dai, C., Guo, M., Taylor, B., Harmon, J. S., Sander, M., Robertson, R. P., Powers, A. C., & Stein, R. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65390 · Cited by 520
Blum, B., Hrvatin, S., Schuetz, C., Bonal, C., Rezania, A., & Melton, D. A. (2012) · Nature Biotechnology · doi:10.1038/nbt.2141 · Cited by 366
Kelly, O. G., Chan, M. Y., Martinson, L. A., Kadoya, K., Ostertag, T. M., Ross, K. G., Richardson, M., Carpenter, M. K., D'Amour, K. A., Kroon, E., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1931 · Cited by 348
Metadata
- Authors
- Pan, F. C., & Wright, C.
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2011-02-17
- Volume
- 240
- Issue
- 3
- Pages
- 530-565
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- OpenAlex
- W2089688272
- Cited by
- 614
- References
- 17
- FWCI
- 43.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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