Combinatorial drug therapy for cancer in the post-genomic era

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Items 201–300 of 999

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4. SNRMPACDC: computational model focused on Siamese network and random matrix projection for anticancer synergistic drug combination prediction
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5. Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen
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6. A Nano-in-Nano Polymer–Dendrimer Nanoparticle-Based Nanosystem for Controlled Multidrug Delivery
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7. Synergy between Auranofin and Celecoxib against Colon Cancer In Vitro and In Vivo through a Novel Redox-Mediated Mechanism
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8. Construction of Smart Manganese Dioxide‐Based All‐in‐One Nanoplatform for Cancer Diagnosis and Therapy
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9. Systematic review of computational methods for drug combination prediction
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11. Massively parallel high-order combinatorial genetics in human cells
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12. Combinatorial delivery of Crizotinib–Palbociclib–Sildenafil using TPGS-PLA micelles for improved cancer treatment
    Duarte de Melo‐Diogo, Vítor M. Gaspar, Elisabete C. Costa, André Ferreira Moreira, David Oppolzer, Eugénia Gallardo, Ilídio Joaquim Correia · 2014 · European Journal of Pharmaceutics and Biopharmaceutics
13. Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology
    Paul Workman, Bissan Al‐Lazikani, Paul Andrew Clarke · 2013 · Current Opinion in Pharmacology
14. Single-cell transcriptomes identify patient-tailored therapies for selective co-inhibition of cancer clones
    Aleksandr Ianevski, Kristen Michelle Nader, Kyriaki Driva, Wojciech Senkowski, Daria R. Bulanova, Lidia Moyano‐Galceran, Tanja M. Ruokoranta, Heikki A Kuusanmäki, Nemo Ikonen, Philipp Sergeev et al. · 2024 · Nature Communications
15. Triple-drug Therapy With Bevacizumab, Irinotecan, and Temozolomide Plus Tumor Treating Fields for Recurrent Glioblastoma: A Retrospective Study
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16. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase
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17. Nanomedicines as emerging platform for simultaneous delivery of cancer therapeutics: new developments in overcoming drug resistance and optimizing anticancer efficacy
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18. A Biodegradable Polymersome Containing Bcl‐xL siRNA and Doxorubicin as a Dual Delivery Vehicle for a Synergistic Anticancer Effect
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19. Tumor homing and penetrating peptide-conjugated niosomes as multi-drug carriers for tumor-targeted drug delivery
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20. Drug Combinations: Mathematical Modeling and Networking Methods
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21. Orthogonally Functionalized Nanoscale Micelles for Active Targeted Codelivery of Methotrexate and Mitomycin C with Synergistic Anticancer Effect
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22. SRR-DDI: A drug–drug interaction prediction model with substructure refined representation learning based on self-attention mechanism
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23. c-Myc Alterations Confer Therapeutic Response and Acquired Resistance to c-Met Inhibitors in MET-Addicted Cancers
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24. Engineered Nanoparticles Against MDR in Cancer: The State of the Art and its Prospective
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25. Synergistic breast cancer suppression efficacy of doxorubicin by combination with glycyrrhetinic acid as an angiogenesis inhibitor
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26. Design and evaluation of cabazitaxel loaded NLCs against breast cancer cell lines
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27. A nano vector with photothermally enhanced drug release and retention to overcome cancer multidrug resistance
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28. AI-powered omics-based drug pair discovery for pyroptosis therapy targeting triple-negative breast cancer
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29. Emerging anti-cancer antibodies and combination therapies targeting HER3/ERBB3
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30. Drosophila Cancer Models Identify Functional Differences Between Ret Fusions
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31. Mapping the perturbome network of cellular perturbations
    Michael Caldera, Felix Müller, Isabel Kaltenbrunner, Marco P. Licciardello, Charles-Hugues Lardeau, Stefan Kubicek, Jörg Menche · 2019 · Nature Communications
32. Predicting effective drug combinations using gradient tree boosting based on features extracted from drug-protein heterogeneous network
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33. A high-throughput drug combination screen of targeted small molecule inhibitors in cancer cell lines
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34. Thermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells
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35. Chlorin e6 Functionalized Theranostic Multistage Nanovectors Transported by Stem Cells for Effective Photodynamic Therapy
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36. Stratification and prediction of drug synergy based on target functional similarity
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37. Cisplatin-Stitched Polysaccharide Vesicles for Synergistic Cancer Therapy of Triple Antagonistic Drugs
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38. Lysine-embedded cellulose-based nanosystem for efficient dual-delivery of chemotherapeutics in combination cancer therapy
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39. Synergistic Anticancer Activity of Arsenic Trioxide with Erlotinib Is Based on Inhibition of EGFR-Mediated DNA Double-Strand Break Repair
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40. Preclinical activity of the repurposed drug auranofin in classical Hodgkin lymphoma
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41. Distinctive Behaviors of Druggable Proteins in Cellular Networks
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42. Redox-Responsive Polyphosphoester-Based Micellar Nanomedicines for Overriding Chemoresistance in Breast Cancer Cells
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43. Synthesis and investigation of novel 6-(1,2,3-triazol-4-yl)-4-aminoquinazolin derivatives possessing hydroxamic acid moiety for cancer therapy
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44. Optimal control nodes in disease-perturbed networks as targets for combination therapy
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45. Soft Nanohydrogels Based on Laponite Nanodiscs: A Versatile Drug Delivery Platform for Theranostics and Drug Cocktails
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46. CHARACTERISTICS OF DRUG COMBINATION THERAPY IN ONCOLOGY BY ANALYZING CLINICAL TRIAL DATA ON CLINICALTRIALS.GOV
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47. Near-Infrared Cyanine-Loaded Liposome-like Nanocapsules of Camptothecin–Floxuridine Conjugate for Enhanced Chemophotothermal Combination Cancer Therapy
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48. Suppression of stress induction of the 78-kilodalton glucose regulated protein (GRP78) in cancer by IT-139, an anti-tumor ruthenium small molecule inhibitor
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49. Drug conjugates—an emerging approach to treat breast cancer
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50. Polymeric Nanomaterials
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51. HOXA13 contributes to gastric carcinogenesis through DHRS2 interacting with MDM2 and confers 5‐FU resistance by a p53‐dependent pathway
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52. Utility of the JAX Clinical Knowledgebase in capture and assessment of complex genomic cancer data
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53. Experimentally-driven mathematical modeling to improve combination targeted and cytotoxic therapy for HER2+ breast cancer
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54. Reconstituted high density lipoprotein (rHDL), a versatile drug delivery nanoplatform for tumor targeted therapy
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55. Formulation and design optimization of nano-transferosomes using pioglitazone and eprosartan mesylate for concomitant therapy against diabetes and hypertension
    Sundarapandian Ramkanth, P. Anitha, R. Gayathri, Sellapan Mohan, Dinesh Babu · 2021 · European Journal of Pharmaceutical Sciences
56. Learning interpretable cellular responses to complex perturbations in high-throughput screens
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57. Exploring the Genetic Orchestra of Cancer: The Interplay Between Oncogenes and Tumor-Suppressor Genes
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58. PET, MRI, and simultaneous PET/MRI in the development of diagnostic and therapeutic strategies for glioma
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59. Solid matrix-based lipid nanoplatforms as carriers for combinational therapeutics in cancer
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60. Dual controlled delivery of squalenoyl-gemcitabine and paclitaxel using thermo-responsive polymeric micelles for pancreatic cancer
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61. Fabrication of polydopamine-based layer-by-layer nanocomposites for combined pH-sensitive chemotherapy and photothermal therapy
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62. Mutation Rate Heterogeneity Increases Odds of Survival in Unpredictable Environments
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63. High-throughput screening reveals higher synergistic effect of MEK inhibitor combinations in colon cancer spheroids
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64. Personalized drug combinations to overcome trastuzumab resistance in HER2-positive breast cancer
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65. Microfluidic-Enabled Print-to-Screen Platform for High-Throughput Screening of Combinatorial Chemotherapy
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66. Approaches to Multireceptor Targeting: Hybrid Radioligands, Radioligand Cocktails, and Sequential Radioligand Applications
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67. A Microdevice Platform Recapitulating Hypoxic Tumor Microenvironments
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68. Engineered Zn(II)-Dipicolylamine-Gold Nanorod Provides Effective Prostate Cancer Treatment by Combining siRNA Delivery and Photothermal Therapy
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69. Targeting the MMP-14/MMP-2/integrin αvβ3 axis with multispecific N-TIMP2–based antagonists for cancer therapy
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70. RBP EIF2S2 Promotes Tumorigenesis and Progression by Regulating MYC-Mediated Inhibition via FHIT-Related Enhancers
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71. A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets
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72. Mutant Allele Tumor Heterogeneity (MATH) and Head and Neck Squamous Cell Carcinoma
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73. Enhancing Targeted Tumor Treatment by Near IR Light-Activatable Photodynamic–Photothermal Synergistic Therapy
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74. Targeting homologous recombination-mediated DNA repair in cancer
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75. Spadix-Bract Structured Nanobowls for Bimodal Imaging-Guided Multidrug Chemo-Photothermal Synergistic Therapy
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76. The Mitochondrial Chaperone TRAP1 as a Candidate Target of Oncotherapy
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77. Repurposing FDA-approved drugs against the toxicity of platinum-based anticancer drugs
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78. Dual inhibitors of HDAC and other epigenetic regulators: A novel strategy for cancer treatment
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79. Armed Therapeutic Viruses – A Disruptive Therapy on the Horizon of Cancer Immunotherapy
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80. Enhanced killing of antibiotic-resistant bacteria enabled by massively parallel combinatorial genetics
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81. Identification of the S100 fused-type protein hornerin as a regulator of tumor vascularity
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82. NIR-Triggered Chemo-Photothermal Therapy by Thermosensitive Gold Nanostar@Mesoporous Silica@Liposome-Composited Drug Delivery Systems
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83. A new pyridazinone exhibits potent cytotoxicity on human cancer cells via apoptosis and poly-ubiquitinated protein accumulation
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84. Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat
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85. CCSynergy: an integrative deep-learning framework enabling context-aware prediction of anti-cancer drug synergy
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86. Radiolabeled Polymeric Nanoconstructs Loaded with Docetaxel and Curcumin for Cancer Combinatorial Therapy and Nuclear Imaging
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87. Modeling Tumor Clonal Evolution for Drug Combinations Design
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88. Frequent amplification of receptor tyrosine kinase genes in well-differentiated/ dedifferentiated liposarcoma
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89. Cabazitaxel and thymoquinone co-loaded lipospheres as a synergistic combination for breast cancer
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90. Codelivery of doxorubicin and camptothecin by dual-responsive unimolecular micelle-based β-cyclodextrin for enhanced chemotherapy
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91. Attribute Supervised Probabilistic Dependent Matrix Tri-Factorization Model for the Prediction of Adverse Drug-Drug Interaction
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92. Predicting Drug Response in Human Prostate Cancer from Preclinical Analysis of In Vivo Mouse Models
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93. New tools for old drugs: Functional genetic screens to optimize current chemotherapy
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94. Investigation on Physicochemical Characteristics of a Nanoliposome-Based System for Dual Drug Delivery
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95. Landscape of combination therapy trials in breast cancer brain metastasis
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96. Transforming cancer drug discovery with Big Data and AI
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97. Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines
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98. A New Drug Combinatory Effect Prediction Algorithm on the Cancer Cell Based on Gene Expression and Dose–Response Curve
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99. Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential
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100. Achiral Mannich-Base Curcumin Analogs Induce Unfolded Protein Response and Mitochondrial Membrane Depolarization in PANC-1 Cells
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