Workman, Paul

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

Vlachogiannis, G., Hedayat, S., Vatsiou, A., Jamin, Y., Fernández-Mateos, J., Khan, K., Lampis, A., Eason, K., Huntingford, I., Burke, R., et al. (2018) · Science

Cancer Cells and MetastasisColorectal Cancer Treatments and Studies

Cited by 2,096

Imaging biomarker roadmap for cancer studies

O'Connor, J. P. B., Aboagye, E. O., Adams, J. E., Aerts, H. J. W. L., Barrington, S. F., Beer, A. J., Boellaard, R., Bohndiek, S. E., Brady, M., Brown, G., et al. (2017) · Nature Reviews Clinical Oncology

Medical Imaging Techniques and ApplicationsRadiomics and Machine Learning in Medical Imaging

Cited by 1,091

Combinatorial drug therapy for cancer in the post-genomic era

Al-Lazikani, B., Banerji, U., & Workman, P. (2012) · Nature Biotechnology

Cancer Genomics and DiagnosticsLung Cancer Treatments and Mutations

Cited by 1,070

Challenges to curing primary brain tumours

Aldape, K., Brindle, K. M., Chesler, L., Chopra, R., Gajjar, A., Gilbert, M. R., Gottardo, N., Gutmann, D. H., Hargrave, D., Holland, E. C., et al. (2019) · Nature Reviews Clinical Oncology

Glioma Diagnosis and TreatmentBrain Metastases and Treatment

Cited by 959

The promise and peril of chemical probes

Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., et al. (2015) · Nature Chemical Biology

Click Chemistry and ApplicationsComputational Drug Discovery Methods

Cited by 839

Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

Yap, T. A., Garrett, M. D., Walton, M. I., Raynaud, F., de Bono, J. S., & Workman, P. (2008) · Current Opinion in Pharmacology

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 543

HSP90 as a new therapeutic target for cancer therapy: the story unfolds

Maloney, A., & Workman, P. (2002) · Expert Opinion on Biological Therapy

Heat shock proteins researchUbiquitin and proteasome pathways

Cited by 531

The Hsp90 molecular chaperone: an open and shut case for treatment

Pearl, L. H., Prodromou, C., & Workman, P. (2008) · Biochemical Journal

Heat shock proteins researchUbiquitin and proteasome pathways

Cited by 447

Inhibitors of cyclin-dependent kinases as cancer therapeutics.

Whittaker, S. R., Mallinger, A., Workman, P., & Clarke, P. A. (2017) · Pharmacology & Therapeutics

Advanced Breast Cancer TherapiesCancer-related Molecular Pathways

Cited by 384

Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

Powers, M. V., Clarke, P. A., & Workman, P. (2008) · Cancer Cell

Heat shock proteins researchCell death mechanisms and regulation

Cited by 307

A systematic review with meta-analysis of the role of anxiety and depression in irritable bowel syndrome onset

Sibelli, A., Chalder, T., Everitt, H., Workman, P., Windgassen, S., & Moss-Morris, R. (2016) · Psychological Medicine

Gastrointestinal motility and disordersPsychosomatic Disorders and Their Treatments

Cited by 196

Altered states: selectively drugging the Hsp90 cancer chaperone

Workman, P. (2004) · Trends in Molecular Medicine

Heat shock proteins researchUbiquitin and proteasome pathways

Cited by 195

Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis

Griffiths, G. J., Koh, M. Y., Brunton, V. G., Cawthorne, C., Reeves, N. A., Greaves, M., Tilby, M. J., Pearson, D. G., Ottley, C. J., Workman, P., et al. (2004) · Journal of Biological Chemistry

Cell death mechanisms and regulationCancer Mechanisms and Therapy

Cited by 60

Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stress

Zhang, L., Fok, J. J. L., Mirabella, F., Aronson, L. I., Fryer, R. A., Workman, P., Morgan, G. J., & Davies, F. E. (2013) · Cancer Letters

Heat shock proteins researchMultiple Myeloma Research and Treatments

Cited by 32

Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches

Darby, J. F., Vidler, L. R., Simpson, P. J., Al-Lazikani, B., Matthews, S. J., Sharp, S. Y., Pearl, L. H., Hoelder, S., & Workman, P. (2020) · Scientific Reports

Heat shock proteins researchProtein Structure and Dynamics

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