The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice
Open accessAbstract
Reprogramming of pancreatic exocrine cells into cells resembling beta cells may provide a strategy for treating diabetes. Here we show that transient administration of epidermal growth factor and ciliary neurotrophic factor to adult mice with chronic hyperglycemia efficiently stimulates the conversion of terminally differentiated acinar cells to beta-like cells. Newly generated beta-like cells are epigenetically reprogrammed, functional and glucose responsive, and they reinstate normal glycemic control for up to 248 d. The regenerative process depends on Stat3 signaling and requires a threshold number of Neurogenin 3 (Ngn3)-expressing acinar cells. In contrast to previous work demonstrating in vivo conversion of acinar cells to beta-like cells by viral delivery of exogenous transcription factors, our approach achieves acinar-to-beta-cell reprogramming through transient cytokine exposure rather than genetic modification.
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Cites
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
Self-citationConversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
Thorel, F., Népote, V., Avril, I., Kohno, K., Desgraz, R., Chera, S., & Herrera, P. L. (2010) · Nature · doi:10.1038/nature08894 · Cited by 1,136
Recovery from diabetes in mice by β cell regeneration
Nir, T., Melton, D. A., & Dor, Y. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32959 · Cited by 595
Self-citationBridging the regeneration gap: Genetic insights from diverse animal models
Alvarado, A. S., & Tsonis, P. A. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1923 · Cited by 467
Means, A. L., Meszoely, I. M., Suzuki, K., Miyamoto, Y., Rustgi, A. K., Coffey, R. J., Wright, C. V. E., Stoffers, D. A., & Leach, S. D. (2005) · Development · doi:10.1242/dev.01925 · Cited by 344
Self-citationPreexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration
Desai, B. M., Oliver-Krasinski, J., De Leon, D. D., Farzad, C., Hong, N., Leach, S. D., & Stoffers, D. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29988 · Cited by 303
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Cited by
Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style
Merrell, A. J., & Stanger, B. Z. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.24 · Cited by 369
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
Cheng, C.-W., Villani, V., Buono, R., Wei, M., Kumar, S., Yilmaz, O. H., Cohen, P., Sneddon, J. B., Perin, L., & Longo, V. D. (2017) · Cell · doi:10.1016/j.cell.2017.01.040 · Cited by 331
Benner, C., van der Meulen, T., Cacéres, E., Tigyi, K., Donaldson, C. J., & Huising, M. O. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-620 · Cited by 302
The JAK / STAT pathway in obesity and diabetes
Gurzov, E. N., Stanley, W. J., Pappas, E. G., Thomas, H. E., & Gough, D. J. (2016) · The FEBS Journal · doi:10.1111/febs.13709 · Cited by 249
Regeneration and Repair of the Exocrine Pancreas
Murtaugh, L. C., & Keefe, M. D. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071727 · Cited by 197
Metadata
- Authors
- Baeyens, L., Lemper, M., Leuckx, G., De Groef, S., Bonfanti, P., Stangé, G., Shemer, R., Nord, C., Scheel, D. W., Pan, F. C., Ahlgren, U., Gu, G., Stoffers, D. A., Dor, Y., Ferrer, J., Gradwohl, G., Wright, C. V. E., Van de Casteele, M., German, M. S., Bouwens, L., & Heimberg, H.
- Venue
- Nature Biotechnology
- Published
- 2013-11-17
- Volume
- 32
- Issue
- 1
- Pages
- 76-83
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2075712485
- Cited by
- 173
- References
- 6
- FWCI
- 29.04
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- green
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- The paper
- Baeyens, L., Lemper, M., Leuckx, G., De Groef, S., Bonfanti, P., Stangé, G., Shemer, R., Nord, C., Scheel, D. W., Pan, F. C., Ahlgren, U., Gu, G., Stoffers, D. A., Dor, Y., Ferrer, J., Gradwohl, G., Wright, C. V. E., Van de Casteele, M., German, M. S., . . . Heimberg, H. (2014). Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nature Biotechnology. https://doi.org/10.1038/nbt.2747
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
