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The DOI matches its Crossref record, with a small difference in title or year; 11 of the 11 references it cites were found in a registry or an index.

The JAK / STAT pathway in obesity and diabetes

Gurzov, Esteban N., Stanley, William J., Pappas, Evan G., Thomas, Helen E., Gough, Daniel J.·2016·The FEBS Journal
DOI 10.1111/febs.13709
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Abstract

Diabetes mellitus are complex, multi‐organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK / STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK / STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK / STAT pathway in treatment of obesity and diabetes.

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  • JAK/STAT3 signaling is also regulated by leptin, providing a link to other aspects of the metabolic syndrome.

    “Notably, JAK/STAT3 signaling is also regulated by leptin, providing a link to other aspects of the metabolic syndrome.”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [97]

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Metadata

Authors
Gurzov, E. N., Stanley, W. J., Pappas, E. G., Thomas, H. E., & Gough, D. J.
Affiliations
  • St Vincent's Institute of Medical Research Fitzroy Australia
  • Hudson Institute of Medical Research Clayton Australia
Venue
The FEBS Journal
Publisher
Wiley
Published
2016-04
Volume
283
Issue
16
Pages
3002-3015
ISSN
  • 1742-464X
  • 1742-4658
DOI
10.1111/febs.13709
Cited by
249
References
11
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
  • Juvenile Diabetes Research Foundation
  • National Health and Medical Research Council (GNT1071350, GNT1024929, GNT1042735)
  • State Government of Victoria

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