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Single-molecule site-specific detection of protein phosphorylation with a nanopore
Open accessAbstract
We demonstrate single-molecule, site-specific detection of protein phosphorylation with protein nanopore technology. A model protein, thioredoxin, was phosphorylated at two adjacent sites. Analysis of the ionic current amplitude and noise, as the protein unfolds and moves through an α-hemolysin pore, enables the distinction between unphosphorylated, monophosphorylated and diphosphorylated variants. Our results provide a step toward nanopore proteomics.
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Prabakaran, S., Lippens, G., Steen, H., & Gunawardena, J. (2012) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1185 · Cited by 335
Cited by
Nanopore-based technologies beyond DNA sequencing
Ying, Y.-L., Hu, Z.-L., Zhang, S., Qing, Y., Fragasso, A., Maglia, G., Meller, A., Bayley, H., Dekker, C., & Long, Y.-T. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01193-2 · Cited by 538
Self-citationSingle-cell multiomics: multiple measurements from single cells
Macaulay, I. C., Ponting, C. P., & Voet, T. (2017) · Trends in Genetics · doi:10.1016/j.tig.2016.12.003 · Cited by 451
Digitally encoded DNA nanostructures for multiplexed, single-molecule protein sensing with nanopores
Bell, N. A. W., & Keyser, U. F. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.50 · Cited by 345
Single-molecule protein sensing in a nanopore: a tutorial
Varongchayakul, N., Song, J., Meller, A., & Grinstaff, M. W. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00106e · Cited by 282
Metadata
- Authors
- Rosen, C. B., Rodriguez-Larrea, D., & Bayley, H.
- Venue
- Nature Biotechnology
- Published
- 2014-01-19
- Volume
- 32
- Issue
- 2
- Pages
- 179-181
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2038218701
- Cited by
- 270
- References
- 1
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Rosen, C. B., Rodriguez-Larrea, D., & Bayley, H. (2014). Single-molecule site-specific detection of protein phosphorylation with a nanopore. Nature Biotechnology. https://doi.org/10.1038/nbt.2799
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
