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Generation of the epicardial lineage from human pluripotent stem cells
Open accessAbstract
The epicardium supports cardiomyocyte proliferation early in development and provides fibroblasts and vascular smooth muscle cells to the developing heart. The epicardium has been shown to play an important role during tissue remodeling after cardiac injury, making access to this cell lineage necessary for the study of regenerative medicine. Here we describe the generation of epicardial lineage cells from human pluripotent stem cells by stage-specific activation of the BMP and WNT signaling pathways. These cells display morphological characteristics and express markers of the epicardial lineage, including the transcription factors WT1 and TBX18 and the retinoic acid-producing enzyme ALDH1A2. When induced to undergo epithelial-to-mesenchymal transition, the cells give rise to populations that display characteristics of the fibroblast and vascular smooth muscle lineages. These findings identify BMP and WNT as key regulators of the epicardial lineage in vitro and provide a model for investigating epicardial function in human development and disease.
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“The derivation of CMs can be achieved by controlling the expression of Wnt and BMP at specific times from the mesoderm stage [397,398].”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [397]
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“We believe enhanced differentiation at lower CHIR concentrations can be attributed to endogenous morphogen production due to the self-assembling conditions provided28–32.”
From Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease (2021) · cites this paper as [28]
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Lian, X., Hsiao, C., Wilson, G., Zhu, K., Hazeltine, L. B., Azarin, S. M., Raval, K. K., Zhang, J., Kamp, T. J., & Palecek, S. P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200250109 · Cited by 1,717
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population
Yang, L., Soonpaa, M. H., Adler, E. D., Roepke, T. K., Kattman, S. J., Kennedy, M., Henckaerts, E., Bonham, K., Abbott, G. W., Linden, R. M., et al. (2008) · Nature · doi:10.1038/nature06894 · Cited by 1,389
Self-citationJonasson, L., Holm, J., Skalli, O., Bondjers, G., & Hansson, G. K. (1986) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.6.2.131 · Cited by 1,329
Kattman, S. J., Witty, A. D., Gagliardi, M., Dubois, N. C., Niapour, M., Hotta, A., Ellis, J., & Keller, G. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2010.12.008 · Cited by 1,159
Self-citationDorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
Yu, P. B., Hong, C. C., Sachidanandan, C., Babitt, J. L., Deng, D. Y., Hoyng, S. A., Lin, H. Y.-F., Bloch, K. D., & Peterson, R. T. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.54 · Cited by 1,059
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
Zhou, B., Ma, Q., Rajagopal, S., Wu, S. M., Domian, I., Rivera-Feliciano, J., Jiang, D., von Gise, A., Ikeda, S., Chien, K. R., et al. (2008) · Nature · doi:10.1038/nature07060 · Cited by 1,019
Lepilina, A., Coon, A. N., Kikuchi, K., Holdway, J. E., Roberts, R. W., Burns, C. G., & Poss, K. D. (2006) · Cell · doi:10.1016/j.cell.2006.08.052 · Cited by 848
A myocardial lineage derives from Tbx18 epicardial cells
Cai, C., Martin, J., Sun, Y., Cui, L., Wang, L., Ouyang, K., Yang, L., Bu, L., Liang, X., Zhang, X., et al. (2008) · Nature · doi:10.1038/nature06969 · Cited by 783
De novo cardiomyocytes from within the activated adult heart after injury
Smart, N., Bollini, S., Dubé, K. N., Vieira, J. M., Zhou, B., Davidson, S. M., Yellon, D. M., Riegler, J., Price, A. N., Lythgoe, M. F., et al. (2011) · Nature · doi:10.1038/nature10188 · Cited by 640
Ueno, S., Weidinger, G., Osugi, T., Kohn, A. D., Golob, J. L., Pabon, L., Reinecke, H., Moon, R. T., & Murry, C. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702859104 · Cited by 613
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Wong, D., Martinez, J., & Quijada, P. J. (2024) · Circulation Research · doi:10.1161/circresaha.124.321567 · Cited by 17
Floy, M. E., Givens, S. E., Rubio, O., Mateyka, T. D., Kerr, C. M., Steinberg, A. B., Silva, A. C., Zhang, J., Mei, Y., Ogle, B. M., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202100523r · Cited by 20
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Wu, L., Du, J., Jing, X., Yan, Y., Deng, S., Hao, Z., & She, Q. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7243 · Cited by 13
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Min, K.-D., Asakura, M., Shirai, M., Yamazaki, S., Ito, S., Fu, H. Y., Asanuma, H., Asano, Y., Minamino, T., Takashima, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-02390-0 · Cited by 12
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Rao, K., & Spees, J. L. (2017) · Current Molecular Biology Reports · doi:10.1007/s40610-017-0066-6 · Cited by 9
Ikeda, N., Nakazawa, N., Kurata, Y., Yaura, H., Taufiq, F., Minato, H., Yoshida, A., Ninomiya, H., NAKAYAMA, Y., Kuwabara, M., et al. (2017) · Biomedical Research · doi:10.2220/biomedres.38.229 · Cited by 9
Wang, F., Zou, X., Zheng, H., Kong, T., & Pei, D. (2025) · Cell & Bioscience · doi:10.1186/s13578-024-01339-w · Cited by 8
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Qin, Q., Wang, J., Yan, Y., Jing, X., Du, J., Deng, S., Wu, L., Liu, Y., & She, Q. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.122 · Cited by 6
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Duffey, O. J., & Smart, N. (2017) · Global Cardiology Science and Practice · doi:10.21542/gcsp.2016.28 · Cited by 5
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Wang, M., Zhao, J., Tian, L., Cao, G., Chen, Y., Tan, J., Xu, J., Liao, S., Wu, H., Zhang, J., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.157811 · Cited by 2
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Rosner, M., & Hengstschläger, M. (2021) · Stem Cells · doi:10.1002/stem.3441 · Cited by 1
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Wagner, K. T., Bannerman, D., Wu, Q., Pascual‐Gil, S., Fernandes, I. M., Vargas, L. F. J., Yan, S., Khosravi, R., Okhovatian, S., Abdo, D., et al. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103236 · Cited by 1
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Tomizawa, M., Shinozaki, F., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., & Ishige, N. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4314 · Cited by 1
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Hou, X., Ma, S., Fan, W., Li, F., Xu, M., Yang, C., Liu, F., Yan, Y., 万居易, Lan, F., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19582156
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Liu, F., Fang, Y., Hou, X., Yan, Y., Xiao, H., Zuo, D., Wen, J., Wang, L., Zhou, Z., Dang, X., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12667757
Liu, F., Fang, Y., Hou, X., Yan, Y., Xiao, H., Zuo, D., Wen, J., Wang, L., Zhou, Z., Dang, X., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12667778
Hou, X., Ma, S., Fan, W., Li, F., Xu, M., Yang, C., Liu, F., Yan, Y., 万居易, Lan, F., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19582153
Liu, F., Fang, Y., Hou, X., Yan, Y., Xiao, H., Zuo, D., Wen, J., Wang, L., Zhou, Z., Dang, X., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12667766
Liu, F., Fang, Y., Hou, X., Yan, Y., Xiao, H., Zuo, D., Wen, J., Wang, L., Zhou, Z., Dang, X., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12667769
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BindingDB Entry 50006478: Medicinal Chemistry Approaches to Heart Regeneration.
BindingDB (2020) · UC San Diego · doi:10.7270/q2125wns
Metadata
- Authors
- Witty, A. D., Mihic, A., Tam, R. Y., Fisher, S. A., Mikryukov, A., Shoichet, M. S., Li, R.-K., Kattman, S. J., & Keller, G.
- Affiliations
- University Health Network (CA)
- University of Toronto (CA)
- Corresponding author
- Keller, Gordon
- Venue
- Nature Biotechnology
- Published
- 2014-09-21
- Volume
- 32
- Issue
- 10
- Pages
- 1026-1035
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- PMC
- PMC4192149
- OpenAlex
- W1969193847
- Cited by
- 180
- References
- 49
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 11 · 2023: 12 · 2022: 10 · 2021: 20 · 2020: 20 · 2019: 23 · 2018: 13 · 2017: 19 · 2016: 21 · 2015: 16 · 2014: 1
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institutes of Health Research (MOP119507, MOP106538, 127793_1, MOP-84524)
- National Heart, Lung, and Blood Institute (U01HL100405)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- epicardium, human pluripotent stem cells, BMP signaling, Wnt signaling, WT1, Tbx18, ALDH1A2, epithelial-mesenchymal transition, cardiac fibroblasts, vascular smooth muscle cells, cardiac regeneration, heart development
- MeSH terms
- Aldehyde Dehydrogenase, Animals, Humans, Pericardium, Cell Lineage, Myocytes, Cardiac, Pluripotent Stem Cells, Mice, Bone Morphogenetic Protein 4, Epithelial-Mesenchymal Transition, Wnt Signaling Pathway
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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