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Cited by 873

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

Comparative analysis of the complete genome sequence of the plant growth–promoting bacterium Bacillus amyloliquefaciens FZB42

Open access
Chen, Xiao Hua, Koumoutsi, Alexandra, Scholz, Romy, Eisenreich, Andreas, Schneider, Kathrin, Heinemeyer, Isabelle, Morgenstern, Burkhard, Voss, Björn, Hess, Wolfgang R, Reva, Oleg, Junge, Helmut, Voigt, Birgit, Jungblut, Peter R, Vater, Joachim, Süssmuth, Roderich, Liesegang, Heiko, Strittmatter, Axel, Gottschalk, Gerhard, Borriss, Rainer·2007·Nature Biotechnology

Abstract

Bacillus amyloliquefaciens FZB42 is a Gram-positive, plant-associated bacterium, which stimulates plant growth and produces secondary metabolites that suppress soil-borne plant pathogens. Its 3,918-kb genome, containing an estimated 3,693 protein-coding sequences, lacks extended phage insertions, which occur ubiquitously in the closely related Bacillus subtilis 168 genome. The B. amyloliquefaciens FZB42 genome reveals an unexpected potential to produce secondary metabolites, including the polyketides bacillaene and difficidin. More than 8.5% of the genome is devoted to synthesizing antibiotics and siderophores by pathways not involving ribosomes. Besides five gene clusters, known from B. subtilis to mediate nonribosomal synthesis of secondary metabolites, we identified four giant gene clusters absent in B. subtilis 168. The pks2 gene cluster encodes the components to synthesize the macrolactin core skeleton.

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Crossref · 10.1038/nbt1325

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Metadata

Authors
Chen, X. H., Koumoutsi, A., Scholz, R., Eisenreich, A., Schneider, K., Heinemeyer, I., Morgenstern, B., Voss, B., Hess, W. R., Reva, O., Junge, H., Voigt, B., Jungblut, P. R., Vater, J., Süssmuth, R., Liesegang, H., Strittmatter, A., Gottschalk, G., & Borriss, R.
Venue
Nature Biotechnology
Published
2007-08-19
Volume
25
Issue
9
Pages
1007-1014
ISSN
  • 0733-222X (ISSN-L)
  • 1087-0156
  • 1546-1696
OpenAlex
W2160440240
Cited by
873
References
70
FWCI
11.36
Type
journal article
Language
en
Open access
hybrid

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The paper
Chen, X. H., Koumoutsi, A., Scholz, R., Eisenreich, A., Schneider, K., Heinemeyer, I., Morgenstern, B., Voss, B., Hess, W. R., Reva, O., Junge, H., Voigt, B., Jungblut, P. R., Vater, J., Süssmuth, R., Liesegang, H., Strittmatter, A., Gottschalk, G., & Borriss, R. (2007). Comparative analysis of the complete genome sequence of the plant growth–promoting bacterium Bacillus amyloliquefaciens FZB42. Nature Biotechnology. https://doi.org/10.1038/nbt1325

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.