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Complete genome sequence of the myxobacterium Sorangium cellulosum
Open accessAbstract
The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sorangium strain S. cellulosum So ce56, which produces several natural products and has morphological and physiological properties typical of the genus. The circular genome, comprising 13,033,779 base pairs, is the largest bacterial genome sequenced to date. No global synteny with the genome of Myxococcus xanthus is apparent, revealing an unanticipated level of divergence between these myxobacteria. A large percentage of the genome is devoted to regulation, particularly post-translational phosphorylation, which probably supports the strain's complex, social lifestyle. This regulatory network includes the highest number of eukaryotic protein kinase-like kinases discovered in any organism. Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry.
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Boyle, E. I., Weng, S., Gollub, J., Jin, H., Botstein, D., Cherry, J. M., & Sherlock, G. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth456 · Cited by 2,067
Protein length in eukaryotic and prokaryotic proteomes
Brocchieri, L. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki615 · Cited by 414
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“Prokaryotes have highly variable gene repertoires, varying from just over 100 genes to nearly 10000 [1,2].”
BackgroundMaia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401
Comprehensive benchmarking and ensemble approaches for metagenomic classifiers
McIntyre, A. B. R., Ounit, R., Afshinnekoo, E., Prill, R. J., Hénaff, E., Alexander, N., Minot, S. S., Danko, D., Foox, J., Ahsanuddin, S., et al. (2017) · Genome Biology · doi:10.1186/s13059-017-1299-7 · Cited by 342
Myxobacterial secondary metabolites: bioactivities and modes-of-action
Weissman, K. J., & Müller, R. (2010) · Natural Product Reports · doi:10.1039/c001260m · Cited by 310
Self-citationGenomes in turmoil: quantification of genome dynamics in prokaryote supergenomes
Puigbò, P., Lobkovsky, A. E., Kristensen, D. M., Wolf, Y. I., & Koonin, E. V. (2014) · BMC Biology · doi:10.1186/s12915-014-0066-4 · Cited by 232
Metadata
- Authors
- Schneiker, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M. O., Bartels, D., Bekel, T., Beyer, S., Bode, E., Bode, H. B., Bolten, C. J., Choudhuri, J. V., Doss, S., Elnakady, Y. A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., Gross, F., Jelsbak, L., Jelsbak, L., Kalinowski, J., Kegler, C., Knauber, T., Konietzny, S., Kopp, M., Krause, L., Krug, D., Linke, B., Mahmud, T., Martinez-Arias, R., McHardy, A. C., Merai, M., Meyer, F., Mormann, S., Muñoz-Dorado, J., Perez, J., Pradella, S., Rachid, S., Raddatz, G., Rosenau, F., Rückert, C., Sasse, F., Scharfe, M., Schuster, S. C., Suen, G., Treuner-Lange, A., Velicer, G. J., Vorhölter, F.-J., Weissman, K. J., Welch, R. D., Wenzel, S. C., Whitworth, D. E., Wilhelm, S., Wittmann, C., Blöcker, H., Pühler, A., & Müller, R.
- Venue
- Nature Biotechnology
- Published
- 2007-10-28
- Volume
- 25
- Issue
- 11
- Pages
- 1281-1289
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2056743521
- Cited by
- 425
- References
- 2
- FWCI
- 21.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Schneiker, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M. O., Bartels, D., Bekel, T., Beyer, S., Bode, E., Bode, H. B., Bolten, C. J., Choudhuri, J. V., Doss, S., Elnakady, Y. A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., . . . Müller, R. (2007). Complete genome sequence of the myxobacterium Sorangium cellulosum. Nature Biotechnology. https://doi.org/10.1038/nbt1354
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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