The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The genome sequence of the extreme thermophile Thermus thermophilus
Open accessAbstract
Thermus thermophilus HB27 is an extremely thermophilic, halotolerant bacterium, which was originally isolated from a natural thermal environment in Japan. This organism has considerable biotechnological potential; many thermostable proteins isolated from members of the genus Thermus are indispensable in research and in industrial applications. We present here the complete genome sequence of T. thermophilus HB27, the first for the genus Thermus. The genome consists of a 1,894,877 base pair chromosome and a 232,605 base pair megaplasmid, designated pTT27. The 2,218 identified putative genes were compared to those of the closest relative sequenced so far, the mesophilic bacterium Deinococcus radiodurans. Both organisms share a similar set of proteins, although their genomes lack extensive synteny. Many new genes of potential interest for biotechnological applications were found in T. thermophilus HB27. Candidates include various proteases and key enzymes of other fundamental biological processes such as DNA replication, DNA repair and RNA maturation.
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Cited by
Oxidative Stress Resistance in Deinococcus radiodurans
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Modularity of membrane-bound charge-translocating protein complexes
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Metadata
- Authors
- Henne, A., Brüggemann, H., Raasch, C., Wiezer, A., Hartsch, T., Liesegang, H., Johann, A., Lienard, T., Gohl, O., Martinez-Arias, R., Jacobi, C., Starkuviene, V., Schlenczeck, S., Dencker, S., Huber, R., Klenk, H.-P., Kramer, W., Merkl, R., Gottschalk, G., & Fritz, H.-J.
- Venue
- Nature Biotechnology
- Published
- 2004-04-04
- Volume
- 22
- Issue
- 5
- Pages
- 547-553
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2064462284
- Cited by
- 384
- References
- 39
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Henne, A., Brüggemann, H., Raasch, C., Wiezer, A., Hartsch, T., Liesegang, H., Johann, A., Lienard, T., Gohl, O., Martinez-Arias, R., Jacobi, C., Starkuviene, V., Schlenczeck, S., Dencker, S., Huber, R., Klenk, H.-P., Kramer, W., Merkl, R., Gottschalk, G., & Fritz, H.-J. (2004). The genome sequence of the extreme thermophile Thermus thermophilus. Nature Biotechnology. https://doi.org/10.1038/nbt956
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