The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Harnessing the potential of induced pluripotent stem cells for regenerative medicine
Open accessAbstract
The discovery of methods to convert somatic cells into induced pluripotent stem cells (iPSCs) through expression of a small combination of transcription factors has raised the possibility of producing custom-tailored cells for the study and treatment of numerous diseases. Indeed, iPSCs have already been derived from patients suffering from a large variety of disorders. Here we review recent progress that has been made in establishing iPSC-based disease models, discuss associated technical and biological challenges, and highlight possible solutions to overcome these barriers. We believe that a better understanding of the molecular basis of pluripotency, cellular reprogramming and lineage-specific differentiation of iPSCs is necessary for progress in regenerative medicine.
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Cited by
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.
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Metadata
- Authors
- Wu, S. M., & Hochedlinger, K.
- Venue
- Nature Cell Biology
- Published
- 2011-05
- Volume
- 13
- Issue
- 5
- Pages
- 497-505
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2092780119
- Cited by
- 506
- References
- 18
- FWCI
- 26.92
- Type
- journal article
- Language
- en
- Open access
- green
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