Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 866

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis

Liang, Jiyong, Shao, Shan H., Xu, Zhi-Xiang, Hennessy, Bryan, Ding, Zhiyong, Larrea, Michelle, Kondo, Seiji, Dumont, Dan J., Gutterman, Jordan U., Walker, Cheryl L., Slingerland, Joyce M., Mills, Gordon B.·2007·Nature Cell Biology

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/ncb1537

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 5 references

Research works printed but not linked: 30

  1. Pardee, A. A restriction point for control of normal animal cell proliferation. Proc. Natl Acad. Sci. USA 71, 1286–1290 (1974). · DOI · Paper page
  2. Hay, N. & Sonenberg, N. Upstream and downstream of mTOR. Genes Dev. 18, 1926–1945 (2004). · DOI · Paper page
  3. Wilson, W. & Roach, P. J. Nutrient-regulated protein kinases in budding yeast. Cell 111, 155–158 (2002). · DOI
  4. Inoki, K., Zhu, T. & Guan, K. L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577–590 (2003). · DOI · Paper page
  5. Hardie, D. The AMP-activated protein kinase pathway – new players upstream and downstream. J. Cell Sci. 117, 5479–5487 (2004). · DOI · Paper page
  6. Jones, R. et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol. Cell 18, 283–293 (2005). · DOI · Paper page
  7. Kondo, Y., Kanzawa, T., Sawaya, R. & Kondo, S. The role of autophagy in cancer development and response to therapy. Nature Rev. Cancer 5, 726–734 (2005). · DOI · Paper page
  8. Lum, J., DeBerardinis, R. J. & Thompson, C.B. Autophagy in metazoans: cell survival in the land of plenty. Nature Rev. Mol. Cell Biol. 6, 439–448 (2005). · DOI · Paper page
  9. Reggiori, F. & Klionsky, D. J. Autophagosomes: biogenesis from scratch? Curr. Opin. Cell Biol. 17, 415–422 (2005). · DOI · Paper page
  10. Massagué, J. G1 cell-cycle control and cancer. Nature 432, 298–306 (2004). · DOI · Paper page
  11. Wu, F. et al. Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity. Cancer Res. 66, 2162–2172 (2006). · DOI
  12. Slingerland, J. & Pagano, M. Regulation of the cdk inhibitor p27 and its deregulation in cancer. J. Cell Physiol. 183, 10–17 (2000). · DOI · Paper page
  13. Ishida, N., Kitagawa, M., Hatakeyama, S. & Nakayama, K. Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability. J. Biol. Chem. 275, 25146–25154 (2000). · DOI
  14. Kossatz, U. et al. C-terminal phosphorylation controls the stability and function of p27kip1. EMBO J. 25, 5159–5170 (2006). · DOI
  15. Viglietto, G., Motti, M.L. & Fusco, A. Understanding p27Kip1 deregulation in cancer: down-regulation or mislocalization. Cell Cycle 1, 394–400 (2002). · doi:10.4161/cc.1.6.263
  16. Fujita, N., Sato, S. & Tsuruo, T. Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14–3-3 and cytoplasmic localization. J. Biol. Chem. 278, 49254–49260 (2003). · DOI · Paper page
  17. Motti, M. et al. Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization. Am. J. Pathol. 166, 737–749 (2005). · DOI
  18. Biederbick, A., Kern, H. F. & Elsasser, H.P. Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur. J. Cell Biol. 66, 3–14 (1995).
  19. Takeuchi, H. et al. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res. 65, 3336–3346 (2005). · DOI · Paper page
  20. Eskelinen, E. et al. Inhibition of autophagy in mitotic animal cells. Traffic 3, 878–893 (2002). · DOI
  21. Veneault-Fourrey, C., Barooah, M., Egan, M., Wakley, G. & Talbot, N. J. Autophagic fungal cell death is necessary for infection by the rice blast fungus. Science 312, 580–580 (2006). · DOI · Paper page
  22. Michell, B. et al. Isoform-specific purification and substrate specificity of the 5'-AMP-activated protein kinase. Biol. Chem. 271, 28445–28450 (1996). · DOI
  23. Motti, M., De Marco, C., Califano, D., Fusco, A. & Viglietto, G. Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1 in breast cancer. Cell Cycle 3, 1074–1080 (2004). · DOI
  24. Kiyokawa, H. et al. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell 85, 721–732 (1996). · DOI · Paper page
  25. Levkau, B. et al. Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Mol. Cell 1, 553–563 (1998). · DOI · Paper page
  26. Muraoka, R. et al. ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells. Mol. Cell Biol. 22, 2204–2219 (2002). · DOI
  27. Gao, H. et al. A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis. Proc. Natl Acad. Sci. USA 104, 17204–17209 (2004). · DOI
  28. Liang, J. et al. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nature Med. 8, 1153–1160 (2002). · DOI · Paper page
  29. Lu, Y. et al. Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades. J. Biol. Chem. 278, 40057–40066 (2003). · DOI · Paper page
  30. Sheehan, K. et al. Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma. Mol. Cell. Proteomics 4, 346–355 (2005). · DOI · Paper page

Cited by

See all 866

Metadata

Authors
Liang, J., Shao, S. H., Xu, Z.-X., Hennessy, B., Ding, Z., Larrea, M., Kondo, S., Dumont, D. J., Gutterman, J. U., Walker, C. L., Slingerland, J. M., & Mills, G. B.
Venue
Nature Cell Biology
Published
2007-01-21
Volume
9
Issue
2
Pages
218-224
ISSN
  • 1465-7392 (ISSN-L)
  • 1476-4679
OpenAlex
W2070224555
Cited by
866
References
5
FWCI
36.85
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis. https://app.cochat.ai/papers/10.1038/ncb1537
The paper
Liang, J., Shao, S. H., Xu, Z.-X., Hennessy, B., Ding, Z., Larrea, M., Kondo, S., Dumont, D. J., Gutterman, J. U., Walker, C. L., Slingerland, J. M., & Mills, G. B. (2007). The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis. Nature Cell Biology. https://doi.org/10.1038/ncb1537

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.