Cited by 209NF-κB Signaling PathwaysEstrogen and related hormone effectsSignaling Pathways in Disease

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Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2

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Wang, Xiaobo, Belguise, Karine, Kersual, Nathalie, Kirsch, Kathrin H., Mineva, Nora D., Galtier, Florence, Chalbos, Dany, Sonenshein, Gail E.·2007·Nature Cell Biology

DOI 10.1038/ncb1559PMC PMC2394707

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Abstract

Aberrant constitutive expression of c-Rel, p65 and p50 NF-kappaB subunits has been reported in over 90% of breast cancers. Recently, we characterized a de novo RelB NF-kappaB subunit synthesis pathway, induced by the cytomegalovirus (CMV) IE1 protein, in which binding of p50-p65 NF-kappaB and c-Jun-Fra-2 AP-1 complexes to the RELB promoter work in synergy to potently activate transcription. Although RelB complexes were observed in mouse mammary tumours induced by either ectopic c-Rel expression or carcinogen exposure, little is known about RelB in human breast disease. Here, we demonstrate constitutive de novo RelB synthesis is selectively active in invasive oestrogen receptor alpha (ERalpha)-negative breast cancer cells. ERalpha signalling reduced levels of functional NF-kappaB and Fra-2 AP-1 and inhibited de novo RelB synthesis, leading to an inverse correlation between RELB and ERalpha gene expression in human breast cancer tissues and cell lines. Induction of Bcl-2 by RelB promoted the more invasive phenotype of ERalpha-negative cancer cells. Thus, inhibition of de novo RelB synthesis represents a new mechanism whereby ERalpha controls epithelial to mesenchymal transition (EMT).

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Authors: Wang, X., Belguise, K., Kersual, N., Kirsch, K. H., Mineva, N. D., Galtier, F., Chalbos, D., & Sonenshein, G. E.
Affiliations: Boston University (US)
Inserm (FR)
Corresponding author: Sonenshein, Gail E.
ORCID: Wang, Xiaobo
Belguise, Karine
Kirsch, Kathrin H.
Mineva, Nora D.
Galtier, Florence
Chalbos, Dany
Sonenshein, Gail E.
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2007-03-18
Volume: 9
Issue: 4
Pages: 470-478
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/ncb1559
PMC: PMC2394707
OpenAlex: W2112528220
Cited by: 209
References: 37
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 7 · 2018: 10 · 2017: 9 · 2016: 12 · 2015: 13 · 2014: 11 · 2013: 18 · 2012: 22
FWCI: 7.19
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion, other-oa)
Funders: National Cancer Institute (R01CA036355, CA 36355)
National Institute of Environmental Health Sciences (ES 11624, P01ES011624)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: RelB, NF-κB, estrogen receptor alpha, breast cancer, tumor invasion, epithelial-mesenchymal transition, Bcl-2, c-Rel, transcriptional regulation
MeSH terms: Animals, Breast Neoplasms, Cell Movement, Cell Transformation, Neoplastic, Estrogens, Female, Humans, Microscopy, Fluorescence, Phenotype, Protein Binding, Immunoblotting, Blotting, Northern, Signal Transduction, Gene Expression Regulation, Neoplastic, NF-kappa B, Proto-Oncogene Proteins c-bcl-2, Reverse Transcriptase Polymerase Chain Reaction, Electrophoretic Mobility Shift Assay, Cell Line, Tumor, Estrogen Receptor alpha, Mice, Transcription Factor RelB, Fos-Related Antigen-2

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Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2

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