The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase

Hiratsuka, Sachie, Watanabe, Akira, Sakurai, Yoshiko, Akashi-Takamura, Sachiko, Ishibashi, Sachie, Miyake, Kensuke, Shibuya, Masabumi, Akira, Shizuo +2 more·2008·Nature Cell Biology

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    Surya Kumari Vadrevu, Sharad Sharma, Navin K. Chintala, Jalpa Patel, Magdalena Karbowniczek, Maciej M. Markiewski · 2016 · Journal of Visualized Experiments
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  5. Biological Characterization of Commercial Recombinantly Expressed Immunomodulating Proteins Contaminated with Bacterial Products in the Year 2020: The SAA3 Case
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    Takaomi Hagi, Yukinori Kurokawa, Noboru Kobayashi, Tsuyoshi Takahashi, Takuro Saito, Kotaro Yamashita, Koji Tanaka, Tomoki Makino, Makoto Yamasaki, Kiyokazu Nakajima et al. · 2021 · Scientific Reports
  7. Pathobiology of Osteolytic and Osteoblastic Bone Metastases
    Antonella Chiechi, Theresa A. Guise · 2015 · Springer eBooks
  8. Preparing the soil
    Sarah E. Seton-Rogers · 2008 · Nature reviews. Cancer
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  13. The Tumour Microenvironment and Circulating Tumour Cells: A Partnership Driving Metastasis and Glycan-Based Opportunities for Cancer Control
    Andreia Peixoto, Sofia Cotton, Lúcio Lara Santos, José Alexandre Ferreira · 2021 · Advances in experimental medicine and biology
  14. Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression
    Zhuang Chen, Qiming Wang, Jinbo Liu, Wenkang Wang, Weitang Yuan, Yang Liu, Zhenqiang Sun, Chengzeng Wang · 2023 · Genes & Diseases
  15. Tumour-Promoting Stromal Myofibroblasts in Human Carcinomas
    Urszula M. Polanska, Kieran T. Mellody, Akira Orimo · 2010 · Springer eBooks
  16. Premetastatic milieu explained by TLR4 agonist-mediated homeostatic inflammation
    Yoshiro Maru · 2010 · Cellular and Molecular Immunology
  17. PPARδ as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance
    R. Glazer · 2016 · PPAR Research
  18. Neuroplastinβ-mediated upregulation of solute carrier family 22 member 18 antisense (SLC22A18AS) plays a crucial role in the epithelial-mesenchymal transition, leading to lung cancer cells' enhanced motility
    Karolina Bajkowska, I Wayan Sumardika, Nahoko Tomonobu, Youyi Chen, Ken-ichi Yamamoto, Rie Kinoshita, Hitoshi Murata, Ni Luh Gede Yoni Komalasari, Fan Jiang, 明 山内 et al. · 2020 · Biochemistry and Biophysics Reports
  19. Network analysis of icb‐1 gene function in human breast cancer cells
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  20. Myeloid-Derived Suppressor Cells: General Characteristics and Relevance to Clinical Management of Pancreatic Cancer
    Peter S. Goedegebuure · 2011 · Current Cancer Drug Targets
  21. Pathways of Metastasizing Intestinal Cancer Cells Revealed: How Will Fighting Metastases at the Site of Cancer Cell Arrest Affect Drug Development?
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  23. Matrix Metalloproteinases (MMPs) in Cancer Initiation and Progression
    Sanjeev Kumar Maurya, Nitesh Kumar Poddar, Pallavi Tandon, Ajit Kumar Yadav · 2017 · Springer eBooks
  24. S100A8 Expression May Have a Prognostic Value in CCRCC Reflecting TNM Staging and Fuhrman Nuclear Grade
    Hyo Jung An, Hyun Min Koh, Dae Hyun Song · 2019 · Anticancer Research
  25. Exosomes in respiratory disease
    Shamila D. Alipoor, Esmaeil Mortaz · 2019 · Elsevier eBooks
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    Yuichi Kitai · 2022 · YAKUGAKU ZASSHI
  27. Microenvironnement et angiogenèse des métastases hépatiques d’origine colorectale : implications chirurgicales
    Chétana Lim, Clarisse Eveno, Marc D. Pocard · 2013 · Bulletin du Cancer
  28. TLR4-Induced Inflammation Is a Key Promoter of Tumor Growth, Vascularization, and Metastasis
    Sophia Ran, Nihit Bhattarai, Radhika Patel, Lisa D. Volk-Draper · 2019 · IntechOpen eBooks
  29. Targeting nuclear factor‐κ B suppresses the negative effect of T oll‐like receptor 4 signaling on antimetastasis therapy based on targeting αvβ3
    Jianhua Zhu, Ye Yuan, Dong Li, Shengjun Liao, Yuanhong Zhou, Qi Wang, Yu Shu, Bin Yan, Jingjing Wei, Rui Sun et al. · 2012 · Cancer Science
  30. The Temporal Progression of Immune Remodeling During Metastasis
    Christopher S. McGinnis, Zhuang Miao, Nathan Edward Reticker-Flynn, Juliane Winkler, Ansuman T. Satpathy · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  31. S100A8 as a potential therapeutic target for cancer metastasis
    Atsuko Deguchi, Yoshiro Maru · 2024 · Cancer Science
  32. Medical and scientific evidence for the cancer attractor
    Romano Demicheli, William J.M. Hrushesky, Elizabeth Saenger, Elia Mario Biganzoli · 2024 · Academia oncology.
  33. Bone Marrow Niche: Role of Different Cells in Bone Metastasis
    Terhi J. Heino, Jorma A. Määttä · 2018 · Current Molecular Biology Reports
  34. Induction of Serum Amyloid A3 in Mouse Mammary Epithelial Cells Stimulated with Lipopolysaccharide and Lipoteichoic Acid
    Sato Kamiya, Kaori Shimizu, Ayaka Okada, Yasuo Inoshima · 2021 · Animals
  35. Inflammation in tumor progression
    Yoshiro Maru · 2011 · Folia Pharmacologica Japonica
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    Subhash J. Jakhesara, PRAKASH G. KORINGA, Neelam Mustakali Nathani, Chaitanya G. Joshi · 2016 · 3 Biotech
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    Haruka Kawasaki, Tomoaki Murakami, Yassien Badr, Sato Kamiya, Kaori Shimizu, Ayaka Okada, Yasuo Inoshima · 2020 · Experimental Lung Research
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    Parisa Khosravi, Saeid Abroun, Saeid Kaviani, Saman Masoudifar, Homayoun Sarough Farahani · 2023 · PLoS ONE
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    Hiroaki Shime, Misako Matsumoto, Tsukasa Seya · 2015 · Springer eBooks
  42. Improving Response and Outcomes for Patients With Liver-Limited Metastatic Colorectal Cancer
    David James Gallagher, Nancy E. Kemeny · 2010 · Clinical Colorectal Cancer
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    Felipe Osório–Costa, José Barreto Campello Carvalheira · 2013 · Translational gastrointestinal cancer
  44. The Concept of a Preniche for Localization of Future Metastases
    Перельмутер Владимир Михайлович, В. Н. Манских · 2013 · Tumors of the central nervous system
  45. Tumor-Induced Myeloid-Derived Suppressor Cells
    Francesco De Sanctis, Vincenzo Bronte, Stefano Ugel · 2017 · ASM Press eBooks
  46. Tumor-derived S100A14 targeted astrocytes via TLR4 to Recruit myeloid-derived suppressor cells promoting brain metastasis and Curdione reversal effect
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    Eva Källberg, Fredrik Ivars, Tomas Leanderson · 2014 · Scandinavian Journal of Immunology
  49. Mechanisms Underlying Osteolytic and Osteoblastic Bone Metastases
    Gabriela G. Loots, Theresa A. Guise · 2024 · Springer eBooks
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    Fernanda Carolina Ribeiro Dias, Jaciel B. Oliveira, Bruna Santana Silva Pinheiro, Helen Fernanda Marcelino Pacheco, Julia Gonçalves Rodrigues, Jhessyka L. F. Fernandes, Marcos de Lucca Moreira Gomes · 2024 · Interdisciplinary cancer research
  51. Kaplan et al. reply
    Rosandra Natasha Kaplan, Rebecca D. Riba, Stergios Zacharoulis, Anna H. Bramley, Loïc Vincent, Carla Costa, Daniel D. MacDonald, David K. Jin, Koji Shido, Scott A. Kerns et al. · 2009 · Nature
  52. Collateral presentation of antigens as physiological prototype for lymph node metastases
    В. Н. Манских, Перельмутер Владимир Михайлович · 2013 · Biochemistry (Moscow)
  53. The S100A8-serum amyloid A3-LOX-1 cascade in atherosclerotic plaque rupture
    Yating Wang, Danyan Xu · 2015 · International Journal of Cardiology
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    Paola Ferrari, Andrea Nicolini · 2015 · Springer eBooks
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    Ana G. Abril, Vicente Notario · 2019 · Springer eBooks
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  58. S100A8/A9 predicts triple-negative breast cancer response to PIM kinase and PD-1/PD-L1 inhibition
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  59. Tumor resection may abort the antitumor immune response produced from primary foci
    Kun Xu, Bin Zhao, Jiaxin Mei, Haixuan Yuan, Jingwei Xue, Feng Feng, Fulei Liu · 2026 · Cellular Immunology
  60. Thr3/Ser90 phosphorylation-stabilized S100A8 regulates cholesterol metabolism in glioblastoma stem cells
    Wanzhi Cai, Jingming Hu, Chengzhi Chen, Hao Shi, Xu L, Shenghao Zhu, Ning Liu, Xiuxing Wang, Jeremy N. Rich, Yiming Tu et al. · 2026 · Oncogene
  61. Engineered biomimetic exosomes for small activating RNA delivery: Low-density lipoprotein receptor–related protein-1 targeted blood-brain barrier penetration and dual therapy in intracerebral Hemorrhage
    Lixing Xu, Yan Song, Huimin Tao, Luyun Ni, Haiqin Huang, Jianfei Shen · 2026 · Journal of Controlled Release
  62. Modulation of Cancer Progression by Tumor Microenvironmental Leukocyte-Expressed microRNAs
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  63. Endogenous Ligand-Induced Activation of TLR4 in Pre-metastatic Phase Is Both Downstream and Upstream of TNF Signaling
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  64. Role of Innate Immunity in Cancers and Antitumor Response
    Masahisa Jinushi, Muhammad Baghdadi · 2014 · Springer eBooks
  65. Regulation of Tumor Progression and Metastasis by Bone Marrow-Derived Microenvironments
    Tina El Rayes, Dingcheng Gao, Nasser Khaled Altorki, Thomas R. Cox, Janine Terra Erler, Vivek Mittal · 2017 · Springer eBooks
  66. Myeloid-derived Suppressor Cells in Cancer: A Review on the Pathogenesis and Therapeutic Potentials
    Seidu A. Richard · 2018 · The Open Cancer Immunology Journal
  67. Metastasis: A Major Driver of Cancer Pathogenesis
    Pradeep Singh Cheema, Gaurav Kumar, Sonam Mittal, Deepak Parashar, Anjali Geethadevi, Kapilesh Jadhav, Hardeep Singh Tuli · 2020 · Springer eBooks
  68. Explanation of Metastasis by Homeostatic Inflammation
    Yoshiro Maru · 2021 · Springer eBooks
  69. Therapeutic Potential
    Yoshiro Maru · 2021 · Springer eBooks
  70. Evidence for Existence of Endogenous TLR4 Ligands
    Yoshiro Maru · 2021 · Springer eBooks
  71. Premetastatic Microenvironment
    Yoshiro Maru · 2016 · Springer eBooks
  72. The Role of Tumour-Associated Macrophages in Malignant Invasion
    Claudia Rebecca Binder · 2011 · Springer eBooks
  73. S100A9 (S100 calcium binding protein A9)
    Claus Kerkhoff, Saeid Ghavami · 2012 · Atlas of Genetics and Cytogenetics in Oncology and Haematology
  74. The level of some blood serum inflammatory factors in depending on the morphological features of the primary tumor of of cervical cancer
    E. V. Kayukova, Tatiana E. Belokrinitskaya, Leonid F. Sholokhov, Павел Петрович Терешков · 2019 · Advances in molecular oncology
  75. Cancer Biology and Implications for the Perioperative Period
    Nicholas J. S. Perry, Shaman Jhanji, George Poulogiannis · 2022 · Elsevier eBooks
  76. Role of Cancer Stem Cells in Metastasis
    Giovanna Merchand‐Reyes, Rosana Pelayo, Lenin Pavón, Richard G. Pestell, Marco Antonio Velasco-Velázquez · 2014
  77. Molecular Genetics of Metastasis
    Georg F. Weber · 2017 · Encyclopedia of Life Sciences
  78. Premetastatic Niches
    Kevin L. Bennewith, Janine Terra Erler, Amato J. Giaccia · 2010 · Wiley eBooks
  79. Cancer Immunology
    Mahsa Keshavarz‐Fathi, Mahdis Keshavarz-Fathi, Nima Rezaei · 2021 · Elsevier eBooks
  80. Therapeutic Potential
    Yoshiro Maru · 2016 · Springer eBooks
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  82. Myeloid-Derived Suppressor Cells in Cancer
    Fatin Nurizzati Mohd Jaya, Dmitry I. Gabrilovich · 2024 · Elsevier eBooks
  83. Combined inhibition of S100A4 and TIGIT suppresses late-stage breast cancer metastasis to the lung by activating T and NK cells
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    S. Tanner Roach, Qianxun Wang, Rishi Patel, Serena Thomas, Braulio Aguilar, Chinwe Obianuju Ewenighi, Lauren Raasch, William A. Müller, L.A. Naiche, Jan Kitajewski · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  85. Inflammation and Lung Cancer: The Link to Angiogenesis
    Tina El Rayes, Raúl Catena, Shahin Rafii, Nasser Khaled Altorki, Vivek Mittal · 2015 · Springer eBooks
  86. VIRAL-ALLERGEN INTERACTIONS: INSIGHTS INTO THE ORIGINS OF ALLERGIC ASTHMA.
    Amal A Al-Garawi · 2012 · MacSphere (McMaster University)
  87. Cancer Stem Cells and Their Niche
    Guadalupe Aparicio, Vanessa Médina, Silvia D�az, Luis M. Antón Aparicio · 2011 · InTech eBooks
  88. Der metastatische Zyklus: metastatische Nischen und Tumorzell‐Dissemination
    Cyrill Géraud, Philipp-Sebastian Reiners-Koch, Friederike Damm, Kai Schledzewski, Sergij Goerdt · 2014 · JDDG Journal der Deutschen Dermatologischen Gesellschaft
  89. Complement Inhibition in the Immunotherapy of Breast Cancer
    Maciej M. Markiewski · 2013
  90. Exploring the Earliest Steps in Metastasis: The Pre-metastatic Niche
    Marianna Papaspyridonos, David C. Lyden, Rosandra Natasha Kaplan · 2011 · Cambridge University Press eBooks
  91. Toll-Like Receptors and Neuroinflammation
    Sung Joong Lee · 2013 · Advances in neurobiology
  92. Evaluation der Einflüsse der potenziellen Störfaktoren Hämaturie und Harnwegsinfekt sowie der Art der Uringewinnung auf die Wertigkeit der Urinmarker Zytologie, UroVysion, NMP22 ELISA und uCyt+ für die Diagnostik des Urothelkarzinoms der Harnblase
    Ärztlicher Direktor, Arnulf Stenzl · 2011
  93. Dissemination Tumor Cell Interactions during Hematogenous - HostInitial Hours of Metastasis: The Importance of Cooperative
    Myriam Labelle, Richard O. Hynes · 2012
  94. Evidence for Existence of Endogenous TLR4 Ligands
    Yoshiro Maru · 2016 · Springer eBooks
  95. Differential Activation of Macrophages in Tumors
    Shalini Persaud Outram, S. Joseph Leibovich · 2013 · CRC Press eBooks
  96. Explanation of Metastasis by Homeostatic Inflammation
    Yoshiro Maru · 2016 · Springer eBooks
  97. Innate Immune Responses and Cancer Metastasis
    Yoshiro Maru · 2016 · Elsevier eBooks
  98. Establishment of Diagnosis for Early Metastasis
    Sachie Hiratsuka · 2016 · Springer eBooks
  99. Pancreatic Cancer Fostered Immunosuppression Privileges Tumor Growth and
    Elisa Gnatta, Mario Plebani, Daniela Basso · 2014
  100. Contributions of the Bone Marrow Microenvironment to Bone and Skeletal Metastasis.
    Fabiana Naomi Soki · 2014 · Deep Blue (University of Michigan)