The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase
Abstract
A large number of macrophages and haematopoietic progenitor cells accumulate in pre-metastatic lungs in which chemoattractants, such as S100A8 and S100A9, are produced by distant primary tumours serving as metastatic soil. The exact mechanism by which these chemoattractants elicit cell accumulation is not known. Here, we show that serum amyloid A (SAA) 3, which is induced in pre-metastatic lungs by S100A8 and S100A9, has a role in the accumulation of myeloid cells and acts as a positive-feedback regulator for chemoattractant secretion. We also show that in lung endothelial cells and macrophages, Toll-like receptor (TLR) 4 acts as a functional receptor for SAA3 in the pre-metastatic phase. In our study, SAA3 stimulated NF-kappaB signalling in a TLR4-dependent manner and facilitated metastasis. This inflammation-like state accelerated the migration of primary tumour cells to lung tissues, but this was suppressed by the inhibition of either TLR4 or SAA3. Thus, blocking SAA3-TLR4 function in the pre-metastatic phase could prove to be an effective strategy for the prevention of pulmonary metastasis.
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Higher apoptotic rates in the S100A9-/- group are not due to defective accumulation of myeloid cells.
“This result ruled out the possibility that higher apoptotic rates in the S100A9−/− group were due to a defective accumulation of myeloid cells (Hiratsuka et al., 2008).”
From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Hiratsuka et al., 2008
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- Authors
- Hiratsuka, S., Watanabe, A., Sakurai, Y., Akashi-Takamura, S., Ishibashi, S., Miyake, K., Shibuya, M., Akira, S., Aburatani, H., & Maru, Y.
- Affiliations
- Tokyo Women's Medical University (JP)
- Research Center for Advanced Science and Technology, The University of Tokyo (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Research Institute for Microbial Diseases, The University of Osaka (JP)
- Corresponding author
- Maru, Yoshiro
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2008-09-28
- Volume
- 10
- Issue
- 11
- Pages
- 1349-1355
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W1970784817
- Cited by
- 642
- References
- 30
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 19 · 2023: 37 · 2022: 36 · 2021: 49 · 2020: 39 · 2019: 50 · 2018: 39 · 2017: 28 · 2016: 40 · 2015: 46 · 2014: 35 · 2013: 48 · 2012: 40
- FWCI
- 14.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (20221009)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- S100A8, S100A9, serum amyloid A3, TLR4, lung metastasis, chemoattractants, macrophages, hematopoietic progenitor cells, NF-κB signaling, positive feedback loop, pulmonary endothelial cells, tumor cell migration, metastasis prevention
- MeSH terms
- Serum Amyloid A Protein, Animals, Cell Movement, Escherichia coli, Glutathione Transferase, Luciferases, Lung, Macrophages, Mice, Inbred C3H, Mice, Inbred C57BL, Neoplastic Cells, Circulating, Neoplasm Metastasis, S100 Proteins, Promoter Regions, Genetic, Recombinant Fusion Proteins, NF-kappa B, Genes, Reporter, Mice, Knockout, Paracrine Communication, Myeloid Cells, Calgranulin A, Calgranulin B, Endothelial Cells, Toll-Like Receptor 4, Mice
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