Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells

Wagner, Thomas F.J., Loch, Sabine, Lambert, Sachar, Straub, Isabelle, Mannebach, Stefanie, Mathar, Ilka, Düfer, Martina, Lis, Annette, Flockerzi, Veit, Philipp, Stephan E., Oberwinkler, Johannes·2008·Nature Cell Biology
DOI 10.1038/ncb1801

Cited by (386)

Items 301–386 of 386

  1. Muscarinic Receptor Antagonism and TRPM3 Activation as Stimulators of Mitochondrial Function and Axonal Repair in Diabetic Sensorimotor Polyneuropathy
    S. P. S. Chauhan, Nigel A. Calcutt, Paul Fernyhough · 2025 · International Journal of Molecular Sciences
  2. Physiological functions and pharmacological targeting of transient receptor potential channels
    Vladimir Chubanov, Christian M. Grimm, Kerstin Hill, Michael Schaefer, Michael Köttgen, Ursula Storch, Michael Mederos y Schnitzler, Veronika Kudrina, Anna Erbacher, Thomas W. Gudermann · 2025 · Pharmacological Reviews
  3. Direct crosstalk between GPCRs and ion channels via G proteins
    Sun-Hong Kim, Jinhyeong Kim, Insuk So, Hyung Ho Lee · 2025 · Experimental & Molecular Medicine
  4. Thermo‐ TRP regulation by endogenous factors and its physiological function at core body temperature
    Makiko Kashio · 2025 · Physiological Reports
  5. Importance of TRP channels in pain implications for stress
    Ashutosh Kumar · 2012 · Frontiers in Bioscience-Scholar
  6. Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model
    Ádám István Horváth, Anita Steib, Andrea Kinga Nehr-Majoros, Boglárka Kántás, Ágnes Király, Márk Racskó, Balázs István Tóth, Eszter Szánti‐Pintér, Eva Kudová, Rita Skoda‐Földes et al. · 2024 · International Journal of Molecular Sciences
  7. Expression of the C-Terminal Domain of Phospholipase Cβ3 Inhibits Signaling via Gαq-Coupled Receptors and Transient Receptor Potential Channels
    Gerald Thiel, Oliver G. Rößler · 2022 · International Journal of Molecular Sciences
  8. Transient Receptor Potential (TRP) Cation Channels in Diabetes
    Koenraad Philippaert, Rudi Vennekens · 2015 · Elsevier eBooks
  9. TRP channels as molecular targets to relieve endocrine-related diseases
    Yusheng Liu, Yihan Lyu, Hongmei Wang · 2024 · Elsevier eBooks
  10. A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens
    Yuefang Zhou, Thomas M. Bennett, Philip A. Ruzycki, Zhaohua Guo, Yuqing Cao, Mohammad Shahidullah, Nicholas A. Delamere, Alan Shiels · 2024 · Cells
  11. The sperm-specific K+ channel Slo3 is inhibited by albumin and steroids contained in reproductive fluids
    Johannes Lorenz, Clara Eisenhardt, Teresa Mittermair, A. Kulle, P. Holterhus, Manfred Fobker, W. Boenigk, V. Nordhoff, H. M. Behre, T. Strünker et al. · 2024 · Frontiers in Cell and Developmental Biology
  12. Activation of TRPA1 and TRPM3 triggers Ca 2+ waves in central terminals of sensory neurons and facilitates synaptic activity in the spinal dorsal horn
    Yaroslav Andrianov, Alex L. Keyes, Charles A. Warwick, Miriam C. McDonough, Leonid P. Shutov, Kavita Singh Solanki, Jon M. Resch, Alexander G. Bassuk, Nana V. Voitenko, Pavel V. Belan et al. · 2025 · The Journal of Physiology
  13. TRPM3-Induced Gene Transcription Is under Epigenetic Control
    Gerald Thiel, Oliver G. Rößler · 2022 · Pharmaceuticals
  14. Pain enters through the side door
    Emily R. Liman · 2014 · Nature Chemical Biology
  15. The Underlying Mechanism of Modulation of Transient Receptor Potential Melastatin 3 by protons
    Md Zubayer Hossain Saad, Liuruimin Xiang, Yan-Shin J. Liao, Leah R. Reznikov, Jianyang Du · 2021 · Frontiers in Pharmacology
  16. The Role of Thermosensitive Ion Channels in Mammalian Thermoregulation
    Yawen Chen, Kun Song · 2021 · Advances in experimental medicine and biology
  17. 6.4 Biophysics of TRP Channels
    Moshe Parnas, Maximilian Peters, Baruch Minke · 2012 · Elsevier eBooks
  18. Transient Receptor Potential Ion Channels in the Etiology and Pathomechanism of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
    D. Staines, Stanley Du Preez, Hélène Cabanas, Cassandra Balinas, Natalie Eaton-Fitch, Rachael Passmore, Rebekah Maksoud, J. Redmayne, Sonya Marshall‐Gradisnik · 2018 · International Journal of Clinical Medicine
  19. Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
    Etianne Martini Sasso, Teagan Er, Natalie Eaton-Fitch, Livia C. Hool, Katsuhiko Muraki, Sonya Marshall‐Gradisnik · 2026 · Frontiers in Medicine
  20. Melastatin family Transient Receptor Potential channels support spermatogenesis in planarian flatworms
    Haley Nicole Curry, Roger Huynh, Labib Rouhana · 2025 · The International Journal of Developmental Biology
  21. Sphingosylphosphorylcholine induces itch via activation of TRPM3 and TRPA1 in mice
    Da Eun Song, Diwas Rawal, Wook‐Joo Lee, Won‐Sik Shim · 2025 · Biochemical Pharmacology
  22. A duo of redox-sensitive pore-loop cysteines controls the activity of the neural ion channel TRPM3
    Katharina Held, Evelien Van Hoeymissen, Ilhem Dallali, Eleonora Persoons, Bahar Bazeli, Robbe Roelens, Stijn Robben, Caroline Wuyts, Marie Mulier, Sílvia Pinto et al. · 2026 · Communications Chemistry
  23. Multidisciplinary Advances Address the Challenges in Developing Drugs against Transient Receptor Potential Channels to Treat Metabolic Disorders
    Yibing Wang · 2022 · ChemMedChem
  24. Determination of Beta-Cell Function: Ion Channel Function in Beta Cells
    Martina Düfer · 2012 · Humana Press eBooks
  25. TRP Channels in Reproductive (Neuro)Endocrinology
    Trese Leinders‐Zufall, Ulrich Boehm · 2014 · Handbook of experimental pharmacology
  26. Stimulation of TRPM3 channels increases the transcriptional activation potential of Elk-1 involving cytosolic Ca2+, extracellular signal-regulated protein kinase, and calcineurin
    Sandra Rubil, Gerald Thiel · 2018 · European Journal of Pharmacology
  27. TRPM3 gating in planar lipid bilayers defines peculiar agonist specificity
    Lusine H. Demirkhanyan, Kunitoshi Uchida, Makoto Tominaga, Eleonora Zakharian · 2016 · Channels
  28. Crosstalk between noncoding RNAs and autophagy in renal cell carcinoma: Deciphering molecular pathways and therapeutic prospects
    Mina Alimohammadi, Mojgan Noroozi, Alireza Mafi, Fateme Zare Khormizi, Amirhosein Abbasi, Najma Farahani, Seyedeh Mahdieh Khoshnazar, Mehrdad Hashemi, Afshin Taheriazam, Kiavash Hushmandi · 2025 · Cancer Cell International
  29. TRPM3 mediates spontaneous pain and mechanical allodynia in a mouse model of chronic orofacial neuropathy
    Kristof R. Deseure, Ilhem Dallali, Sílvia Pinto, Katrien Luyten, Andrei Segal, Nele Van Ranst, Robbe Roelens, Sean Corbett, Stuart Murray, Eleonora Persoons et al. · 2026 · Cell Reports Medicine
  30. Monoacylglycerol as a Metabolic Coupling Factor in Glucose-Stimulated Insulin Secretion
    Shangang Zhao, Jose Iglesias, Yves Mugabo, Marie‐Line Peyot, Erik C. Joly, S.R. Murthy Madiraju, Marc Prentki · 2013 · Canadian Journal of Diabetes
  31. Association of protein function-altering variants with cardiometabolic traits: the strong heart study
    Yue Shan, Shelley A. Cole, Karin Haack, Phillip E. Melton, Lyle G. Best, Chris Bizon, Sayuko Kobes, Çiğdem Köroğlu, Leslie J. Baier, Robert L. Hanson et al. · 2022 · Scientific Reports
  32. Slick potassium channels limit TRPM3-mediated activation of sensory neurons
    Patrick Engel, Fangyuan Zhou, Bang Tam Thi Tran, Achim Schmidtko, Ruirui Lu · 2024 · Frontiers in Pharmacology
  33. TRP Channel Reconstitution in Lipid Bilayers
    Eleonora Zakharian · 2019 · Methods in molecular biology
  34. In vitro and in vivo impacts of nifedipine and diltiazem on praziquantel chemotherapy in murine Schistosoma mansoni
    Neveen Adel Madbouly, Mohammed Emam, Malak Ayman, Mohammed Ayman, Ibraheem Rabia, Azza El Amir · 2022 · Experimental Parasitology
  35. Role of novel de novo gain-of-function TRPM3 mutations in a spectrum of neurodevelopmental disorders
    Makiko Kashio, Makoto Tominaga · 2023 · Cell Calcium
  36. Novel characterization of endogenous transient receptor potential melastatin 3 ion channels from Gulf War Illness participants
    Sonya Marshall‐Gradisnik, Etianne Martini Sasso, Natalie Eaton-Fitch, Peter Kenneth Smith, James Nicholas Baraniuk, Katsuhiko Muraki · 2024 · PLoS ONE
  37. Stimulus–Transcription Coupling of TRPM3 Channels: A Signaling Pathway from the Plasma Membrane to the Nucleus
    Gerald Thiel, Oliver G. Rößler · 2025 · Biomolecules
  38. Nociceptive TRP Channels and Sex Steroids
    Óscar Enciso-Pablo, Karina Angélica Méndez-Reséndiz, Tamara Rosenbaum, Sara L. Morales‐Lázaro · 2021 · IntechOpen eBooks
  39. TRP channel antagonists
    Ari Koivisto, Lauri M. Louhivuori, Serhii Vakal, R. Lund, William Hennah · 2024 · Elsevier eBooks
  40. A high-throughput assay for the measurement of Ca2+ oscillations and insulin release from uniformly sized mouse β-cell (MIN6) spheroids
    Stijn Robben, Patricia Davidson, Rita S. Rodrigues Ribeiro, Thomas Voets · 2026 · eLife
  41. Renal TRPM3 Channels Regulate Blood Pressure via Tubuloglomerular Feedback and Plasma Volume Control
    Jorge Rojo-Mencía, Lucía Alonso-Carbajo, Marycarmen Arévalo‐Martínez, Lucía Benito-Salamanca, Karel Talavera, María Teresa Pérez-García, José R. López‐López, Pilar Cidad · 2025 · Hypertension
  42. TRP channels as drug targets: Structural insights and therapeutic relevance
    Vijay K. Boda, Wei Li · 2026 · Elsevier eBooks
  43. The TRPM family: key players and mechanisms in energy metabolism
    Mengxue Han, Geyang Xu · 2026 · Cell Calcium
  44. Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3
    Bahar Bazeli, Alexander V. Shkumatov, Stephan Schenck, Jean-Christophe Vanherck, Annelies Janssens, Stéphane A. H. Spieser, Damien Marchand, Robbe Roelens, Patrick Chaltin, Arnaud Marchand et al. · 2026 · Nature Communications
  45. TRPV1 Antagonism: From Research to Clinic
    Mark S. Nash, Jan Martin Verkuyl, Gurdip Bhalay · 2014 · Royal Society of Chemistry eBooks
  46. Transient Receptor Potential Melastatin 3 and Intracellular Calcium in Natural Killer Cells in Multiple Sclerosis
    Laura Clarke, Broadley Simon, Thao U. Nguyen, Samantha Johnston, Natalie Eaton-Fitch, Donald Staines, Sonya Marshall‐Gradisnik · 2018 · International Journal of Clinical Medicine
  47. Hormones of the Testes
    Eleonora Zakharian · 2019 · Elsevier eBooks
  48. Calcium Signaling in the Islets
    Md. Shahidul Islam · 2014 · Springer eBooks
  49. TRP channel expression in the tumor microenvironment: Implications for tumor progression and metastasis
    Nuray Erin · 2024 · Elsevier eBooks
  50. Biology of TRP channels
    Gisela E. Rangel‐Yescas, León D Islas · 2024 · Elsevier eBooks
  51. TRPM1 and Congenital Stationary Night Blindness
    Shoichi Irie, Takahisa Furukawa · 2013 · Springer eBooks
  52. TRP Channels in the Sensation of Heat
    Chun‐Hsiang Tan, Peter Anthony McNaughton · 2015 · Springer eBooks
  53. OVERCOMING TREATMENT RESISTANCE OF DEPRESSION IN AN ADVANCED AGE FEMALE PATIENT WITH ADDISON DISEASE: A LITERATURE REVIEW WITH CLINICAL CASE PRESENTATION
    Anastasia Yu. Bykova, Yuriy Vitalevich Bykov, Roman Aleksandrovich Bekker · 2021 · Siberian Journal of Life Sciences and Agriculture
  54. Electrophysiology of Islet Cells
    Gisela Drews, Peter Krippeit‐Drews, Martina Düfer · 2014 · Springer eBooks
  55. The Concise Guide to PHARMACOLOGY 2013/14: Ion Channels
    S P H Alexander, Helen E. Benson, Elena Faccenda, Adam J Pawson, Joanna L Sharman, William A. Catterall, Michael Spedding, John A. Peters, Anthony J. Harmar, CGTP Collaborators · 2013 · British Journal of Pharmacology
  56. Neurosteriod enhancement of glutamatergic transmission via transient receptor potential melastatin 3 chanels in the developing cerebellum
    Paula A. Zamudio · 2011 · UNM’s Digital Repository (University of New Mexico)
  57. TRP Channels and Human Diseases
    Bernd Nilius, Rudi Vennekens · 2010 · Wiley eBooks
  58. Compairing quantitative trait analysis to qualitative trait analysis for complex traits disease: A genome wide association study for hyperlipidemia
    Iksoo Huh, Sohee Oh, Eunjin Lee, Taesung Park · 2010 · IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)
  59. D-erythro-Sphingosine and Pregnenolonesulphate activate TRPM3 channels synergistically in INS- 1E cells
    Md Abdul Halim · 2017 · Bangladesh Journal of Medical Science
  60. Characterisation of substance P and transient receptor potential melastatin channel messenger RNA and protein expression in acute and chronic neurological disorders.
    Naomi L. Cook · 2010 · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
  61. L-type blocker STIMulate Ca2+ entry in synthetic VSMCs
    Marc Freichel, Roger Ottenheijm · 2020 · Cell Calcium
  62. Therapeutic Potential of TRP Channels in the Targeting of Rheumatoid Arthritis Synovial Fibroblasts
    Brittany Schwam · 2021
  63. Small Self‐Cleaving Ribozymes in the Genomes of Vertebrates
    Marcos de la Peña · 2021 · Wiley eBooks
  64. Dysfunctional Circadian Rhythm Is Associated with Food Consumption, Obesity and Related Metabolic Diseases: Role of Ion Channels
    Abdülhadi Cihangir Uğuz, Lourdes Franco Hernández, Jaipaul Singh, Ana Beatriz Rodriguez Moratinos, José Antonio Pariente · 2021 · Advances in biochemistry in health and disease
  65. Calcium Signaling in the Islets
    Md. Shahidul Islam · 2014 · Springer eBooks
  66. Electrophysiology of Islet Cells
    Gisela Drews, Peter Krippeit‐Drews, Martina Düfer · 2013 · Springer eBooks
  67. TRPM3
    Johannes Oberwinkler · 2017 · Springer eBooks
  68. TRPM3
    Johannes Oberwinkler · 2017 · Springer eBooks
  69. Transient Receptor Potential (TRP) Channels non Genomic Regulation by Sex Steroids: The Less Traveled Pathway
    Monika Haoui, Dimitra Gkika · 2022 · Elsevier eBooks
  70. Decision letter: Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders
    2022 · eLife
  71. TRP channels in respiratory disorders
    Sara Jane Bonvini, Michael A. Wortley, Maria Gabriela Belvisi · 2024 · Elsevier eBooks
  72. Thermo-TRPs: Temperature-sensitive TRP channels
    Kirill D. Nadezhdin, Alexander I. Sobolevsky · 2024 · Elsevier eBooks
  73. TRPM3: An emerging pain target (and more)
    Marc Behrendt · 2024 · Elsevier eBooks
  74. The ExPAND Study: A Prospective Association Study into Endometriosis-Associated Pain, Neurosteroid Synthesis, and TRPM3
    Eleonora Persoons, Céline Bafort, Pilar Van Mechelen, Martina Ciprietti, Katrien Luyten, Melissa Benoit, Arne Vanhie, Thomas Voets, Carla Tomassetti, Joris Vriens · 2025 · Biomolecules
  75. Additional file 1 of The effect of IL-2 stimulation and treatment of TRPM3 on channel co-localisation with PIP2 and NK cell function in myalgic encephalomyelitis/chronic fatigue syndrome patients
    Natalie Eaton-Fitch, Hélène Cabanas, Stanley Du Preez, Donald Staines, Marshall-Gradisnik, Sonya · 2021 · Figshare
  76. Additional file 1 of Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients
    Natalie Eaton-Fitch, Stanley Du Preez, Hélène Cabanas, Katsuhiko Muraki, Donald Staines, Marshall-Gradisnik, Sonya · 2022 · Figshare
  77. A high-throughput assay for the measurement of Ca2+ oscillations and insulin release from uniformly sized mouse β-cell (MIN6) spheroids
    Stijn Robben, Patricia M. Davidson, Rita S. Rodrigues Ribeiro, Thomas Voets · 2026 · eLife
  78. A high-throughput assay for the measurement of Ca2+-oscillations and insulin release from uniformly sized β-cell spheroids
    Stijn Robben, Patricia M. Davidson, Rita S. Rodrigues Ribeiro, Thomas Voets · 2026 · eLife
  79. Sensibilité des cellules de Merkel humaines au froid : vers un rôle des complexes de Merkel dans la sensibilité thermique cutanée ?
    Yann Roudaut · 2014 · theses.fr (ABES)
  80. Contribution des propriétés bistables du réseau moteur lombaire au tonus postural et au rythme locomoteur : caractérisation des canaux ioniques sous-jacents
    Benoît Drouillas · 2022 · theses.fr (ABES)
  81. Transient receptor potential melastatin 3 ion channel expressed in sensory neurons mediates osteoarthritis pain in mice
    Robson da Costa, Suelen Pereira, Clive Gentry, Fabiana C. Dias, Bianca de Lima Almeida, Margot Maurer, Laura I. Primicheru, Lio Moreira, Stefanie Mannebach, Petra Weißgerber et al. · 2026 · Osteoarthritis and Cartilage
  82. Transient Receptor Potential (TRP) channels: Quantitative biophysical correlates of cognitive function across brain regions.
    Geoffrey E. Woodard, Catherine Julien · 2026 · Behavioural Brain Research
  83. Médecine de la douleur
    Manon Defaye, Christophe Altier · 2025 · Dunod eBooks
  84. Altered TRPM3‐Dependent Cytosolic and Mitochondrial Calcium Influx in Natural Killer Cells of Post‐COVID‐19 Condition Patients
    Chandi Tabeth Magawa, Natalie Eaton-Fitch, Katsuhiko Muraki, Sonya Marshall‐Gradisnik · 2026 · European Journal of Immunology
  85. Integrated network pharmacology and molecular docking based insights into transient receptor potential melastatin3 regulatory mechanism in COPD
    Shalini Sharma, Subhashini · 2026 · In Silico Pharmacology
  86. TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala
    Attila Gyéresi, Laura Mundrucz, Máté Deák, Angéla Kecskés, Éva Borbély, Viktória Kormos, Balázs Gaszner, Orsolya Salamonné Mihály, Balázs István Tóth, Joris Vriens et al. · 2026 · British Journal of Pharmacology