Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436 · see citing works

Image processing with ImageJ

Abràmoff, M. D., Magalhães, P. J., & Ram, S. J. (2004) · Utrecht University Repository (Utrecht University) · Cited by 11,816 · see citing works

TGF-β SIGNAL TRANSDUCTION

Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571 · see citing works

Triggering and amplifying pathways of regulation of insulin secretion by glucose.

Henquin, J. C. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1751 · Cited by 1,201 · see citing works

Establishment of 2-mercaptoethanol-dependent differentiated insulin- secreting cell lines

Asfari, M., Janjic, D., Meda, P., Li, G., Halban, P. A., & Wollheim, C. B. (1992) · Endocrinology · doi:10.1210/endo.130.1.1370150 · Cited by 1,165 · see citing works

Neurosteroids: endogenous regulators of the GABAA receptor

Belelli, D., & Lambert, J. J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1703 · Cited by 1,159 · see citing works

Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances

Hwang, S. W., Cho, H., Kwak, J., Lee, S.-Y., Kang, C.-J., Jung, J., Cho, S., Min, K. H., Suh, Y., Kim, D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.6155 · Cited by 1,047 · see citing works

Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels

Watanabe, H., Vriens, J., Prenen, J., Droogmans, G., Voets, T., & Nilius, B. (2003) · Nature · doi:10.1038/nature01807 · Cited by 1,030 · see citing works

The TRP Superfamily of Cation Channels

Montell, C. (2005) · Science s STKE · doi:10.1126/stke.2722005re3 · Cited by 993 · see citing works

Nongenomic actions of steroid hormones

Lösel, R., & Wehling, M. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1009 · Cited by 980 · see citing works

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

Trevisani, M., Siemens, J., Materazzi, S., Bautista, D. M., Nassini, R., Campi, B., Imamachi, N., Andrè, E., Patacchini, R., Cottrell, G. S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705923104 · Cited by 775 · see citing works

NEUROSTEROIDS: A NOVEL FUNCTION OF THE BRAIN

Baulieu, E. E. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00071-7 · Cited by 624 · see citing works

PERMEATION AND SELECTIVITY OF TRP CHANNELS

Owsianik, G., Talavera, K., Voets, T., & Nilius, B. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040204.101406 · Cited by 548 · see citing works

Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.

Wu, F., Gibbs, T. T., & Farb, D. H. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)12923-4 · Cited by 534 · see citing works

Interaction of Steroid Hormone Receptors with the Transcription Initiation Complex

Beato, M., & Sánchez‐Pacheco, A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-6-587 · Cited by 402 · see citing works

Tissue Distribution Profiles of the Human TRPM Cation Channel Family

Fonfría, E., Murdock, P. R., Cusdin, F. S., Benham, C. D., Kelsell, R. E., & McNulty, S. (2006) · Journal of Receptors and Signal Transduction · doi:10.1080/10799890600637506 · Cited by 367 · see citing works

Molecular and Functional Characterization of the Melastatin-related Cation Channel TRPM3

Grimm, C. M., Kraft, R., Sauerbruch, S., Schultz, G., & Harteneck, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300945200 · Cited by 362 · see citing works

Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains

Kunert‐Keil, C., Bisping, F., Krüger, J., & Brinkmeier, H. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-159 · Cited by 329 · see citing works

Expression and Characterization of Human Transient Receptor Potential Melastatin 3 (hTRPM3)

Lee, N., Chen, J., Sun, L. R., Wu, S., Gray, K. R., Rich, A. J., Huang, M., Lin, J.-H., Feder, J. N., Janovitz, E. B., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211232200 · Cited by 229 · see citing works

Alternative Splicing Switches the Divalent Cation Selectivity of TRPM3 Channels

Oberwinkler, J., Lis, A., Giehl, K. M., Flockerzi, V., & Philipp, S. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503092200 · Cited by 224 · see citing works

Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat

Mayo, W., Dellu, F., Robel, P., Cherkaoui, J., Le Moal, M., Baulieu, E.-E., & Simon, H. (1993) · Brain Research · doi:10.1016/0006-8993(93)91524-v · Cited by 212 · see citing works

Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging

Vallée, M., Mayo, W., & Moal, M. L. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00135-7 · Cited by 198 · see citing works

Herbal Compounds and Toxins Modulating TRP Channels

Vennekens, R., Vriens, J., & Nilius, B. (2008) · Current Neuropharmacology · doi:10.2174/157015908783769644 · Cited by 185 · see citing works

Intrinsic Regulators of Pancreatic β-Cell Proliferation

Heit, J. J., Karnik, S. K., & Kim, S. K. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104425 · Cited by 165 · see citing works

Children with classic congenital adrenal hyperplasia have elevated serum leptin concentrations and insulin resistance: potential clinical implications.

Charmandari, E., Weise, M., Bornstein, S. R., Eisenhofer, G., Keil, M. F., Chrousos, G. P., & Merke, D. P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8456 · Cited by 164 · see citing works

Activation of the Melastatin-Related Cation Channel TRPM3 by d-erythro-Sphingosine

Grimm, C. M., Kraft, R., Schultz, G., & Harteneck, C. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.006734 · Cited by 158 · see citing works

Regulation of Insulin Secretion in Islets of Langerhans by Ca2+Channels

Mears, D. (2004) · Journal of Membrane Biology · doi:10.1007/s00232-004-0692-9 · Cited by 148 · see citing works

Insulin insensitivity in adrenal hyperplasia due to nonclassical steroid 21-hydroxylase deficiency.

Speiser, P. W., Serrat, J., New, M. I., & Gertner, J. M. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.6.1464643 · Cited by 143 · see citing works

Neurosteroid-Induced Plasticity of Immature Synapses via Retrograde Modulation of Presynaptic NMDA Receptors

Mameli, M., Carta, M., Partridge, L. D., & Valenzuela, C. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3877-04.2005 · Cited by 124 · see citing works

Sulfated steroids as endogenous neuromodulators

Gibbs, T. T., Russek, S. J., & Farb, D. H. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.07.031 · Cited by 114 · see citing works

A steroid modulatory domain on NR2B controls N -methyl- d -aspartate receptor proton sensitivity

Jang, M., Mierke, D. F., Russek, S. J., & Farb, D. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401838101 · Cited by 93 · see citing works

Oscillations, Intercellular Coupling, and Insulin Secretion in Pancreatic β Cells

MacDonald, P. E., & Rorsman, P. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040049 · Cited by 88 · see citing works

Serum Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate, and Pregnenolone Sulfate Concentrations in Patients with Hyperthyroidism and Hypothyroidism

Tagawa, N., Tamanaka, J., Fujinami, A., Kobayashi, Y., Takano, T., Fukata, S., Kuma, K., Tada, H., & Amino, N. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.4.523 · Cited by 70 · see citing works

Serum Concentrations of Some Neuroactive Steroids in Women Suffering from Mixed Anxiety-Depressive Disorder

Bičı́ková, M., Tallová, J., Hill, M., Krausová, Z., & Hampl, R. (2000) · Neurochemical Research · doi:10.1023/a:1026622704704 · Cited by 68 · see citing works

Pattern of Plasma Pregnenolone Sulfate Levels in Humans from Birth to Adulthood

PERETTI, E. D., & Mappus, E. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-3-550 · Cited by 67 · see citing works

Single cell assay of exocytosis from pancreatic islet B cells

Gillis, K. D., & Misler, S. (1992) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00378654 · Cited by 60 · see citing works

Plasma Steroid Concentrations in Maternal and Umbilical Circulation after Spontaneous Onset of Labor*

Mathur, R. S., Landgrebe, S. C., Moody, L. O., POWELL, S., & Williamson, H. O. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-6-1235 · Cited by 55 · see citing works

TRP Channels of the Pancreatic Beta Cell

Jacobson, D. A., & Philipson, L. H. (2007) · Springer eBooks · doi:10.1007/978-3-540-34891-7_24 · Cited by 49 · see citing works

Sex- and age-related changes in epitestosterone in relation to pregnenolone sulfate and testosterone in normal subjects

Havlíková, H., Hill, M., Hampl, R., & Stárka, L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8499 · Cited by 45 · see citing works

TRPM3

Oberwinkler, J., & Philipp, S. E. (2007) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-34891-7_15 · Cited by 45 · see citing works

Two neuroactive steroids in midpregnancy as measured in maternal and fetal sera and in amniotic fluid

Bičı́ková, M., Klak, J., Hill, M., Žižka, Z., Hampl, R., & Calda, P. (2002) · Steroids · doi:10.1016/s0039-128x(01)00196-9 · Cited by 41 · see citing works

Mechanism underlying inhibition of the capsaicin receptor-mediated current by pregnenolone sulfate in rat dorsal root ganglion neurons

Chen, S.-C., & Wu, F. (2004) · Brain Research · doi:10.1016/j.brainres.2004.08.053 · Cited by 35 · see citing works

Neurosteroid pregnenolone sulfate enhances glutamatergic synaptic transmission by facilitating presynaptic calcium currents at the calyx of Held of immature rats

Hige, T., Fujiyoshi, Y., & Takahashi, T. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05080.x · Cited by 25 · see citing works

Effects on Membrane Capacitance of Steroids with Antagonist Properties at GABAA Receptors

Mennerick, S. J., Lamberta, M., Shu, H., Hogins, J., Wang, C., Covey, D. F., Eisenman, L. N., & Zorumski, C. F. (2008) · Biophysical Journal · doi:10.1529/biophysj.107.124768 · Cited by 17 · see citing works

Usefulness of plasma pregnenolone sulfate in testing pituitary-adrenal function in children

PERETTI, E. D., Forest, M., LORAS, B., Morel, Y., David, M., François, R., & Bertrand, J. (1986) · European Journal of Endocrinology · doi:10.1530/acta.0.112s259 · Cited by 15 · see citing works

Pregnenolone and Pregnenolone Sulfate Metabolismin Vivoand Uterine Extraction at Midgestation

Billiar, R. B., Jassani, M. N., Saarikoski, S., & Little, B. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-1-27 · Cited by 13 · see citing works

Neuroactive steroids, their precursors and polar conjugates during parturition and postpartum in maternal and umbilical blood: 3.3β-hydroxy-5-ene steroids

Hill, M., Pařı́zek, A., Klak, J., Hampl, R., Šulcová, J., Havlı́ková, H., Lapčı́k, O., Bičı́ková, M., Fait, T., Kancheva, R. L., et al. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00188-7 · Cited by 13 · see citing works

Measurement of Pregnenolone Sulfate After Solvolysis in Human Pregnancy Plasma

Scommegna, A., BIENIARZ, J., & Wineman, C. G. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-5-787 · Cited by 11 · see citing works

The effect of pregnenolone sulfate on uterine contractility

Scommegna, A., Burd, L. I., Goodman, C., & Bieniarz, J. (1970) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(70)90447-3 · Cited by 8 · see citing works

Effect of pregnenolone sulfate administration on the excretion of steroid hormones in pregnant women

Chattoraj, S. C., Pinkus, J. L., & Charles, D. (1970) · Steroids · doi:10.1016/s0039-128x(70)80134-9 · Cited by 6 · see citing works

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

Alexander, S. P. H., Mathie, A. A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14749 · Cited by 605 · see citing works

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

Wu, L., Sweet, T.-B., & Clapham, D. E. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002725 · Cited by 591 · see citing works

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

Vriens, J., Owsianik, G., Hofmann, T., Philipp, S. E., Stäb, J., Chen, X. F., Benoit, M., Xue, F., Janssens, A., Kerselaers, S., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.051 · Cited by 577 · see citing works

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

Nilius, B., & SZALLASI, A. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008268 · Cited by 504 · see citing works

Peripheral thermosensation in mammals

Vriens, J., Nilius, B., & Voets, T. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3784 · Cited by 453 · see citing works

Transient receptor potential ( TRP ) channels: a clinical perspective

Kaneko, Y., & SZALLASI, A. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12414 · Cited by 373 · see citing works

Regulation of Pain and Itch by TRP Channels

Moore, C. D., Gupta, R., Jordt, S., Chen, Y., & Liedtke, W. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0200-8 · Cited by 311 · see citing works

Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks

Akerman, İ., Tu, Z., Beucher, A., Rolando, D., Sauty-Colace, C., Benazra, M., Nakić, N., Yang, J., Wang, H., Pasquali, L., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.11.016 · Cited by 249 · see citing works

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Alexander, S. P. H., Mathie, A. A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15539 · Cited by 247 · see citing works

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

Alexander, S. P. H., Mathie, A. A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Davies, J. A., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16178 · Cited by 201 · see citing works

Mechanosensitive TRP channels in cardiovascular pathophysiology

Inoue, R., Zhong, J., & Kawarabayashi, Y. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.05.009 · Cited by 189 · see citing works

TRPM3 and miR-204 Establish a Regulatory Circuit that Controls Oncogenic Autophagy in Clear Cell Renal Cell Carcinoma

Hall, D., Cost, N. G., Hegde, S., Kellner, E., Mikhaylova, O., Stratton, Y., Ehmer, B., Abplanalp, W. A., Pandey, R., Biesiada, J., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.015 · Cited by 186 · see citing works

Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice

Uchida, K., Dezaki, K., Boldbaatar, D., Inada, H., Shiuchi, T., Mori, Y., Yada, T., Minokoshi, Y., & Tominaga, M. (2010) · Diabetes · doi:10.2337/db10-0276 · Cited by 182 · see citing works

The G Protein–Coupled Receptor–Transient Receptor Potential Channel Axis: Molecular Insights for Targeting Disorders of Sensation and Inflammation

Veldhuis, N. A., Poole, D. P., Grace, M. S., McIntyre, P., & Bunnett, N. W. (2014) · Pharmacological Reviews · doi:10.1124/pr.114.009555 · Cited by 172 · see citing works

Sensory TRP Channels

Mickle, A. D., Shepherd, A. J., & Mohapatra, D. P. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.01.002 · Cited by 168 · see citing works

TRP Channels

Gees, M., Owsianik, G., Nilius, B., & Voets, T. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110026 · Cited by 168 · see citing works

Bile Acids Acutely Stimulate Insulin Secretion of Mouse β-Cells via Farnesoid X Receptor Activation and KATP Channel Inhibition

Düfer, M., Hörth, K., Wagner, R., Schittenhelm, B., Prowald, S., Wagner, T. F. J., Oberwinkler, J., Łukowski, R., Gonzalez, F. J., Krippeit‐Drews, P., et al. (2012) · Diabetes · doi:10.2337/db11-0815 · Cited by 160 · see citing works

Electrophysiology of Islet Cells

Drews, G., Krippeit-Drews, P., & Düfer, M. (2010) · Advances in Experimental Medicine and Biology · doi:10.1007/978-90-481-3271-3_7 · Cited by 152 · see citing works

The TRPA1 channel in migraine mechanism and treatment

Benemei, S., Fusi, C., Trevisan, G., & Geppetti, P. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12512 · Cited by 146 · see citing works

Flavanones That Selectively Inhibit TRPM3 Attenuate Thermal Nociception In Vivo

Straub, I., Krügel, U., Mohr, F., Teichert, J., Rizun, O., Konrad, M., Oberwinkler, J., & Schaefer, M. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.086843 · Cited by 146 · see citing works

Natural and synthetic modulators of SK (Kca2) potassium channels inhibit magnesium‐dependent activity of the kinase‐coupled cation channel TRPM7

Chubanov, V., y Schnitzler, M. M., Meißner, M., Schäfer, S., Abstiens, K., Hofmann, T., & Gudermann, T. W. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01855.x · Cited by 142 · see citing works

Pregnenolone Sulphate- and Cholesterol-Regulated TRPM3 Channels Coupled to Vascular Smooth Muscle Secretion and Contraction

Naylor, J., Li, J., Milligan, C. J., Zeng, F., Sukumar, P., Hou, B., Sedó, A., Yuldasheva, N. Y., Majeed, Y., Beri, D., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.219329 · Cited by 142 · see citing works

The role of transient receptor potential channels in kidney disease

Woudenberg-Vrenken, T. E., Bindels, R. J. M., & Hoenderop, J. G. J. (2009) · Nature Reviews Nephrology · doi:10.1038/nrneph.2009.100 · Cited by 141 · see citing works

Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release

Held, K., Kichko, T. I., Clercq, K. D., Klaassen, H., Bree, R. V., Vanherck, J., Marchand, A., Reeh, P. W., Chaltin, P., Voets, T., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419845112 · Cited by 140 · see citing works

Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) and Its Role in Insulin Release from Rat Pancreatic Beta Cells

Cao, D.-S., Zhong, L., Hsieh, T.-H. J., Abooj, M., Bishnoi, M., Hughes, L. K., & Premkumar, L. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038005 · Cited by 134 · see citing works

Fenamates as TRP channel blockers: mefenamic acid selectively blocks TRPM3

Klose, C., Straub, I., Riehle, M., Ranta, F., Krautwurst, D., Ullrich, S., Meyerhof, W., & Harteneck, C. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01186.x · Cited by 131 · see citing works

Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies

Mickle, A. D., Shepherd, A. J., & Mohapatra, D. P. (2016) · Pharmaceuticals · doi:10.3390/ph9040072 · Cited by 130 · see citing works

The TRPM8 Protein Is a Testosterone Receptor

Asuthkar, S., Demirkhanyan, L. H., Sun, X., Elustondo, P. A., Krishnan, V., Baskaran, P., Velpula, K. K., Thyagarajan, B., Pavlov, E. V., & Zakharian, E. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.610873 · Cited by 127 · see citing works

TRPM1: The endpoint of the mGluR6 signal transduction cascade in retinal ON‐bipolar cells

Morgans, C. W., Brown, R. L., & Duvoisin, R. M. (2010) · BioEssays · doi:10.1002/bies.200900198 · Cited by 121 · see citing works

TRP channels and analgesia

Premkumar, L. S., & Abooj, M. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.08.010 · Cited by 113 · see citing works

Trafficking of ThermoTRP Channels

Ferrándiz‐Huertas, C., Mathivanan, S., Wolf, C. J., Devesa, I., & Ferrer-Montiel, A. V. (2014) · Membranes · doi:10.3390/membranes4030525 · Cited by 112 · see citing works

Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels

Dembla, S., Behrendt, M., Mohr, F., Goecke, C., Sondermann, J. R., Schneider, F., Schmidt, M., Stäb, J., Enzeroth, R., Leitner, M. G., et al. (2017) · eLife · doi:10.7554/elife.26280 · Cited by 112 · see citing works

Opening of an alternative ion permeation pathway in a nociceptor TRP channel

Vriens, J., Held, K., Janssens, A., Tóth, B. I., Kerselaers, S., Nilius, B., Vennekens, R., & Voets, T. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1428 · Cited by 111 · see citing works

Pax6 Regulates Gene Expression in the Vertebrate Lens through miR-204

Shaham, O., Gueta, K., Mor, E., Oren‐Giladi, P., Grinberg, D., Xie, Q. M., Cvekl, A., Shomron, N., Davis, N., Keydar-Prizant, M., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003357 · Cited by 107 · see citing works

Permeation, regulation and control of expression of TRP channels by trace metal ions

Bouron, A., Kiselyov, K. I., & Oberwinkler, J. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1590-3 · Cited by 106 · see citing works

The TRPM8 Protein Is a Testosterone Receptor

Asuthkar, S., Elustondo, P. A., Demirkhanyan, L. H., Sun, X., Baskaran, P., Velpula, K. K., Thyagarajan, B., Pavlov, E. V., & Zakharian, E. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.610824 · Cited by 104 · see citing works

SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia

Chen, K., Xie, L., Gunasekar, S. K., Mishra, A., Zhang, Y., Pai, S., Gao, Y., Kumar, A., Norris, A. W., Stephens, S. B., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02664-0 · Cited by 104 · see citing works

Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM 3

Straub, I., Mohr, F., Stäb, J., Konrad, M., Philipp, S. E., Oberwinkler, J., & Schaefer, M. (2012) · British Journal of Pharmacology · doi:10.1111/bph.12076 · Cited by 103 · see citing works

TRP Channel Cooperation for Nociception: Therapeutic Opportunities

Bamps, D., Vriens, J., Hoon, J. N. J. M. D., & Voets, T. (2020) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023238 · Cited by 102 · see citing works

Primidone inhibits TRPM3 and attenuates thermal nociception in vivo

Krügel, U., Straub, I., Beckmann, H., & Schaefer, M. (2017) · Pain · doi:10.1097/j.pain.0000000000000846 · Cited by 102 · see citing works

Steroids and insulin resistance in pregnancy

Vejražková, D., Včelák, J., Vaňková, M., Lukášová, P., Bradnová, O., Hálková, T., Kancheva, R. L., & Bendlová, B. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.11.007 · Cited by 101 · see citing works

TRPA1 and other TRP channels in migraine

Benemei, S., Cesaris, F. D., Fusi, C., Rossi, E., Lupi, C., & Geppetti, P. (2013) · The Journal of Headache and Pain · doi:10.1186/1129-2377-14-71 · Cited by 100 · see citing works

Transient receptor potential channels and vascular function

Earley, S., & Brayden, J. E. (2010) · Clinical Science · doi:10.1042/cs20090641 · Cited by 98 · see citing works

Evidence for the role of lipid rafts and sphingomyelin in Ca2+-gating of Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve terminals

Sághy, É., Szőke, É., Payrits, M., Helyes, Z., Börzsei, R., Erostyák, J., Jánosi, T. Z., Sétáló, G., & Szolcsányi, J. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.07.028 · Cited by 98 · see citing works

Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics

Valente, J. D. S., Andreou, A. P., Urbán, L., & Nagy, I. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12532 · Cited by 97 · see citing works

Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders

Ratner, M. H., Kumaresan, V., & Farb, D. H. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00169 · Cited by 96 · see citing works

ThermoTRPs and Pain

Laing, R. J., & Dhaka, A. (2015) · The Neuroscientist · doi:10.1177/1073858414567884 · Cited by 96 · see citing works

Activation of TRPM7 channels by small molecules under physiological conditions

Hofmann, T., Schäfer, S., Linseisen, M., Sytik, L., Gudermann, T. W., & Chubanov, V. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1488-0 · Cited by 95 · see citing works

Involvement of thermosensitive TRP channels in energy metabolism

Uchida, K., Dezaki, K., Yoneshiro, T., Watanabe, T., Yamazaki, J., Saito, M., Yada, T., Tominaga, M., & Iwasaki, Y. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-017-0552-x · Cited by 95 · see citing works

Molecular and cellular mechanisms that initiate pain and itch

Luo, J., Feng, J., Liu, S., Walters, E. T., & Hu, H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1904-4 · Cited by 93 · see citing works

G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons

Quallo, T., Alkhatib, O., Gentry, C., Andersson, D. A., & Bevan, S. (2017) · eLife · doi:10.7554/elife.26138 · Cited by 93 · see citing works

TRPM3 channels provide a regulated influx pathway for zinc in pancreatic beta cells

Wagner, T. F. J., Drews, A., Loch, S., Mohr, F., Philipp, S. E., Lambert, S., & Oberwinkler, J. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0838-9 · Cited by 92 · see citing works

Differential effects of lipopolysaccharide on mouse sensory TRP channels

Boonen, B., Alpizar, Y. A., Sánchez, A., López‐Requena, A., Voets, T., & Talavera, K. (2018) · Cell Calcium · doi:10.1016/j.ceca.2018.04.004 · Cited by 91 · see citing works

TRPM channels in health and disease

Chubanov, V., Köttgen, M., Touyz, R. M., & Gudermann, T. W. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00777-y · Cited by 91 · see citing works

Ionic mechanisms in pancreatic β cell signaling

Yang, S. N., Shi, Y., Yang, G., Li, Y., Yu, J. H., & Berggren, P. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1680-6 · Cited by 91 · see citing works

Pregnenolone sulfate: from steroid metabolite to TRP channel ligand

Harteneck, C. (2013) · Molecules · doi:10.3390/molecules181012012 · Cited by 89 · see citing works

TRPM Channels in Human Diseases

Jiménez-Dinamarca, I., Prado, Y., Marchant, F., Otero, C., Eltit, F., Cabello‐Verrugio, C., Cerda, O., & Simón, F. (2020) · Cells · doi:10.3390/cells9122604 · Cited by 89 · see citing works

Neuroactive Steroids: Receptor Interactions and Responses

Tuem, K. B., & Atey, T. M. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00442 · Cited by 89 · see citing works

The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain

Hossain, M. Z., Bakri, M. M., Yahya, F., Ando, H., Unno, S., & Kitagawa, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030526 · Cited by 88 · see citing works

TRPM3

Oberwinkler, J., & Philipp, S. E. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-54215-2_17 · Cited by 88 · see citing works

Transient Receptor Potential Melastatin 1 (TRPM1) Is an Ion-conducting Plasma Membrane Channel Inhibited by Zinc Ions

Lambert, S., Drews, A., Rizun, O., Wagner, T. F. J., Lis, A., Mannebach, S., Plant, S., Portz, M., Meissner, M., Philipp, S. E., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202945 · Cited by 85 · see citing works

Transient receptor potential TRPM3 channels: Pharmacology, signaling, and biological functions

Thiel, G., Rubil, S., Lesch, A., Guethlein, L. A., & Rößler, O. G. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.07.014 · Cited by 83 · see citing works

TRP Channels of Islets

Islam, M. S. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-0265-3_42 · Cited by 79 · see citing works

Lipids as central modulators of sensory TRP channels

Ciardo, M. G., & Ferrer-Montiel, A. V. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.04.012 · Cited by 78 · see citing works

Targeting TRP channels for pain relief: A review of current evidence from bench to bedside

Koivisto, A., Voets, T., Iadarola, M. J., & SZALLASI, A. (2024) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2024.102447 · Cited by 76 · see citing works

TRPM3 is expressed in sphingosine‐responsive myelinating oligodendrocytes

Hoffmann, A., Grimm, C. M., Kraft, R., Goldbaum, O., Wrede, A., Nolte, C., Hanisch, U., Richter‐Landsberg, C., Brück, W., Kettenmann, H., et al. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06644.x · Cited by 76 · see citing works

The role of thermosensitive TRP (transient receptor potential) channels in insulin secretion [Review]

Uchida, K., & Tominaga, M. (2011) · Endocrine Journal · doi:10.1507/endocrj.ej11-0130 · Cited by 76 · see citing works

Alternative Splicing of a Protein Domain Indispensable for Function of Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channels

Frühwald, J., Londoño, J. C., Dembla, S., Mannebach, S., Lis, A., Drews, A., Wissenbach, U., Oberwinkler, J., & Philipp, S. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.396663 · Cited by 75 · see citing works

Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone

Majeed, Y., Tumova, S., Green, B. L., Seymour, V. A. L., Woods, D., Agarwal, A. K., Naylor, J., Jiang, S., Picton, H. M., Porter, K. E., et al. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.09.005 · Cited by 75 · see citing works

TRPM3 in temperature sensing and beyond

Held, K., Voets, T., & Vriens, J. (2015) · Temperature · doi:10.4161/23328940.2014.988524 · Cited by 75 · see citing works

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

Alexander, S. P. H., Striessnig, J., Gibb, A. J., Mathie, A. A., Veale, E. L., Kelly, E., Peach, C. J., Armstrong, J. F., Faccenda, E., Harding, S. D., et al. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70231 · Cited by 73 · see citing works

The Role of TRP Proteins in Mast Cells

Freichel, M., Almering, J., & Tsvilovskyy, V. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00150 · Cited by 73 · see citing works

Signal Transduction of Pregnenolone Sulfate in Insulinoma Cells

Mayer, S. I., Müller, I., Mannebach, S., Endo, T., & Thiel, G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202697 · Cited by 72 · see citing works

Rationalizing Steroid Interactions with Lipid Membranes: Conformations, Partitioning, and Kinetics

Atkovska, K., Klingler, J., Oberwinkler, J., Keller, S., & Hub, J. S. (2018) · ACS Central Science · doi:10.1021/acscentsci.8b00332 · Cited by 71 · see citing works

Rapid and Contrasting Effects of Rosiglitazone on Transient Receptor Potential TRPM3 and TRPC5 Channels

Majeed, Y., Naguib, Y. M., Seymour, V. A. L., Wilson, L. A., Milligan, C. J., Agarwal, A. K., Sukumar, P., Naylor, J., & Beech, D. J. (2011) · Molecular Pharmacology · doi:10.1124/mol.110.069922 · Cited by 70 · see citing works

TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity

Kusudo, T., Wang, Z., Mizuno, A., Suzuki, M., & Yamashita, H. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01070.2011 · Cited by 70 · see citing works

Structural and functional analyses of a GPCR-inhibited ion channel TRPM3

Zhao, C., & MacKinnon, R. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.002 · Cited by 69 · see citing works

Zinc-Permeable Ion Channels: Effects on Intracellular Zinc Dynamics and Potential Physiological/Pathophysiological Significance

Inoue, K., O’Bryant, Z., & Xiong, Z. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867322666150209153750 · Cited by 69 · see citing works

Regulation of the transient receptor potential channel TRPM3 by phosphoinositides

Tóth, B. I., Konrad, M., Ghosh, D., Mohr, F., Halaszovich, C. R., Leitner, M. G., Vriens, J., Oberwinkler, J., & Voets, T. (2015) · The Journal of General Physiology · doi:10.1085/jgp.201411339 · Cited by 69 · see citing works

TRP Channels and Pain

González-Ramírez, R., Chen, Y., Liedtke, W. B., & Morales-Lázaro, S. L. (2017) · Frontiers in neuroscience · doi:10.1201/9781315152837-9 · Cited by 69 · see citing works

Activation of steroid‐sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats

Zamudio, P. A., Everett, J. C., Harteneck, C., & Valenzuela, C. F. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07441.x · Cited by 67 · see citing works

Transient receptor potential melastatin 3 is a phosphoinositide-dependent ion channel

Badheka, D., Borbíró, I., & Rohács, T. (2015) · The Journal of General Physiology · doi:10.1085/jgp.201411336 · Cited by 66 · see citing works

Transient Receptor Potential Cation Channels in Pancreatic β Cells

Colsoul, B., Vennekens, R., & Nilius, B. (2011) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2011_2 · Cited by 65 · see citing works

TRPM3 Channels Play Roles in Heat Hypersensitivity and Spontaneous Pain after Nerve Injury

Su, S., Yudin, Y. K., Kim, N., Tao, Y., & Rohács, T. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1551-20.2020 · Cited by 64 · see citing works

Estrogen destabilizes microtubules through an ion‐conductivity‐independent TRPV1 pathway

Goswami, C., Kuhn, J., Dina, O. A., Fernandez-Ballester, G. J., Levine, J. D., Ferrer-Montiel, A. V., & Hucho, T. B. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07270.x · Cited by 64 · see citing works

TRP Channels in Digestive Tract Cancers

Stokłosa, P., Borgström, A., Kappel, S., & Peinelt, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051877 · Cited by 64 · see citing works

The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes

Hariharan, A., Weir, N., Robertson, C., He, L., Betsholtz, C., & Longden, T. A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.601324 · Cited by 63 · see citing works

TRP Modulation by Natural Compounds

Meotti, F. C., de Andrade, E. L., & Calixto, J. Β. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-05161-1_19 · Cited by 63 · see citing works

Calcium Signaling in the Islets

Islam, M. S. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-90-481-3271-3_11 · Cited by 63 · see citing works

The emerging role of transient receptor potential channels in chronic lung disease

Belvisi, M. G., & Birrell, M. A. (2017) · European Respiratory Journal · doi:10.1183/13993003.01357-2016 · Cited by 63 · see citing works

Cis‐isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels

Majeed, Y., Agarwal, A., Naylor, J., Seymour, V., Jiang, S., Muraki, K., Fishwick, C. W. G., & Beech, D. J. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00892.x · Cited by 63 · see citing works

Sympathetic and sensory-motor nerves in peripheral small arteries

Aalkjær, C., Nilsson, H., & Mey, J. G. R. D. (2020) · Physiological Reviews · doi:10.1152/physrev.00007.2020 · Cited by 62 · see citing works

Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122

Leitner, M. G., Michel, N., Behrendt, M., Dierich, M., Dembla, S., Wilke, B. U., Konrad, M., Lindner, M., Oberwinkler, J., & Oliver, D. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13538 · Cited by 62 · see citing works

Vanilloid and Melastatin Transient Receptor Potential Channels in Vascular Smooth Muscle

Earley, S. (2010) · Microcirculation · doi:10.1111/j.1549-8719.2010.00026.x · Cited by 60 · see citing works

Integration of transient receptor potential canonical channels with lipids

Beech, D. J. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02311.x · Cited by 59 · see citing works

Pregnenolone sulfate as a modulator of synaptic plasticity

Smith, C. C., Gibbs, T. T., & Farb, D. H. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3643-x · Cited by 58 · see citing works

Structural requirements of steroidal agonists of transient receptor potential melastatin 3 ( TRPM 3) cation channels

Drews, A., Mohr, F., Rizun, O., Wagner, T. F. J., Dembla, S., Rudolph, S., Lambert, S., Konrad, M., Philipp, S. E., Behrendt, M., et al. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12521 · Cited by 58 · see citing works

Influence of membrane cholesterol in the molecular evolution and functional regulation of TRPV4

Kumari, S., Kumar, A., Sardar, P., Yadav, M., Majhi, R. K., Kumar, A., & Goswami, C. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.11.077 · Cited by 57 · see citing works

Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy

Hoeymissen, E. V., Held, K., Freitas, A. C. N., Janssens, A., Voets, T., & Vriens, J. (2020) · eLife · doi:10.7554/elife.57190 · Cited by 57 · see citing works

Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice

Zhou, Q., Fu, X., Xu, J., Dong, S., Liu, C., Cheng, D., Gao, C., Huang, M., Liu, Z., Ni, X., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.11.008 · Cited by 56 · see citing works

Signal transduction via TRPM3 channels in pancreatic β-cells

Thiel, G., Müller, I., & Rößler, O. G. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0237 · Cited by 51 · see citing works

D-erythro-Sphingosine and Pregnenolonesulphate activate TRPM3 channels synergistically in INS- 1E cells

Halim, M. A. (2017) · Bangladesh Journal of Medical Science · doi:10.3329/bjms.v16i1.31140

Control of Insulin Release by Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channels

Becker, A., Mannebach, S., Mathar, I., Weißgerber, P., Freichel, M., Loodin, A. P., Fecher‐Trost, C., Belkacemi, A., Beck, A., & Philipp, S. E. (2020) · Cellular Physiology and Biochemistry · doi:10.33594/000000304 · Cited by 22 · see citing works

Turning On TRPM3

Adler, E. M. (2008) · Science Signaling · doi:10.1126/scisignal.149ec419

Transient receptor potential TRPM3 channels: Pharmacology, signaling, and biological functions

Thiel, G., Rubil, S., Lesch, A., Guethlein, L. A., & Rößler, O. G. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.07.014 · Cited by 83 · see citing works