p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence

Fujita, Kaori, Mondal, Abdul M., Horikawa, Izumi, Nguyen, Giang H., Kumamoto, Kensuke, Sohn, Jane J., Bowman, Elise D., Mathe, Ewy A. +7 more·2009·Nature Cell Biology
DOI 10.1038/ncb1928

Cited by (336)

Items 301–336 of 336

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    Van Hook, Kathryn Dianne · 2013
  2. Δ133p53 Functions to Maintain Redox Homeostasis in Response to Low ROS Stresses
    Jiang Jun Chen · 2016 · Single Cell Biology
  3. Discovery and characterization of a novel splice variant of the p53 tumor suppressor gene in a human T cell leukemia cellline.
    Xiaomei Li, Yingshou Lei, Yang Y. Yu, Yaqian Zhang, Wenfeng Zhang, Han Shen, Changli Tao, Fenglin Wu, Shulin Huang, Hongwei Shao · 2020 · PubMed Central
  4. Porcine model elucidates function of p53 isoform in carcinogenesis
    Guanglin Niu, Isabel Hellmuth, Tatiana Flisikowska, Hubert Pausch, Beate Rieblinger, Alexander Rinke Carrapeiro, Benjamin Schade, Brigitte Böhm, Eva Kappe, Konrad Fischer et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  5. A microRNA Cluster-Lefty Pathway is Required for Cellulose Synthesis During Ascidian Larval Metamorphosis
    Xueping Sun, Xiaoming Zhang, Likun Yang, Bo Dong · 2022 · Frontiers in Cell and Developmental Biology
  6. POLR3A-mutated Wiedemann-Rautenstrauch fibroblasts display differential profile of intron retention and expression of TP53 isoforms
    Paula V. Gaete, Daniel F. Santos-Gil, Humberto Arboleda, Gonzálo Arboleda · 2024 · Translational Science of Rare Diseases
  7. Genetic Predisposition
    Apexa Modi, Emily R. Blauel, Sharon J. Diskin · 2024 · Pediatric oncology
  8. p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners
    Anamari Brdar, Christian Osterburg, Philipp Münick, Anne Christin Machel, Rajeshwari Rathore, Susanne Osterburg, Büşra Yüksel, Birgit Schäfer, Kristina Desch, Julian D. Langer et al. · 2025 · eLife
  9. Analysis of G:C>T:A, G:C>A:T, and G:C>C:G Mutations in the TP53 Gene in Women with and without Breast Cancer in the Long-Term Period after Chronic Radiation Exposure
    Никифоров Владислав Сергеевич, А. V. Korechenkova, А. V. Akleyev · 2024 · Biology Bulletin
  10. p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners
    Anamari Brdar, Christian Osterburg, Philipp Münick, Anne Christin Machel, Rajeshwari Rathore, Susanne Osterburg, Büşra Yüksel, Birgit Schäfer, Kristina Desch, Julian D. Langer et al. · 2024 · eLife
  11. Analysis of G:C>T:A, G:C>A:T and G:C>C:G mutations in the TP53 gene in women with and without breast cancer in the long term period after chronic radiation exposure
    Никифоров Владислав Сергеевич, А. V. Korechenkova, А. V. Akleyev · 2024 · Известия Российской академии наук Серия биологическая
  12. Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation
    Liuqun Zhao, Tanel Punga, Suparna Sanyal · 2025 · eLife
  13. p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners
    Anamari Brdar, Christian Osterburg, Philipp Münick, Anne Christin Machel, Rajeshwari Rathore, Susanne Osterburg, Büşra Yüksel, Birgit Schäfer, Kristina Desch, Julian D. Langer et al. · 2025 · eLife
  14. Pharmacologic activation of Δ133p53α reduces cellular senescence in progeria patients-derived cells
    Sebastien M. Joruiz, Delphine Lissa, Natalia von Muhlinen, Patricia K. Dranchak, James Inglese, Izumi Horikawa, Curtis C. Harris · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Additional file 1 of EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cells
    Miyanaga, Akihiko, Matsumoto, Masaru, Beck, Jessica A., Izumi Horikawa, Oike, Takahiro, Okayama, Hirokazu, Hiromi Tanaka, Burkett, Sandra S., Robles, Ana I., Khan, Mohammed et al. · 2021 · Figshare
  16. Senescence-inhibitory Δ133p53α counteracts accelerated ageing and mortality
    Leo Yamada, Huaitian Liu, Natalia von Muhlinen, Curtis C. Harris, Izumi Horikawa · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  17. New Δ246p53 Isoform Responds to DNA Damage to Enhance P53 Family Functions in Senescence and Tumour Suppression
    Marco M. Candeias, Shrutee N. Parkar, Ana Catarina Ramalho, Maria José López-Iniesta, Jingyuan Zhao, Koto Kimura, Filipa da Silva Rita, Luı́sa Romão · 2025 · SSRN Electronic Journal
  18. Structural potential of the 5′ noncoding regions of the mRNAs encoding p53 isoforms
    Mariola Dutkiewicz, Paulina Żydowicz-Machtel · 2026 · Acta Biochimica Polonica
  19. N-terminal isoforms of the p53 tumour suppressor protein : effects on p53 transcriptional activity and expression in cutaneous melanoma
    Hind Hafsi · 2012
  20. The role of NEDD8 pathway in cell invasion and strategies for the use of NEDD8 inhibitors in the clinic
    Lara J. Bou Malhab · 2016 · theses.fr (ABES)
  21. Host-pathogens interactions during RSV / S. pneumoniae infection immune response and p53 pathway
    Daniela Bandeira Brancante Machado · 2017 · theses.fr (ABES)
  22. Characterization of the Signaling Pathways Involved in Cellular Cannibalism Elicited by Ionizing Radiation
    Dorine de Jong · 2018 · theses.fr (ABES)
  23. Étude de l'infection par le métapneumovirus humain : facteurs de virulence et développement de vaccins vivants atténués
    Julia Dubois · 2018
  24. The role of the transcription factor BRN2 in melanomagenesis
    Michael HAMM · 2018
  25. The regulation of the p53 isoform p47 following Endoplasmic Reticulum (ER) stress, and physiological implication of single cancer-derived synonymous mutations in initiation of p53 mRNA translation
    Leïla T. S. Fusée · 2020 · theses.fr (ABES)
  26. Generation of antisense RNAs at convergent gene loci in cells undergoing senescence
    Maharshi Krishna Deb · 2016 · theses.fr (ABES)
  27. Développement d'un biosenseur fluorescent d'un mutant de p53 sujet à l'agrégation dans les cancers
    Morgan Pellerano · 2019
  28. The role of p53 during chikungunya virus infection in mammal and insect
    Lucie Cappuccio · 2020 · theses.fr (ABES)
  29. Rôles et régulation des isoformes protéiques d'HBZ du HTLV-1 & de Fra-2 dans la Leucémie T de l'Adulte
    Julie Tram · 2022 · theses.fr (ABES)
  30. The p53 Isoforms as Potential Biomarkers in Different Cancer Entities
    christine supina pavic, Anđela Horvat, Ana Tadijan, Janja Josić, Martina Deželjin, Maja Jazvinšćak Jembrek, Ignacija Vlašić, Neda Slade · 2026 · International Journal of Molecular Sciences
  31. TP53 isoform dysregulation in pediatric B-ALL: identifying markers of favorable prognosis and relapse-associated dynamic
    P. Kaur, T. K. Hasib, Sargeet Kaur, Sharun, P. Bhatia, Amita Trehan, M. Sachdeva, S. Sreedharanunni, Minu Singh · 2026 · Molecular Biology Reports
  32. The Dynamic Alliance of p53 and Metabolism in the Tumor Microenvironment Shapes Tumor Evolution
    Sebastien M. Joruiz, Francesco Napoletano, Rebecca Bertolio, Giannino Del Sal · 2026 · BioEssays
  33. Adenosine Deaminase-Mediated Purine Dysfunction Leads to DNA Repair Inhibition and Senescence in Sporadic Amyotrophic Lateral Sclerosis
    Benjamin Hall, Yasmina M. Ebrahim, Joanne L. Sharpe, Sangeet Makhija, Brittany C. S. Ellis, Kari E. Wong, Heather J. Walker, Miriam Yagüe-Capilla, Hannah O. Timmons, Arian Bradley et al. · 2026 · International Journal of Molecular Sciences
  34. Germline TP53 noncoding variant (rs78378222) prevalence in cohorts of prostatic adenocarcinoma and benign prostatic hyperplasia: further evidence from southern Brazil and novel insights into its functional impact mediated by the circRNAs-miRNAs-TP53 regulatory axis
    Igor Araújo Vieira, Guilherme Danielski Viola, Eduarda Heidrich Pezzi, Thayne Woycinck Kowalski, Bruna Fernandes, Natascha Bom, Giulianna Sonnenstrahl, B.R. da Silva, Monique Banik Siqueira, Renan Mascarello Silva et al. · 2026 · Research Square
  35. Alternative Isoforms as Molecular Modulators of Cellular Senescence in Cancer
    José Manuel García-Heredia · 2026 · Cancers
  36. Role of p53 and its isoforms in the expression of FGF-2 and tumoral neovascularization
    H. Bernard · 2010 · Discovery Research Portal (University of Dundee)