The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells
Open accessAbstract
Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and catalyses the trimethylation of histone H3 on Lys 27 (H3K27), which represses gene transcription. EZH2 enhances cancer-cell invasiveness and regulates stem cell differentiation. Here, we demonstrate that EZH2 can be phosphorylated at Thr 487 through activation of cyclin-dependent kinase 1 (CDK1). The phosphorylation of EZH2 at Thr 487 disrupted EZH2 binding with the other PRC2 components SUZ12 and EED, and thereby inhibited EZH2 methyltransferase activity, resulting in inhibition of cancer-cell invasion. In human mesenchymal stem cells, activation of CDK1 promoted mesenchymal stem cell differentiation into osteoblasts through phosphorylation of EZH2 at Thr 487. These findings define a signalling link between CDK1 and EZH2 that may have an important role in diverse biological processes, including cancer-cell invasion and osteogenic differentiation of mesenchymal stem cells.
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Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., & Zhang, Y. (2002) · Science · doi:10.1126/science.1076997 · Cited by 3,775
The polycomb group protein EZH2 is involved in progression of prostate cancer
Varambally, S., Dhanasekaran, S. M., Zhou, M., Barrette, T. R., Kumar-Sinha, C., Sanda, M. G., Ghosh, D., Pienta, K. J., Sewalt, R. G. A. B., Otte, A. P., et al. (2002) · Nature · doi:10.1038/nature01075 · Cited by 2,717
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EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
Bracken, A. P., Pasini, D., Capra, M., Prosperini, E., Colli, E., & Helin, K. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg542 · Cited by 1,196
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Regulation and Role of EZH2 in Cancer
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Self-citationEZH2 and KDM6A Act as an Epigenetic Switch to Regulate Mesenchymal Stem Cell Lineage Specification
Hemming, S., Cakouros, D., Isenmann, S., Cooper, L., Menicanin, D., Zannettino, A., & Gronthos, S. (2014) · Stem Cells · doi:10.1002/stem.1573 · Cited by 259
Prospective Review of Mesenchymal Stem Cells Differentiation into Osteoblasts
Garg, P., Mazur, M. M., Buck, A. C., Wandtke, M. E., Liu, J., & Ebraheim, N. A. (2017) · Orthopaedic Surgery · doi:10.1111/os.12304 · Cited by 190
STAT3/HOTAIR Signaling Axis Regulates HNSCC Growth in an EZH2-dependent Manner
Sun, S., Wu, Y., Guo, W., Yu, F., Kong, L., Ren, Y., Wang, Y., Yao, X., Jing, C., Zhang, C., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2248 · Cited by 93
Self-citationUbiquitin-specific protease 22 is a deubiquitinase of CCNB1
Lin, Z., Tan, C., Qiu, Q., Kong, S., Yang, H., Zhao, F., Liu, Z., Li, J., Kong, Q., Gao, B., et al. (2015) · Cell Discovery · doi:10.1038/celldisc.2015.28 · Cited by 90
Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement
Dai, Y.-J., Wang, Y.-Y., Huang, J.-Y., Xia, L., Shi, X.-D., Xu, J., Lu, J., Su, X.-B., Yang, Y., Zhang, W.-N., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703476114 · Cited by 78
Adamik, J., Jin, S., Sun, Q., Zhang, P., Weiss, K. R., Anderson, J. L., Silbermann, R., Roodman, G. D., & Galson, D. L. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0242-t · Cited by 73
Metadata
- Authors
- Wei, Y., Chen, Y.-H., Li, L.-Y., Lang, J., Yeh, S.-P., Shi, B., Yang, C.-C., Yang, J.-Y., Lin, C.-Y., Lai, C.-C., & Hung, M.-C.
- Venue
- Nature Cell Biology
- Published
- 2010-12-05
- Volume
- 13
- Issue
- 1
- Pages
- 87-94
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2140146894
- Cited by
- 384
- References
- 6
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- green
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